The "beta-like-globin" gene domain in human erythroid cells.
Open accessAbstract
We have mapped the distribution of the major and minor DNase I-hypersensitive sites in the human "beta-like-globin" gene domain. The minor DNase I-hypersensitive sites map close to the 5' end of each of the beta-like-globin genes. Their presence is specifically associated with the transcription of the immediate downstream beta-like-globin genes. The major DNase I-hypersensitive sites map in what appear to be the 5' and 3' boundary areas of the human beta-like-globin gene domain, a region estimated to span at least 90 kilobases of DNA. These major sites are present in various erythroid cells, which express predominantly either the embryonic, the fetal, or the adult beta-like-globin genes, and seem to be involved in defining the active beta-like-globin genes domain in cells of erythroid lineage. The four major DNase I-hypersensitive sites in the 5' boundary area, when correlated with sequencing data, are shown to be located in DNA regions containing enhancer core-like sequences and alternating purine and pyrimidine bases.
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The mammalian β-globin locus developmental β-globin genes are regulated by a powerful tissue-specific enhancer known as a locus control region (LCR).
“These models were initially applied to the mammalian β-globin locus, in which the developmental β-globin genes are regulated by a powerful tissue-specific enhancer known as a locus control region (LCR) [254–257].”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [254]
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- Authors
- Tuan, D., Solomon, W., Li, Q., & London, I. M.
- Affiliations
- Massachusetts Institute of Technology (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1985-10
- Volume
- 82
- Issue
- 19
- Pages
- 6384-6388
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC390720
- OpenAlex
- W2055643269
- Cited by
- 601
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 6
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am016272-14, 5r01am020120-09)
- National Institute of General Medical Sciences (GM-20069)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- beta-globin gene cluster, DNase I hypersensitive sites, erythroid cells, gene expression regulation, transcriptional regulation, globin gene expression
- MeSH terms
- Base Sequence, Bone Marrow, Cell Line, Deoxyribonuclease I, DNA, Leukemia, Erythroblastic, Acute, Gene Expression Regulation, Globins, Humans, Leukemia, Myeloid, Sequence Homology, Nucleic Acid, Leukemia, Myeloid, Acute
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