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Transmission of HTLV-III Infection from Human Plasma to Chimpanzees: An Animal Model for AIDS
Abstract
Two of three chimpanzees given plasma from patients with acquired immune deficiency syndrome (AIDS) or pre-AIDS showed serum antibodies to type III human T-cell leukemia virus (HTLV-III) 10 to 12 weeks after transfusion. One animal also developed lymphadenopathy, transient depression of the ratio of T4 to T8 lymphocytes, and impaired blastogenic responses. No opportunistic infections occurred. Adenopathy persisted for 32 weeks, and antibody to HTLV-III persisted for at least 48 weeks. This transmission of HTLV-III by lymphocyte-poor plasma confirms the potential risk of such plasma or plasma derivatives to recipients. The susceptibility of the chimpanzee to HTLV-III infection and the ability to simulate the human lymphadenopathy syndrome in this animal makes it a valuable model for further study of AIDS.
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Cited by
Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III
Letvin, N. L., Daniel, M. D., Sehgal, P. K., Desrosiers, R. C., Hunt, R. D., Waldron, L. M., MacKey, J. J., Schmidt, D. K., Chalifoux, L. V., & King, N. W. (1985) · Science · doi:10.1126/science.2412295 · Cited by 616
Primary Human T-Lymphotropic Virus Type III Infection
HO, D. D., SARNGADHARAN, M. G., RESNICK, L., DIMARZOVERONESE, F., ROTA, T. R., & HIRSCH, M. S. (1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-6-880 · Cited by 334
Loss of Siglec expression on T lymphocytes during human evolution
Nguyen, D. H., Hurtado-Ziola, N., Gagneux, P., & Varki, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510484103 · Cited by 204
Metadata
- Authors
- Alter, H. J., Eichberg, J. W., Masur, H., Saxinger, W. C., Gallo, R., Macher, A. M., Lane, H. C., & Fauci, A. S.
- Venue
- Science
- Published
- 1984-11-02
- Volume
- 226
- Issue
- 4674
- Pages
- 549-552
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059770652
- Cited by
- 319
- References
- 0
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Transmission of HTLV-III Infection from Human Plasma to Chimpanzees: An Animal Model for AIDS. https://app.cochat.ai/papers/10.1126/science.6093251
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- Alter, H. J., Eichberg, J. W., Masur, H., Saxinger, W. C., Gallo, R., Macher, A. M., Lane, H. C., & Fauci, A. S. (1984). Transmission of HTLV-III Infection from Human Plasma to Chimpanzees: An Animal Model for AIDS. Science. https://doi.org/10.1126/science.6093251
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
