The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Stress-Induced Analgesia in Humans: Endogenous Opioids and Naloxone-Reversible Depression of Pain Reflexes
Abstract
The cumulative effects of a repetitive stress induced by anticipation of pain (noxious foot shock) were studied on the threshold of a nociceptive flexion reflex of the lower limb. The threshold of the nociceptive reflex progressively increased with the repetition of the stress. This effect was reversed by naloxone, which even produced hyperalgesia, since a rapid and significant decrease in this threshold, below the initial values, was noted. The data provide evidence for involvement of endogenous opioids in the phenomenon of stress-induced analgesia in normal man.
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Citations
Cites
Comparative study of perceived pain and nociceptive flexion reflex in man
de Willer, J. C. (1977) · Pain · doi:10.1016/0304-3959(77)90036-7 · Cited by 559
Stress-induced parallel changes in central opioid levels and pain responsiveness in the rat
MADDEN, J., AKIL, H., PATRICK, R. L., & BARCHAS, J. D. (1977) · Nature · doi:10.1038/265358a0 · Cited by 559
The two-arousal hypothesis: Reticular formation and limbic system.
Routtenberg, A. (1968) · Psychological Review · doi:10.1037/h0025303 · Cited by 386
Supraspinal influences on nociceptive flexion reflex and pain sensation in man
Miller, J. C., Boureau, F., & Albe-Fessard, D. (1979) · Brain Research · doi:10.1016/0006-8993(79)90489-x · Cited by 229
Naloxone Increases ACTH and Cortisol Levels in Man
(1979) · New England Journal of Medicine · doi:10.1056/nejm197905033001817 · Cited by 188
Fratta, W., Yang, H., Hong, J., & Costa, E. (1977) · Nature · doi:10.1038/268452a0 · Cited by 139
Willer, J. C., Boureau, F., & Albe-Fessard, D. (1978) · Brain Research · doi:10.1016/0006-8993(78)90264-0 · Cited by 90
Self-citationStudy of naloxone in normal awake man: Effects on heart rate and respiration
Jc, W., Boureau, F., Dauthier, C., & Bonora, M. (1979) · Neuropharmacology · doi:10.1016/0028-3908(79)90072-8 · Cited by 57
Willer, J. C. (1975) · Physiology & Behavior · doi:10.1016/0031-9384(75)90251-6 · Cited by 52
Self-citationJc, W. (1975) · Physiology & Behavior · doi:10.1016/0031-9384(75)90206-1 · Cited by 46
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The functions of deliberate self-injury: a review of the evidence
Klonsky, E. D. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.08.002 · Cited by 1,979
Fear and anxiety: divergent effects on human pain thresholds
Rhudy, J. L., & Meagher, M. W. (2000) · Pain · doi:10.1016/s0304-3959(99)00183-9 · Cited by 913
Self-injurious behavior: a review of the behavior and biology of self- mutilation
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.3.306 · Cited by 431
Cerebral perturbations provoked by prolonged exercise
Nybo, L., & Secher, N. H. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.005 · Cited by 398
Frontiers in pruritus research: scratching the brain for more effective itch therapy
Paus, R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28553 · Cited by 373
Metadata
- Authors
- Willer, J. C., Dehen, H., & Cambier, J.
- Venue
- Science
- Published
- 1981-05-08
- Volume
- 212
- Issue
- 4495
- Pages
- 689-691
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077006721
- Cited by
- 334
- References
- 10
- FWCI
- 22.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Stress-Induced Analgesia in Humans: Endogenous Opioids and Naloxone-Reversible Depression of Pain Reflexes. https://app.cochat.ai/papers/10.1126/science.6261330
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- Willer, J. C., Dehen, H., & Cambier, J. (1981). Stress-Induced Analgesia in Humans: Endogenous Opioids and Naloxone-Reversible Depression of Pain Reflexes. Science. https://doi.org/10.1126/science.6261330
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
