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Cited by 683Nerve injury and regenerationHereditary Neurological DisordersCellular transport and secretion

Axonal transport: cargo-specific mechanisms of motility and regulation

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Maday, Sandra, Twelvetrees, Alison E., Moughamian, Armen J., Holzbaur, Erika L.F.·2014·Neuron
DOI 10.1016/j.neuron.2014.10.019PMC PMC4269290
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Abstract

Axonal transport is essential for neuronal function, and many neurodevelopmental and neurodegenerative diseases result from mutations in the axonal transport machinery. Anterograde transport supplies distal axons with newly synthesized proteins and lipids, including synaptic components required to maintain presynaptic activity. Retrograde transport is required to maintain homeostasis by removing aging proteins and organelles from the distal axon for degradation and recycling of components. Retrograde axonal transport also plays a major role in neurotrophic and injury response signaling. This review provides an overview of axonal transport pathways and discusses their role in neuronal function.

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  • SCARB2 has been identified in several PD risk genome-wide association studies.

    “SCARB2 has been identified in several PD risk genome-wide association studies (GWAS).100–103”

    From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [103]

    The retrieved passages from the paper’s References section concern axonal transport and other neurological conditions, not SCARB2 or Parkinson’s disease risk GWAS. Searches for SCARB2, GWAS, and the claimed association found no passage in our copy addressing it. (LLM, conf=0.73)

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Authors
Maday, S., Twelvetrees, A. E., Moughamian, A. J., & Holzbaur, E. L. F.
Affiliations
University of Pennsylvania (US)
Corresponding author
Holzbaur, Erika L.F.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2014-10
Volume
84
Issue
2
Pages
292-309
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2014.10.019
PMC
PMC4269290
OpenAlex
W2039919932
Cited by
683
References
17
Citations by year
2026: 38 · 2025: 54 · 2024: 51 · 2023: 41 · 2022: 75 · 2021: 74 · 2020: 82 · 2019: 56 · 2018: 67 · 2017: 57 · 2016: 53 · 2015: 34 · 2014: 1
FWCI
5.52
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Wellcome Trust (096141/Z/11/Z)
  • National Institutes of Health
  • National Institute on Aging (T32AG000255)
  • National Institute of Neurological Disorders and Stroke (F31NS073196, K99NS082619, R37NS060698)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
axonal transport, anterograde transport, retrograde transport, neuronal function, neurodegenerative diseases, neurodevelopmental disorders, synaptic proteins, protein degradation, organelle recycling, neurotrophic signaling
MeSH terms
Animals, Axons, Axonal Transport, Humans, Neurons, Organelles, Signal Transduction, Neurodegenerative Diseases

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