The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons
Abstract
Prolonged treatment with classical antipsychotic drugs decreased the number of spontaneously active dopamine neurons in both the substantia nigra (A9) and the ventral tegmental area (A10) of the rat brain. In contrast, treatment with atypical antipsychotic drugs selectively decreased the number of A10 dopamine neurons. Related drugs lacking antipsychotic efficacy failed to decrease dopamine activity. These findings suggest that the inability of atypical antipsychotic drugs to decrease A9 dopamine neuronal activity may be related to their lower potential for causing tardive dyskinesia and that the inactivation of A10 neurons may be involved in the delayed onset of therapeutic effects during treatment.
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Citations
Cites
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220
Antipsychotic drug doses and neuroleptic/dopamine receptors
SEEMAN, P., LEE, T., CHAU-WONG, M., & WONG, K. (1976) · Nature · doi:10.1038/261717a0 · Cited by 1,622
Cited by
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831
On the significance of subterritories in the “accumbens” part of the rat ventral striatum
Zahm, D. S., & Brog, J. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90202-d · Cited by 1,040
Miyamoto, S., Duncan, G. E., Marx, C. E., & Lieberman, J. A. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001556 · Cited by 988
Gerfen, C., Herkenham, M., & Thibault, J. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-12-03915.1987 · Cited by 803
O'Donnell, P., & Grace, A. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03622.1995 · Cited by 760
Metadata
- Authors
- White, F. J., & Wang, R. Y.
- Venue
- Science
- Published
- 1983-09-09
- Volume
- 221
- Issue
- 4615
- Pages
- 1054-1057
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049074524
- Cited by
- 588
- References
- 2
- FWCI
- 23.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- White, F. J., & Wang, R. Y. (1983). Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons. Science. https://doi.org/10.1126/science.6136093
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
