Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro
Abstract
Coherent oscillations, in which ensembles of neurons fire in a repeated and synchronous manner, are thought to be important in higher brain functions. In the hippocampus, these discharges are categorized according to their frequency as theta (4-10Hz), gamma (20-80 Hz) and high-frequency (approximately 200 Hz) discharges, and they occur in relation to different behavioural states. The synaptic bases of theta and gamma rhythms have been extensively studied but the cellular bases for high-frequency oscillations are not understood. Here we report that high-frequency network oscillations are present in rat brain slices in vitro, occurring as a brief series of repetitive population spikes at 150-200 Hz in all hippocampal principal cell layers. Moreover, this synchronous activity is not mediated through the more commonly studied modes of chemical synaptic transmission, but is in fact a result of direct electrotonic coupling of neurons, most likely through gap-junctional connections. Thus high-frequency oscillations synchronize the activity of electrically coupled subsets of principal neurons within the well-documented synaptic network of the hippocampus.
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Beginning in 1998, evidence began to show that gamma synchrony, the best measurable correlate of consciousness, depended on gap junctions, particularly dendritic-dendritic gap junctions.
“Beginning in 1998, evidence began to show that gamma synchrony, the best measurable correlate of consciousness, depended on gap junctions, particularly dendritic-dendritic gap junctions [49][50][51][52][53][54].”
From Consciousness in the universe (2014) · cites this paper as [50]
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- Authors
- Draguhn, A., Traub, R. D., Schmitz, D., & Jefferys, J. G. R.
- Affiliations
- University of Birmingham (GB)
- Humboldt-Universität zu Berlin (DE)
- Corresponding author
- Draguhn, A.
- Venue
- Nature
- Published
- 1998-07
- Volume
- 394
- Issue
- 6689
- Pages
- 189-192
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2030670571
- Cited by
- 703
- References
- 31
- Citations by year
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- FWCI
- 20.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- high-frequency oscillations, hippocampus, electrical coupling, gap junctions, neuronal synchronization, population spike, gamma oscillations, theta oscillations, brain slices
- MeSH terms
- Action Potentials, Animals, Bicuculline, Calcium, Female, Hippocampus, Male, Neurons, Oscillometry, Rats, Wistar, Gap Junctions, Excitatory Amino Acid Antagonists, GABA Antagonists, Rats, In Vitro Techniques
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