Spectral Character of Sunlight Modulates Photosynthesis of Previtamin D 3 and Its Photoisomers in Human Skin
Abstract
The photosynthesis of previtamin D 3 from 7-dehydrocholesterol in human skin was determined after exposure to narrow-band radiation or simulated solar radiation. The optimum wavelengths for the production of previtamin D 3 were determined to be between 295 and 300 nanometers. When human skin was exposed to 295-nanometer radiation, up to 65 percent of the original 7-dehydrocholesterol content was converted to previtamin D 3 . In comparison, when adjacent skin was exposed to simulated solar radiation, the maximum formation of previtamin D 3 was about 20 percent. Major differences in the formation of lumisterol 3 and tachysterol 3 from previtamin D 3 were also observed. It is concluded that the spectral character of natural sunlight has a profound effect on the photochemistry of 7-dehydrocholesterol in human skin.
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UV can elicit the synthesis of vitamin D, an important molecule in calcium homeostasis of various types of skin cells contributing to DNA repair and immunomodulation.
“Furthermore, UV can elicit the synthesis of vitamin D, an important molecule in calcium homeostasis of various types of skin cells contributing to DNA repair and immunomodulation.”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [81]
Many cell types outside the skeletal system, including various cells in the skin, express the vitamin D receptor and convert circulating 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D for local use.
“On the other hand, many cell types outside of the skeletal system, including various cells in the skin, also express the vitamin D receptor. Those cell types convert circulating 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D for local use [81].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [81]
Vitamin D is best synthesized by the skin following UVB exposure, and this synthesis may vary among individuals with different skin types.
“Vitamin D is best synthesized by the skin following UVB exposure [81] and this synthesis may vary among individuals with different skin types [82].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [81]
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Neville, J. J., Palmieri, T., & Young, A. R. (2021) · JBMR Plus · doi:10.1002/jbm4.10460 · Cited by 83 · see citing works
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Self-citationVitamin D3 synthesis in the entire skin surface of dairy cows despite hair coverage
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Influence of narrowband UVB phototherapy on vitamin D and folate status
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Characterization of the translocation process of vitamin D3 from the skin into the circulation
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Self-citationSpectral, Irradiance, and Temporal Aspects of Natural and Artificial Light
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Ultraviolet B Radiation: The Vitamin D Connection
Holick, M. F. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-56017-5_12 · Cited by 76 · see citing works
Self-citationVitamin D in cutaneous carcinogenesis
Tang, J. Y., Fu, T., Lau, C., Oh, D. H., Bikle, D. D., & Asgari, M. M. (2012) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2012.07.022 · Cited by 74 · see citing works
- Authors
- MacLaughlin, J. A., Anderson, R. R., & Holick, M. F.
- Affiliations
- Massachusetts General Hospital (US)
- ORCID
- Holick, M. F.
- Venue
- Science
- Published
- 1982-05-28
- Volume
- 216
- Issue
- 4549
- Pages
- 1001-1003
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2017458967
- Cited by
- 539
- References
- 10
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 11 · 2023: 15 · 2022: 8 · 2021: 23 · 2020: 20 · 2019: 15 · 2018: 19 · 2017: 22 · 2016: 25 · 2015: 23 · 2014: 29 · 2013: 22 · 2012: 31
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- previtamin D3, 7-dehydrocholesterol, vitamin D synthesis, human skin, solar spectrum, narrow-band radiation, simulated solar radiation, lumisterol, tachysterol, photoisomers, photochemistry, ultraviolet radiation
- MeSH terms
- Cholecalciferol, Dehydrocholesterols, Ergosterol, Humans, Isomerism, Photochemistry, Skin, Spectrum Analysis, Structure-Activity Relationship, Ultraviolet Rays, In Vitro Techniques
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