The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III
Abstract
The T-cell tropic retrovirus of macaque monkeys STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4 + peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.
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Cites
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Isolation of T-Cell Tropic HTLV-III-Like Retrovirus from Macaques
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Self-citationHTLV-III Infection in Brains of Children and Adults with AIDS Encephalopathy
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Cited by
Stevenson, M. (2003) · Nature Medicine · doi:10.1038/nm0703-853 · Cited by 441
Feline immunodeficiency virus infection
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Vaccine protection against simian immunodeficiency virus infection.
Desrosiers, R. C., Wyand, M. S., Kodama, T., Ringler, D. J., Arthur, L. O., Sehgal, P. K., Letvin, N. L., King, N. W., & Daniel, M. D. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6353 · Cited by 313
Self-citationImportance of vpr for infection of rhesus monkeys with simian immunodeficiency virus
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Metadata
- Authors
- Letvin, N. L., Daniel, M. D., Sehgal, P. K., Desrosiers, R. C., Hunt, R. D., Waldron, L. M., MacKey, J. J., Schmidt, D. K., Chalifoux, L. V., & King, N. W.
- Venue
- Science
- Published
- 1985-10-04
- Volume
- 230
- Issue
- 4721
- Pages
- 71-73
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080312964
- Cited by
- 616
- References
- 10
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III. https://app.cochat.ai/papers/10.1126/science.2412295
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- Letvin, N. L., Daniel, M. D., Sehgal, P. K., Desrosiers, R. C., Hunt, R. D., Waldron, L. M., MacKey, J. J., Schmidt, D. K., Chalifoux, L. V., & King, N. W. (1985). Induction of AIDS-Like Disease in Macaque Monkeys with T-Cell Tropic Retrovirus STLV-III. Science. https://doi.org/10.1126/science.2412295
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
