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Anatomically Distinct Opiate Receptor Fields Mediate Reward and Physical Dependence
Abstract
Rats never before exposed to opioids rapidly learned to press a lever for microinjections of morphine into the ventral tegmental area. Challenge by a narcotic antagonist produced no signs of physical dependence. Dependence was not seen after long-term morphine infusions into the ventral tegmentum but was seen after similar infusions into the periventricular gray region. Thus a major rewarding property of morphine is independent of the drug's ability to produce physical dependence. These data challenge models of drug addiction that propose physical dependence as necessary for the rewarding effects of opioids.
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Cited by
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747
Self-citationCellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications
Mansour, A., Fox, C. A., Akil, H., & Watson, S. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93946-u · Cited by 1,292
Wise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072
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Metadata
- Authors
- Bozarth, M. A., & Wise, R. A.
- Venue
- Science
- Published
- 1984-05-04
- Volume
- 224
- Issue
- 4648
- Pages
- 516-517
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2025884351
- Cited by
- 266
- References
- 0
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
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