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HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression
Abstract
A new human erythroleukemia cell line has been established. This line, designated HEL, is capable of spontaneous and induced globin synthesis, producing mainly Gγ and Aγ chains. Embryonic chains (ε, ζ) and α chains are detectable in very small amounts; β chains are undetectable. This line provides a new model system for studying aspects of erythroid cell differentiation and differential globin gene expression.
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Citations
Cited by
Thrombopoietin: the primary regulator of platelet production [see comments]
Kaushansky, K. (1995) · Blood · doi:10.1182/blood.v86.2.419.bloodjournal862419 · Cited by 642
The "beta-like-globin" gene domain in human erythroid cells.
Tuan, D., Solomon, W., Li, Q., & London, I. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.19.6384 · Cited by 601
Huang, M. M., Bolen, J. B., Barnwell, J. W., Shattil, S. J., & Brugge, J. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7844 · Cited by 406
Dettmer, U., Newman, A. J., Luth, E. S., Bartels, T., & Selkoe, D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.403311 · Cited by 221
Genomic subtyping and therapeutic targeting of acute erythroleukemia
Iacobucci, I., Wen, J., Meggendorfer, M., Choi, J. K., Shi, L., Pounds, S. B., Carmichael, C. L., Masih, K. E., Morris, S. M., Lindsley, R. C., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0375-1 · Cited by 155
Metadata
- Authors
- Martin, P., & Papayannopoulou, T.
- Venue
- Science
- Published
- 1982-06-11
- Volume
- 216
- Issue
- 4551
- Pages
- 1233-1235
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980878206
- Cited by
- 617
- References
- 0
- FWCI
- 15.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression. https://app.cochat.ai/papers/10.1126/science.6177045
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- Martin, P., & Papayannopoulou, T. (1982). HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression. Science. https://doi.org/10.1126/science.6177045
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
