The DOI matches its Crossref record.
Benzodiazepine Receptor-Mediated Experimental "Anxiety" in Primates
Abstract
The ethyl ester of β-carboline-3-carboxylic acid has a high affinity for benzodiazepine receptors in the brain. In the rhesus monkey this substance produces an acute behavioral syndrome characterized by dramatic elevations in heart rate, blood pressure, plasma cortisol, and catecholamines. The effects are blocked by benzodiazepines and the specific benzodiazepine receptor antagonist Ro 15-1788. The benzodiazepine receptor may consist of several subsites or functional domains that independently recognize agonists, antagonists, or "active" antagonists such as β-carboline-3-carboxylic acid ethyl ester. These results suggest that the benzodiazepine receptor is involved in both the affective and physiological manifestations of anxiety, and that the administration of β-carboline-3-carboxylic acid ethyl ester to monkeys may provide a reliable and reproducible animal model of human anxiety.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Murphy, B. L., Arnsten, A. F., Goldman-Rakic, P. S., & Roth, R. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1325 · Cited by 590
Benzodiazepine impairs and β-carboline enhances performance in learning and memory tasks
Venault, P., Chapouthier, G., de Carvalho, L. P., Simiand, J., Morre, M., Dodd, R. H., & Rossier, J. (1986) · Nature · doi:10.1038/321864a0 · Cited by 503
Chapter 19 The determinants of stress-induced activation of the prefrontal cortical dopamine system
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62691-6 · Cited by 364
Environmentally-induced modification of the benzodiazepine/GABA receptor coupled chloride ionophore
Trullas, R., Havoundjian, H., Zamir, N., Paul, S., & Skolnick, P. (1987) · Psychopharmacology · doi:10.1007/bf00518197 · Cited by 78
Self-citationCharacterization of the Binding of [3H]Ro 5‐4864, a Convulsant Benzodiazepine, to Guinea Pig Brain
Weissman, B. A., Bolger, G. T., Isaac, L., Paul, S. M., & Skolnick, P. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb12698.x · Cited by 64
Self-citation
Metadata
- Authors
- Ninan, P. T., Insel, T. M., Cohen, R. M., Cook, J. M., Skolnick, P., & Paul, S. M.
- Venue
- Science
- Published
- 1982-12-24
- Volume
- 218
- Issue
- 4579
- Pages
- 1332-1334
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994051978
- Cited by
- 316
- References
- 0
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Benzodiazepine Receptor-Mediated Experimental "Anxiety" in Primates. https://app.cochat.ai/papers/10.1126/science.6293059
- The paper
- Ninan, P. T., Insel, T. M., Cohen, R. M., Cook, J. M., Skolnick, P., & Paul, S. M. (1982). Benzodiazepine Receptor-Mediated Experimental "Anxiety" in Primates. Science. https://doi.org/10.1126/science.6293059
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
