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Cited by 326

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Properties of a Normal Mouse Cell DNA Sequence (sarc) Homologous to the src Sequence of Moloney Sarcoma Virus

Oskarsson, Marianne, McClements, William L., Blair, Donald G., Maizel, J. V., Vande Woude, George F.·1980·Science

Abstract

A 15.0-kilobase (kb) Eco RI DNA fragment from normal mouse Balb/c genomic DNA that contains sequences (sarc) homologous to the acquired cell sequences (src) of Moloney sarcoma virus (MSV) has been cloned in phage λ. The sarc region (1.2 to 1.3 kb) of the 15.0-kb cell fragment is indistinguishable from the src region of two isolates of MSV as judged by heteroduplex and restriction endonuclease analyses. The cellular sequences flanking sarc show no homology to other MSV sequences. Whereas cloned subgenomic portions of MSV that contain src transformed NIH-3T3 cells in vitro, the cloned sarc fragment is inactive.

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Crossref · 10.1126/science.6243788

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Metadata

Authors
Oskarsson, M., McClements, W. L., Blair, D. G., Maizel, J. V., & Vande Woude, G. F.
Venue
Science
Published
1980-03-14
Volume
207
Issue
4436
Pages
1222-1224
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2003591463
Cited by
326
References
1
FWCI
22.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Properties of a Normal Mouse Cell DNA Sequence (sarc) Homologous to the src Sequence of Moloney Sarcoma Virus. https://app.cochat.ai/papers/10.1126/science.6243788
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Oskarsson, M., McClements, W. L., Blair, D. G., Maizel, J. V., & Vande Woude, G. F. (1980). Properties of a Normal Mouse Cell DNA Sequence (sarc) Homologous to the src Sequence of Moloney Sarcoma Virus. Science. https://doi.org/10.1126/science.6243788

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.