The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Calcium Gradients Underlying Polarization and Chemotaxis of Eosinophils
Abstract
The concentration of intracellular free calcium ([Ca 2+ ] i ) in polarized eosinophils was imaged during chemotaxis by monitoring fluorescence of the calcium-sensitive dye Fura-2 with a modified digital imaging microscope. Chemotactic stimuli caused [Ca 2+ ] i to increase in a nonuniform manner that was related to cell activity. In cells moving persistently in one direction, [Ca 2+ ] i was highest at the rear and lowest at the front of the cell. Before cells turned, [Ca 2+ ] i transiently increased. The region of the cell that became the new leading edge had the lowest [Ca 2+ ] i . These changes in [Ca 2+ ] i provide a basis for understanding the organization and local activity of cytoskeletal proteins thought to underlie the directed migration of many cells.
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Cited by
Functional significance of cell volume regulatory mechanisms
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Physiology of cell volume regulation in vertebrates
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Membrane potential and cancer progression
Yang, M., & Brackenbury, W. J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00185 · Cited by 614
Calcium flickers steer cell migration
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Role of Ion Channels and Transporters in Cell Migration
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Metadata
- Authors
- Brundage, R. A., Fogarty, K. E., Tuft, R. A., & Fay, F. S.
- Venue
- Science
- Published
- 1991-11
- Volume
- 254
- Issue
- 5032
- Pages
- 703-706
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075569239
- Cited by
- 294
- References
- 22
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brundage, R. A., Fogarty, K. E., Tuft, R. A., & Fay, F. S. (1991). Calcium Gradients Underlying Polarization and Chemotaxis of Eosinophils. Science. https://doi.org/10.1126/science.1948048
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
