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Cellular Transforming Genes
Abstract
Cellular genes potentially capable of inducing oncogenic transformation have been identified by homology to the transforming genes of retroviruses and by the biological activity of cellular DNA's in transfection assays. DNA's of various tumors induce transformation with high efficiencies, indicating that oncogenesis can involve dominant genetic alterations resulting in activation of cellular transforming genes. The identification and characterization of cellular transforming genes and their possible involvement in naturally occurring cancers, is discussed.
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Cited by
Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
Cavenee, W. K., Dryja, T. P., Phillips, R. A., Benedict, W. F., Godbout, R., Gallie, B. L., Murphree, A. L., Strong, L. C., & White, R. L. (1983) · Nature · doi:10.1038/305779a0 · Cited by 1,920
Activation of a novel human transforming gene, ret, by DNA rearrangement
Takahashi, M., Ritz, J., & Cooper, G. M. (1985) · Cell · doi:10.1016/0092-8674(85)90115-1 · Cited by 854
Self-citationGrowth factors: Mechanism of action and relation to oncogenes
Heldin, C.-H., & Westermark, B. (1984) · Cell · doi:10.1016/0092-8674(84)90296-4 · Cited by 854
Purification of DNA from formaldehyde fixed and paraffin embedded human tissue
Goelz, S. E., Hamilton, S. R., & Vogelstein, B. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)90390-0 · Cited by 803
DNA repair, genome stability and cancer: a historical perspective
Jeggo, P. A., Pearl, L. H., & Carr, A. M. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2015.4 · Cited by 774
Metadata
- Authors
- Cooper, G. M.
- Venue
- Science
- Published
- 1982-08-27
- Volume
- 217
- Issue
- 4562
- Pages
- 801-806
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2011857798
- Cited by
- 606
- References
- 0
- FWCI
- 68.58
- Type
- journal article
- Language
- en
- Open access
- closed
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