The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Expression of Cellular Oncogenes in Human Malignancies
Abstract
Cellular oncogenes have been implicated in the induction of malignant transformation in some model systems in vitro and may be related to malignancies in vivo in some vertebrate species. This article describes a study of the expression of 15 cellular oncogenes in fresh human tumors from 54 patients, representing 20 different tumor types. More than one cellular oncogene was transcriptionally active in all of the tumors examined. In 14 patients it was possible to study normal and malignant tissue from the same organ. In many of these patients, the transcriptional activity of certain oncogenes was greater in the malignant than the normal tissue. The cellular fes (feline sarcoma) oncogene, not previously known to be transcribed in mammalian tissue, was found to be active in lung and hematopoietic malignancies.
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Citations
Cites
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Mechanism of activation of a human oncogene
Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
STEHELIN, D., VARMUS, H. E., BISHOP, J. M., & VOGT, P. K. (1976) · Nature · doi:10.1038/260170a0 · Cited by 1,321
Cited by
Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987) · Science · doi:10.1126/science.3798106 · Cited by 11,760
Self-citationSherr, C. J., Rettenmier, C. W., Sacca, R., Roussel, M. F., Look, A. T., & Stanley, E. R. (1985) · Cell · doi:10.1016/s0092-8674(85)80047-7 · Cited by 1,540
Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins
Bar-Sagi, D., & Feramisco, J. R. (1986) · Science · doi:10.1126/science.3090687 · Cited by 734
Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis
Hoffman, R. M. (1984) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(84)90019-2 · Cited by 349
Activation of pp60c-src protein kinase activity in human colon carcinoma.
Bolen, J. B., Veillette, A., Schwartz, A. M., DeSeau, V, & Rosen, N. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2251 · Cited by 299
Metadata
- Authors
- Slamon, D. J., deKernion, J. B., Verma, I. M., & Cline, M. J.
- Venue
- Science
- Published
- 1984-04-20
- Volume
- 224
- Issue
- 4646
- Pages
- 256-262
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2063837791
- Cited by
- 827
- References
- 3
- FWCI
- 60.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Slamon, D. J., deKernion, J. B., Verma, I. M., & Cline, M. J. (1984). Expression of Cellular Oncogenes in Human Malignancies. Science. https://doi.org/10.1126/science.6538699
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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