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Electrotonic Coupling Between Pyramidal Cells: A Direct Demonstration in Rat Hippocampal Slices
Abstract
Intracellular recordings from pairs of neurons in slices of rat hippocampus directly demonstrated electrotonic coupling between CA3 pyramidal cells. When two neurons were impaled simultaneously (as verified by subsequent double staining with horseradish peroxidase), current pulses injected into one cell caused voltage changes in other cells. These interactions were bidirectional. Fast prepotentials, historically thought to represent spike activity in dendrites, resulted from action potentials in other electrotonically coupled pyramidal cells. These data directly demonstrate electrotonic coupling between neurons in the mammalian brain and indicate that some fast prepotentials are coupling potentials. Coupling between pyramidal cells could mediate synchronization of normal rhythmic activity and of burst discharges during seizures.
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Cited by
Hippocampal sharp waves: Their origin and significance
Buzsáki, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)91483-6 · Cited by 925
ELECTRICAL SYNAPSES IN THE MAMMALIAN BRAIN
Connors, B. W., & Long, M. A. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131128 · Cited by 784
Action potential initiation and backpropagation in neurons of the mammalian CNS
Stuart, G., Spruston, N., Sakmann, B., & Häusser, M. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10075-8 · Cited by 768
Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro
Draguhn, A., Traub, R. D., Schmitz, D., & Jefferys, J. G. R. (1998) · Nature · doi:10.1038/28184 · Cited by 703
Interictal spikes in focal epileptogenesis
de Curtis, M., & Avanzini, G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00026-5 · Cited by 477
Metadata
- Authors
- MacVicar, B. A., & Dudek, F. E.
- Venue
- Science
- Published
- 1981-08-14
- Volume
- 213
- Issue
- 4509
- Pages
- 782-785
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2063134736
- Cited by
- 328
- References
- 0
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- MacVicar, B. A., & Dudek, F. E. (1981). Electrotonic Coupling Between Pyramidal Cells: A Direct Demonstration in Rat Hippocampal Slices. Science. https://doi.org/10.1126/science.6266013
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