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Fast Axonal Transport in Extruded Axoplasm from Squid Giant Axon
Abstract
Development of video-enhanced contrast-differential interference contrast for light microscopy has permitted study of both orthograde and retrograde fast axonal transport of membranous organelles in the squid giant axon. This process was found to continue normally for hours after the axoplasm was extruded from the giant axon and removed from the confines of the axonal plasma membrane. It is now possible to follow the movements of the full range of membranous organelles (30-nanometer vesicles to 5000-nanometer mitochondria) in a preparation that lacks a plasma membrane or other permeability barrier. This observation demonstrates that the plasma membrane is not required for fast axonal transport and suggests that action potentials are not involved in the regulation of fast transport. Furthermore, the absence of a permeability barrier surrounding the axoplasm makes this an important model for direct biochemical pharmacological, and physical manipulations of membranous organelle transport.
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Cited by
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993
Axonal transport deficits and neurodegenerative diseases
Millecamps, S., & Julien, J.-P. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3380 · Cited by 755
Axonal transport: cargo-specific mechanisms of motility and regulation
Maday, S., Twelvetrees, A. E., Moughamian, A. J., & Holzbaur, E. L. F. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.019 · Cited by 683
Hirokawa, N., Pfister, K. K., Yorifuji, H., Wagner, M. C., Brady, S. T., & Bloom, G. S. (1989) · Cell · doi:10.1016/0092-8674(89)90691-0 · Cited by 477
Self-citationAllen, R. D., Weiss, D. G., Hayden, J. H., Brown, D. T., Fujiwake, H., & Simpson, M. (1985) · The Journal of cell biology · doi:10.1083/jcb.100.5.1736 · Cited by 441
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Metadata
- Authors
- Brady, S. T., Lasek, R. J., & Allen, R. D.
- Venue
- Science
- Published
- 1982-12-10
- Volume
- 218
- Issue
- 4577
- Pages
- 1129-1131
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036698502
- Cited by
- 339
- References
- 0
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- closed
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