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Frequency-Dependent Noradrenergic Modulation of Long-Term Potentiation in the Hippocampus
Abstract
Norepinephrine, briefly superfused during high-frequency stimulation of the mossy fibers in the rat hippocampal slice in vitro, produced a reversible increase in the magnitude, duration, and probability of induction of long-term synaptic potentiation in the CA3 subfield. Similar results were obtained with isoproterenol, whereas propranolol or timolol reversibly blocked long-term potentiation. Norepinephrine had little apparent effect on responses obtained during low-frequency stimulation of the mossy fibers. These data suggest that norepinephrine can mediate long-lasting, frequency-dependent modulation of synaptic transmission in the mammalian brain. Furthermore, the results suggest a plausible mechanism for some of the known associative interactions between synaptic inputs to hippocampal neurons.
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Cites
Noradrenergic innervation of the adult rat hippocampal formation
Loy, R., Koziell, D. A., Lindsey, J. D., & Moore, R. Y. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901890406 · Cited by 443
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Stress effects on memory: An update and integration
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Metadata
- Authors
- Hopkins, W. F., & Johnston, D.
- Venue
- Science
- Published
- 1984-10-19
- Volume
- 226
- Issue
- 4672
- Pages
- 350-352
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976669574
- Cited by
- 256
- References
- 1
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
