The DOI matches its Crossref record.
Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain
Abstract
In rats ischemia of the forebrain induced by a 30-minute occlusion of the carotid artery, followed by 120 minutes of arterial reperfusion, produced ischemic lesions of selectively vulnerable pyramidal cells in both hippocampi. Focal microinfusion into the dorsal hippocampus of 2-amino-7-phosphonoheptanoic acid, an antagonist of excitation at the N -methyl-D-aspartate-preferring receptor, before ischemia was induced protected against the development of ischemic damage. It is proposed that excitatory neurotransmission plays an important role in selective neuronal loss due to cerebral ischemia.
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Citations
Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Heteromeric NMDA receptors: molecular and functional distinction of subtypes
Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., & Seeburg, P. H. (1992) · Science · doi:10.1126/science.256.5060.1217 · Cited by 2,541
Tator, C. H., & Fehlings, M. G. (1991) · Journal of Neurosurgery · doi:10.3171/jns.1991.75.1.0015 · Cited by 1,577
Kynurenines in the mammalian brain: when physiology meets pathology
Schwarcz, R., Bruno, J. P., Muchowski, P. J., & Wu, H.-Q. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3257 · Cited by 1,530
Metadata
- Authors
- Simon, R. P., Swan, J. H., Griffiths, T., & Meldrum, B. S.
- Venue
- Science
- Published
- 1984-11-16
- Volume
- 226
- Issue
- 4676
- Pages
- 850-852
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2066168019
- Cited by
- 1,682
- References
- 0
- FWCI
- 19.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Simon, R. P., Swan, J. H., Griffiths, T., & Meldrum, B. S. (1984). Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain. Science. https://doi.org/10.1126/science.6093256
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
