A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons

Hotson, J. R.; Prince, D. A.

doi:10.1152/jn.1980.43.2.409

Cited by 572Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias

A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons

Hotson, J. R., Prince, D. A.·1980·Journal of Neurophysiology

DOI 10.1152/jn.1980.43.2.409

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Abstract

1. A long-lasting afterhyperpolarization (AHP) follows current-induced repetitive firing in hippocampal CA1 neurons studied in vitro. A 10-25% increase in membrane slope conductance occurs during the AHP, suggesting that it may be mediated by an increased conductance to either K+ or Cl-. 2. Intracellular Cl- iontophoresis does not alter the AHP but does attenuate the IPSP. In contrast Ba2+, a cation that can decrease K+ conductance, eliminates the AHP but not the IPSP. These findings suggest the AHP is produced by a long-lasting increased conductance to K+, and is distinct from the IPSP. 3. Mn2+, a Ca2+-channel blocker, eliminates the AHP. In comparison, the AHP persists in the presence of the Na+-channel blocker, tetrodotoxin (TTX), and appears to be temporally associated with TTX-resistant "Ca2+ spikes." It is concluded that AHP is probably activated by Ca2+ influx. 4. These observations indicate that the AHP may be produced by a Ca2+ activated K+ current. A balance between cellular depolarization produced by Ca2+ entry and repolarization generated by a Ca2+-activated K+ current appears to operate to control excitability in some mammalian cortical neurons as it does in molluscan neurons. Disruption of this balance by Ba2+ produces spontaneous membrane-potential oscillations and recurrent burst firing in hippocampal neurons. Increases in the magnitude and duration of Ca2+ depolarization and/or decreases in the Ca2+-activated, K+-mediated repolarization may be mechanisms that lead to spontaneous, epileptiform bursting in mammalian cortical neurons.

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AHP currents are mainly mediated by calcium-dependent potassium channels, but also partly by calcium-independent potassium channels.
“AHP currents are mainly mediated by calcium-dependent potassium channels [77, 78], but also partly by calcium-independent potassium channels [79].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [78]

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Authors: Hotson, J. R., & Prince, D. A.
Venue: Journal of Neurophysiology
Publisher: American Physiological Society
Published: 1980-02-01
Volume: 43
Issue: 2
Pages: 409-419
ISSN: 0022-3077 (ISSN-L)
1522-1598
DOI: 10.1152/jn.1980.43.2.409
OpenAlex: W1953088445
Cited by: 569
References: 0
Citations by year: 2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 8 · 2012: 10
FWCI: 13.56
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neurophysiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: afterhyperpolarization, CA1 pyramidal neurons, repetitive firing, calcium-activated potassium current, calcium influx, membrane conductance, barium block, manganese block, tetrodotoxin, calcium spikes, inhibitory postsynaptic potentials, membrane potential oscillations, burst firing, epileptiform bursting, neuronal excitability
MeSH terms: Action Potentials, Animals, Barium, Calcium, Chlorides, Electric Stimulation, Guinea Pigs, Hippocampus, Ion Channels, Manganese, Membrane Potentials, Potassium, Tetrodotoxin, In Vitro Techniques

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A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons

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