Chapter 19 The determinants of stress-induced activation of the prefrontal cortical dopamine system
Open accessAbstract
The dopamine (DA) innervation of the prefrontal cortex (PFC) differs from other mesotelencephalic DA terminal field regions in that it responds in a quantitatively different manner to a number of pharmacological and environmental manipulations. The quantitatively different response characteristics of the PFC DA system and the resultant pattern of changes across the mesotelencephalic DA terminal fields presumably reflect differences in the regulatory features of mesencephalic neurons, which give rise to the DA innervations of different forebrain regions. The regulatory controls involved in the normal impulse-dependent release of DA from the nerve terminal range from intrinsic regulatory features to extrinsic regulatory features. This chapter explores the features of mesoprefrontal cortical DA neurons that render their response characteristics to a number of pharmacological and environmental challenges different from those of other mesotelencephalic DA neurons by using stress-induced alterations in mesotelencephalic DA neurons as a model. It also examines both the similarities and differences between DA neurons projecting to the PFC and those innervating other telencephalic sites.
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Both dopamine and norepinephrine release are increased in the medial PFC during acute stress exposure in rats.
“Biochemical studies in rats have consistently shown that both DA and NA release are increased in the medial PFC during acute stress exposure (30–32).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [31]
In addition to global increases in glucocorticoids, stress increases catecholamine release in PFC.
“In addition to global increases in glucocorticoids, stress increases catecholamine release in PFC19,24,45.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [45]
Stress results in altered release of dopamine in the nucleus accumbens (striatum), the primary reward system within the brain.
“Stress also results in altered release of dopamine in the nucleus accumbens (striatum), the primary reward system within the brain (Deutch and Roth 1990).”
From The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology (2006) · cites this paper as Deutch and Roth 1990
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- Authors
- Deutch, A. Y., & Roth, R. H.
- Affiliations
- Yale University (US)
- Corresponding author
- Ariel Y. Deutch
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 1991
- Volume
- 85
- Pages
- 367-403
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W989040792
- Cited by
- 364
- References
- 2
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 14 · 2013: 8 · 2012: 11
- FWCI
- 19.58
- Type
- book chapter
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Progress in brain research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH045124, MH-45124, MH14092)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- prefrontal cortex, dopamine, mesocortical dopamine system, stress, dopaminergic neurons
- MeSH terms
- Animals, Benzodiazepines, Dopamine, Frontal Lobe, Neurons, Stress, Physiological
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