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Cloned Viral Protein Vaccine for Foot-and-Mouth Disease: Responses in Cattle and Swine
Abstract
A DNA sequence coding for the immunogenic capsid protein VP 3 of foot-and-mouth disease virus A 12 , prepared from the virion RNA, was ligated to a plasmid designed to express a chimeric protein from the Escherichia coli tryptophan promoter-operator system. When Escherichia coli transformed with this plasmid was grown in tryptophan-depleted media, approximately 17 percent of the total cellular protein was found to be an insoluble and stable chimeric protein. The purified chimeric protein competed equally on a molar basis with VP 3 for specific antibodies to foot-and-mouth disease virus. When inoculated into six cattle and two swine, this protein elicited high levels of neutralizing antibody and protection against challenge with foot-and-mouth disease virus.
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Citations
Cited by
The purification of eukaryotic polypeptides synthesized in Escherichia coli
Marston, F. A. (1986) · Biochemical Journal · doi:10.1042/bj2400001 · Cited by 836
KAR3, a kinesin-related gene required for yeast nuclear fusion
Meluh, P. (1990) · Cell · doi:10.1016/0092-8674(90)90351-e · Cited by 503
Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus.
Pfaff, E., Mussgay, M., Böhm, H. O., Schulz, G. E., & Schaller, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01262.x · Cited by 361
De novo design of the hydrophobic cores of proteins
Desjarlais, J. R., & Handel, T. M. (1995) · Protein Science · doi:10.1002/pro.5560041006 · Cited by 306
Haarer, B. K., & Pringle, J. R. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.10.3678 · Cited by 275
Metadata
- Authors
- Kleid, D. G., Yansura, D., Small, B., Dowbenko, D., Moore, D. M., Grubman, M. J., McKercher, P. D., Morgan, D. O., Robertson, B. H., & Bachrach, H. L.
- Venue
- Science
- Published
- 1981-12-04
- Volume
- 214
- Issue
- 4525
- Pages
- 1125-1129
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089726928
- Cited by
- 498
- References
- 0
- FWCI
- 64.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kleid, D. G., Yansura, D., Small, B., Dowbenko, D., Moore, D. M., Grubman, M. J., McKercher, P. D., Morgan, D. O., Robertson, B. H., & Bachrach, H. L. (1981). Cloned Viral Protein Vaccine for Foot-and-Mouth Disease: Responses in Cattle and Swine. Science. https://doi.org/10.1126/science.6272395
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