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Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?
Open accessAbstract
The concentration of cytosolic ionized calcium, [Ca 2+ ] i , was measured in intact neutrophils by use of a fluorescent indicator trapped in the cytoplasm. A given rise of [Ca 2+ ] i elicited by the chemotactic peptide formylmethionylleucylphenylalanine (FMLP) was associated with a much greater degree of superoxide generation and myeloperoxidase secretion than was the same or larger [Ca 2+ ] i produced by a specific calcium ionophore, ionomycin, which bypasses cell surface receptors. Thus, FMLP appears to generate some important excitatory signal in addition to a rise in [Ca 2+ ] i , and exocytosis and superoxide generation in neutrophils may not be simply dependent on [Ca 2+ ] i as is widely supposed.
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Cited by
The O2−-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function
Rossi, F. (1986) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(86)90005-4 · Cited by 658
Heyworth, P. G., Cross, A. R., & Curnutte, J. T. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(03)00109-2 · Cited by 396
Calcium Gradients Underlying Polarization and Chemotaxis of Eosinophils
Brundage, R. A., Fogarty, K. E., Tuft, R. A., & Fay, F. S. (1991) · Science · doi:10.1126/science.1948048 · Cited by 294
Vorobjeva, N., Galkin, I., Pletjushkina, O., Golyshev, S., Zinovkin, R., Prikhodko, A., Pinegin, V., Kondratenko, I., Pinegin, B., & Chernyak, B. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165664 · Cited by 136
Metadata
- Authors
- Pozzan, T., Lew, D. P., Wollheim, C. B., & Tsien, R. Y.
- Venue
- Science
- Published
- 1983-09-30
- Volume
- 221
- Issue
- 4618
- Pages
- 1413-1415
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964577086
- Cited by
- 461
- References
- 0
- FWCI
- 19.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Pozzan, T., Lew, D. P., Wollheim, C. B., & Tsien, R. Y. (1983). Is Cytosolic Ionized Calcium Regulating Neutrophil Activation? Science. https://doi.org/10.1126/science.6310757
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