The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Chromosomal Basis of Human Neoplasia
Abstract
High-resolution banding techniques for the study of human chromosomes have revealed that the malignant cells of most tumors analyzed have characteristic chromosomal defects. Translocations of the same chromosome segments with precise breakpoints occur in many leukemias and lymphomas, and a specific chromosome band is deleted in several carcinomas. Trisomy, or the occurrence of a particular chromosome in triplicate, is the only abnormality observed in a few neoplasias. It is proposed that chromosomal rearrangements play a central role in human neoplasia and may exert their effects through related genomic mechanisms. Thus, a translocation could serve to place an oncogene next to an activating DNA sequence, a deletion to eliminate an oncogene repressor, and trisomy to carry extra gene dosage.
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Cites
ROWLEY, J. D. (1973) · Nature · doi:10.1038/243290a0 · Cited by 4,291
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
Klein, A. D., Kessel, A. G. V., Grosveld, G., Bartram, C. R., Hagemeijer, A., Bootsma, D., Spurr, N. K., Heisterkamp, N., Groffen, J., & Stephenson, J. R. (1982) · Nature · doi:10.1038/300765a0 · Cited by 1,378
Cited by
G 1 Events and Regulation of Cell Proliferation
Pardee, A. B. (1989) · Science · doi:10.1126/science.2683075 · Cited by 2,182
Purification of DNA from formaldehyde fixed and paraffin embedded human tissue
Goelz, S. E., Hamilton, S. R., & Vogelstein, B. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)90390-0 · Cited by 803
Coquelle, A., Pipiras, E., Toledo, F., Buttin, G., & Debatisse, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80201-9 · Cited by 391
BCL2 translocation frequency rises with age in humans
Liu, Y., Hernandez, A. M., Shibata, D., & Cortopassi, G. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8910 · Cited by 358
Role of Free Radicals in Aging and Disease
HARMAN, D. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb27444.x · Cited by 262
Metadata
- Authors
- Yunis, J. J.
- Venue
- Science
- Published
- 1983-07-15
- Volume
- 221
- Issue
- 4607
- Pages
- 227-236
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092299362
- Cited by
- 1,087
- References
- 2
- FWCI
- 98.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yunis, J. J. (1983). The Chromosomal Basis of Human Neoplasia. Science. https://doi.org/10.1126/science.6336310
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
