The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Synaptic Excitation May Activate a Calcium-Dependent Potassium Conductance in Hippocampal Pyramidal Cells
Abstract
In hippocampal CA1 pyramidal cells, orthodromic synaptic excitation is followed by an early hyperpolarization mediated by γ-aminobutyric acid (GABA) and a late non-GABA-mediated hyperpolarization that has properties consistent with an increase in potassium conductance. Depolarizations produced by iontophoretically applied glutamate are followed by hyperpolarizations that have features in accordance with an increase in potassium conductance. The hyperpolarizations are independent of chloride and resistant to tetrodotoxin but are blocked by a low-calcium, high-cobalt medium. Voltage clamping the glutamate depolarization does not reduce the subsequent hyperpolarization, indicating that the hyperpolarization results from a direct increase in calcium conductance produced by glutamate, rather than from activation of voltage-sensitive calcium channels. A single transmitter, possibly acting on one type of receptor and channel, may initiate both excitation and inhibition in the same postsynaptic cell.
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Citations
Cites
A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons
Hotson, J. R., & Prince, D. A. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.2.409 · Cited by 569
Cited by
Ylinen, A., Bragin, A., Nadasdy, Z., Jando, G., Szabo, I., Sik, A., & Buzsaki, G. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00030.1995 · Cited by 1,092
Hippocampal sharp waves: Their origin and significance
Buzsáki, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)91483-6 · Cited by 925
Prenatal malnutrition and development of the brain
Morgane, P. J., Austin-LaFrance, R., Bronzino, J., Tonkiss, J., Díaz-Cintra, S., Cintra, L., Kemper, T., & Galler, J. R. (1993) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80234-9 · Cited by 667
The thalamus as a neuronal oscillator
STERIADE, M., & DESCHENES, M. (1984) · Brain Research Reviews · doi:10.1016/0165-0173(84)90017-1 · Cited by 653
Feed‐forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro
Alger, B. E., & Nicoll, R. A. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014255 · Cited by 527
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Metadata
- Authors
- Nicoll, R. A., & Alger, B. E.
- Venue
- Science
- Published
- 1981-05-22
- Volume
- 212
- Issue
- 4497
- Pages
- 957-959
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059188064
- Cited by
- 194
- References
- 1
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nicoll, R. A., & Alger, B. E. (1981). Synaptic Excitation May Activate a Calcium-Dependent Potassium Conductance in Hippocampal Pyramidal Cells. Science. https://doi.org/10.1126/science.6262912
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
