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Oxytocin Receptors and Human Parturition: A Dual Role for Oxytocin in the Initiation of Labor
Abstract
The concentration of oxytocin receptors increased in the myometrium of pregnant women and reached maximum levels in early labor. Concentrations of oxytocin receptors were also high in the decidua and reached a maximum at parturition. In vitro, prostaglandin production by the decidua, but not by the myometrium, was increased by the addition of oxytocin. Oxytocin may therefore stimulate uterine contractions by acting both directly on the myometrium and indirectly on decidual prostaglandin production. Oxytocin receptors are probably crucial for the onset of human labor, and the stimulus for the increase in uterine prostaglandins may be oxytocin originating from the fetus.
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Citations
Cited by
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Endocrine and Paracrine Regulation of Birth at Term and Preterm*
Challis, J. R. G., Matthews, S. G., Gibb, W., & Lye, S. J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0407 · Cited by 995
Plasma oxytocin increases in the human sexual response
CARMICHAEL, M. S., HUMBERT, R., DIXEN, J., PALMISANO, G., GREENLEAF, W., & DAVIDSON, J. M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-27 · Cited by 554
Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted?
McCullough, M. E., Churchland, P. S., & Mendez, A. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.018 · Cited by 416
Carter, C. S. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80176-9 · Cited by 417
Metadata
- Authors
- Fuchs, A.-R., Fuchs, F., Husslein, P., Soloff, M. S., & Fernström, M. J.
- Venue
- Science
- Published
- 1982-03-12
- Volume
- 215
- Issue
- 4538
- Pages
- 1396-1398
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084324077
- Cited by
- 492
- References
- 0
- FWCI
- 29.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Oxytocin Receptors and Human Parturition: A Dual Role for Oxytocin in the Initiation of Labor. https://app.cochat.ai/papers/10.1126/science.6278592
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- Fuchs, A.-R., Fuchs, F., Husslein, P., Soloff, M. S., & Fernström, M. J. (1982). Oxytocin Receptors and Human Parturition: A Dual Role for Oxytocin in the Initiation of Labor. Science. https://doi.org/10.1126/science.6278592
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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