Neurobiology of addiction

Wise, Roy A

doi:10.1016/s0959-4388(96)80079-1

Cited by 1,072Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

Neurobiology of addiction

Wise, Roy A·1996·Current Opinion in Neurobiology

DOI 10.1016/s0959-4388(96)80079-1

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Abstract

Addictive drugs have habit-forming actions that can be localized to a variety of brain regions. Recent advances in our understanding of the chemical 'trigger zones' in which individual drugs of abuse initiate their habit-forming actions have revealed that such disparate drugs as heroin, cocaine, nicotine, alcohol, phencyclidine, and cannabis activate common reward circuitry in the brain. Although these drugs have many actions that are distinct, their habit-forming actions (and perhaps the relevant elements of their disparate withdrawal symptoms) appear to have a common denominator, namely, similar effects in the brain mechanisms of reward.

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Rewarding effects of such disparate drugs as cocaine, nicotine, heroin, alcohol and cannabis have been suggested to be mediated by a common circuitry.
“Rewarding effects of such disparate drugs as cocaine, nicotine, heroin, alcohol and cannabis have been suggested to be mediated by a common circuitry”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Wise, 1996

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Predictive reward signal of dopamine neurons
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What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
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Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
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Getting formal with dopamine and reward
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The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
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Dopamine and the regulation of cognition and attention
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Subsecond dopamine release promotes cocaine seeking
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Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love
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Reward processing in primate orbitofrontal cortex and basal ganglia
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Neurobiology of relapse to heroin and cocaine seeking: a review
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Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses
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Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
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Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers
Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632 · see citing works
Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence
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Alcohol promotes dopamine release in the human nucleus accumbens
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Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles
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Treating Drug Abuse and Addiction in the Criminal Justice System: Improving Public Health and Safety
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Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies
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Neurobiologic processes in drug reward and addiction
Adinoff, B. (2004) · Harvard Review of Psychiatry · doi:10.1080/10673220490910844 · Cited by 546 · see citing works
GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake
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Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study
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Pharmacology and behavioral pharmacology of the mesocortical dopamine system
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Lust, attraction, and attachment in mammalian reproduction
Fisher, H. E. (1998) · Human Nature · doi:10.1007/s12110-998-1010-5 · Cited by 429 · see citing works
The neurocircuitry of addiction: an overview
Feltenstein, M. W., & See, R. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.51 · Cited by 421 · see citing works
Romantic love: a mammalian brain system for mate choice
Fisher, H. E., Aron, A., & Brown, L. L. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1938 · Cited by 411 · see citing works
Romantic love: an fMRI study of a neural mechanism for mate choice.
Fisher, H., Aron, A., & Brown, L. L. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20772 · Cited by 396 · see citing works
Basal ganglia orient eyes to reward
Hikosaka, O., Nakamura, K., & Nakahara, H. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00458.2005 · Cited by 377 · see citing works
Ontogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents
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A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles
Aragona, B. J., Liu, Y., Curtis, J. T., Stephan, F. K., & Wang, Z. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03483.2003 · Cited by 351 · see citing works
Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location
Ford, C. P., Mark, G. P., & Williams, J. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4331-05.2006 · Cited by 339 · see citing works
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
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Defining the Brain Systems of Lust, Romantic Attraction, and Attachment
Fisher, H. E., Aron, A., Mashek, D., Li, H., & Brown, L. L. (2002) · Archives of Sexual Behavior · doi:10.1023/a:1019888024255 · Cited by 317 · see citing works
Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness
Fettes, P., Schulze, L., & Downar, J. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00025 · Cited by 299 · see citing works
Neurobiological mechanisms of anhedonia
Gorwood, P. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.3/pgorwood · Cited by 285 · see citing works
New developments in brain research of internet and gaming disorder
Weinstein, A., Livny, A., & Weizman, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.040 · Cited by 257 · see citing works
The role of the brain reward system in depression
Naranjo, C. A., Tremblay, L. K., & Busto, U. E. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00156-7 · Cited by 245 · see citing works
Dopamine genes and reward dependence in adolescents with excessive Internet video game play
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Sleep restriction increases the neuronal response to unhealthy food in normal-weight individuals
St-Onge, M.-P., Wolfe, S., Sy, M., Shechter, A., & Hirsch, J. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.114 · Cited by 229 · see citing works
Improving translation of animal models of addiction and relapse by reverse translation
Venniro, M., Banks, M. L., Heilig, M., Epstein, D. H., & Shaham, Y. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0378-z · Cited by 212 · see citing works
Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence
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Stress in adolescence and drugs of abuse in rodent models: role of dopamine, CRF, and HPA axis
Burke, A. R., & Miczek, K. A. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3369-1 · Cited by 207 · see citing works
Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area
Olson, V. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0345-05.2005 · Cited by 186 · see citing works
Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors
Andrews, M. M., Meda, S. A., Thomas, A. D., Potenza, M. N., Krystal, J. H., Worhunsky, P., Stevens, M. C., O'Malley, S., Book, G. A., Reynolds, B., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.049 · Cited by 181 · see citing works
Brain stimulation in the study and treatment of addiction
Feil, J., & Zangen, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.006 · Cited by 181 · see citing works
Restraint increases dopaminergic burst firing in awake rats
Anstrom, K. K., & Woodward, D. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300730 · Cited by 181 · see citing works
ΔFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment
Perrotti, L. I., Bolaños, C. A., Choi, K., Russo, S. J., Edwards, S., Ulery, P. G., Wallace, D. L., Self, D. W., Nestler, E. J., & Barrot, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04110.x · Cited by 178 · see citing works
Brain activity and desire for Internet video game play
Han, D. H., Bolo, N., Daniels, M. A., Arenella, L., Lyoo, I. K., & Renshaw, P. F. (2011) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2010.04.004 · Cited by 164 · see citing works
Co-occurrence of alcohol use disorder and behavioral addictions: relevance of impulsivity and craving
Di Nicola, M., Tedeschi, D., De Risio, L., Pettorruso, M., Martinotti, G., Ruggeri, F., Swierkosz-Lenart, K., Guglielmo, R., Callea, A., Ruggeri, G., et al. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.12.028 · Cited by 143 · see citing works
Drugs of abuse and stress impair LTP at inhibitory synapses in the ventral tegmental area
Niehaus, J. L., Murali, M., & Kauer, J. A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07256.x · Cited by 140 · see citing works
Rewarding and psychomotor stimulant effects of endomorphin-1: anteroposterior differences within the ventral tegmental area and lack of effect in nucleus accumbens
Zangen, A., Ikemoto, S., Zadina, J. E., & Wise, R. A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07225.2002 · Cited by 138 · see citing works
Reduced dopamine d1 receptor binding in the ventral striatum of cigarette smokers
Dagher, A., Bleicher, C., Aston, J. A. D., Gunn, R. N., Clarke, P. B. S., & Cumming, P. (2001) · Synapse · doi:10.1002/syn.1098 · Cited by 132 · see citing works
The HR/LR model: further evidence as an animal model of sensation seeking
Blanchard, M. M., Mendelsohn, D., & Stamp, J. A. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.05.009 · Cited by 121 · see citing works
The Orbitofrontal Cortex, Impulsivity, and Addiction: Probing Orbitofrontal Dysfunction at the Neural, Neurochemical, and Molecular Level
WINSTANLEY, C. A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1401.024 · Cited by 119 · see citing works
History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine
Oswald, L. M., Wand, G. S., Kuwabara, H., Wong, D. F., Zhu, S., & Brasic, J. R. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3407-z · Cited by 114 · see citing works
The neural basis of unconditional love
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Bupropion Treatment for Cocaine Abuse and Adult Attention-Deficit/Hyperactivity Disorder
Levin, F. R., Evans, S. M., McDowell, D. M., Brooks, D. J., & Nunes, E. (2002) · Journal of Addictive Diseases · doi:10.1300/j069v21n02_01 · Cited by 102 · see citing works
A double-blind placebo-controlled experimental study of nicotine: II—Effects on response inhibition and executive functioning
Dawkins, L., Powell, J. H., West, R., Powell, J., & Pickering, A. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0634-6 · Cited by 85 · see citing works
Repeated Lofexidine Treatment Attenuates Stress-Induced, But not Drug Cues-Induced Reinstatement of a Heroin-Cocaine Mixture (Speedball) Seeking in Rats
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A neurobehavioral approach to addiction: implications for the opioid epidemic and the psychology of addiction
Bechara, A., Berridge, K. C., Bickel, W. K., Morón, J. A., Williams, S. B., & Stein, J. S. (2019) · Psychological Science in the Public Interest · doi:10.1177/1529100619860513 · Cited by 82 · see citing works
Stress-induced Relapse to Drug Seeking in the Rat; Role of the Bed Nucleus of the Stria Terminalis and Amygdala
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Phospholipase Cγ in Distinct Regions of the Ventral Tegmental Area Differentially Modulates Mood-Related Behaviors
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Functions of the dopaminergic innervation of the nucleus accumbens.
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Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment
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Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task
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Electrical stimulation of the medial forebrain bundle in pre-clinical studies of psychiatric disorders
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Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats
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Early adolescent nicotine exposure affects later-life cocaine reward in mice
Alajaji, M., Lazenka, M. F., Kota, D., Wise, L. E., Younis, R. M., Carroll, F. I., Levine, A., Selley, D. E., Sim-Selley, L. J., & Damaj, M. I. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.01.032 · Cited by 39 · see citing works
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Yohimbine-Induced Amygdala Activation in Pathological Gamblers: A Pilot Study
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Authors: Wise, R. A.
Affiliations: Concordia University (CA)
Corresponding author: Wise, Roy A
ORCID: Wise, Roy A
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 1996-04
Volume: 6
Issue: 2
Pages: 243-251
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/s0959-4388(96)80079-1
OpenAlex: W2071280486
Cited by: 1,072
References: 99
Citations by year: 2026: 7 · 2025: 4 · 2024: 2 · 2023: 10 · 2022: 8 · 2021: 15 · 2020: 66 · 2019: 18 · 2018: 14 · 2017: 20 · 2016: 27 · 2015: 36 · 2014: 38 · 2013: 42 · 2012: 63
FWCI: 2.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: addiction, reward systems, trigger zones, heroin, cocaine, nicotine, alcohol, phencyclidine, cannabis, withdrawal symptoms
MeSH terms: Animals, Brain, Humans, Neural Pathways, Pharmacology, Reward, Second Messenger Systems, Substance-Related Disorders

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