Cited by 2,220Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and Signaling

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

Creese, Ian, Burt, David R., Snyder, Solomon H.·1976·Science

Abstract

Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.

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Crossref · 10.1126/science.3854

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25 of 25 references verified0 citation errors · 0 not checkable

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Authors
Creese, I., Burt, D. R., & Snyder, S. H.
Affiliations
Johns Hopkins University (US)
Venue
Science
Published
1976-04-30
Volume
192
Issue
4238
Pages
481-483
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2009447429
Cited by
2,220
References
25
Citations by year
2026: 11 · 2025: 24 · 2024: 30 · 2023: 24 · 2022: 39 · 2021: 27 · 2020: 32 · 2019: 39 · 2018: 25 · 2017: 36 · 2016: 43 · 2015: 53 · 2014: 44 · 2013: 47 · 2012: 55
FWCI
88.70
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
dopamine receptors, receptor binding, antipsychotic drugs, haloperidol, butyrophenones, phenothiazines, drug potency, postsynaptic dopamine receptors, drug evaluation
MeSH terms
Adenylyl Cyclases, Animals, Binding, Competitive, Butyrophenones, Corpus Striatum, Dopamine, Haloperidol, Humans, Olfactory Bulb, Phenothiazines, Receptors, Drug, Schizophrenia, Structure-Activity Relationship, Antipsychotic Agents, Dopamine Antagonists

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