Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

Bar-Sagi, Dafna; Feramisco, James R.

doi:10.1126/science.3090687

Cited by 735Protein Kinase Regulation and GTPase SignalingCellular transport and secretionCellular Mechanics and Interactions

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

Bar-Sagi, Dafna, Feramisco, James R.·1986·Science

DOI 10.1126/science.3090687

Open this paper in CoChat — free account

Abstract

Expression of the ras oncogene is thought to be one of the contributing events in the initiation of certain types of human cancer. To determine the cellular activities that are directly triggered by ras proteins, the early consequences of microinjection of the human H- ras proteins into quiescent rat embryo fibroblasts were investigated. Within 30 minutes to 1 hour after injection, cells show a marked increase in surface ruffles and fluid-phase pinocytosis. The rapid enhancement of membrane ruffling and pinocytosis is induced by both the proto-oncogenic and the oncogenic forms of the H- ras protein. The effects produced by the oncogenic protein persist for more than 15 hours after injection, whereas the effects of the proto-oncogenic protein are short-lived, being restricted to a 3-hour interval after injection. The stimulatory effect of the ras oncogene protein on ruffling and pinocytosis is dependent on the amount of injected protein and is accompanied by an apparent stimulation of phospholipase A 2 activity. These rapid changes in cell membrane activities induced by ras proteins may represent primary events in the mechanism of action of ras proteins.

Integrity signals

Registry

Crossref · 10.1126/science.3090687

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The ability to stimulate macropinocytosis is a distinctive feature of KRAS* activation.
“The ability to stimulate macropinocytosis, a regulated form of endocytosis, is a distinctive feature of KRAS∗ activation,13 and PDAC cells harboring KRAS∗ rely on increased levels of macropinocytosis for nutrient salvaging to sustain uncontrolled cell growth.14”
From Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers (2025) · cites this paper as [13]
The autophagy-MHC-I relationship provides mechanistic insight into functional genomics studies that link autophagy and immune evasion in PDAC.
“The autophagy-MHC-I relationship provides mechanistic insight to functional genomics studies in mice, which have also linked autophagy and immune evasion in PDAC228.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [228]

Inositol trisphosphate and diacylglycerol as second messengers
Berridge, M. J. (1984) · Biochemical Journal · doi:10.1042/bj2200345 · Cited by 3,531 · see citing works
G proteins and dual control of adenylate cyclase
Gilman, A. G. (1984) · Cell · doi:10.1016/0092-8674(84)90336-2 · Cited by 1,812 · see citing works
Mechanism of activation of a human oncogene
Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393 · see citing works
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene
Reddy, E. P., Reynolds, R. K., Santos, E., & Barbacid, M. (1982) · Nature · doi:10.1038/300149a0 · Cited by 1,391 · see citing works
Intracellular phospholipases A
van den BOSCH, H. (1980) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(80)90574-x · Cited by 982 · see citing works
Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene
Parada, L. F., Tabin, C. J., Shih, C., & Weinberg, R. A. (1982) · Nature · doi:10.1038/297474a0 · Cited by 947 · see citing works
Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells
Mulcahy, L. S., Smith, M. R., & Stacey, D. W. (1985) · Nature · doi:10.1038/313241a0 · Cited by 842 · see citing works
Expression of Cellular Oncogenes in Human Malignancies
Slamon, D. J., deKernion, J. B., Verma, I. M., & Cline, M. J. (1984) · Science · doi:10.1126/science.6538699 · Cited by 826 · see citing works
Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats
Zarbl, H., Sukumar, S. V., Arthur, A. V., Martı́n-Zanca, D., & Barbacid, M. (1985) · Nature · doi:10.1038/315382a0 · Cited by 806 · see citing works
Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.
Der, C. J., Krontiris, T. G., & Cooper, G. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.11.3637 · Cited by 785 · see citing works
Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation
Bar‐Sagi, D., & Feramisco, J. R. (1985) · Cell · doi:10.1016/0092-8674(85)90280-6 · Cited by 733 · see citing works
Self-citation
Comparative biochemical properties of normal and activated human ras p21 protein
McGrath, J. P., Capon, D. J., Goeddel, D. V., & Levinson, A. D. (1984) · Nature · doi:10.1038/310644a0 · Cited by 699 · see citing works
Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus
Chang, E. H., Furth, M. E., Scolnick, E. M., & Lowy, D. R. (1982) · Nature · doi:10.1038/297479a0 · Cited by 588 · see citing works
The p21 ras C-terminus is required for transformation and membrane association
Willumsen, B. M., Christensen, A., Hubbert, N. L., Papageorge, A. G., & Lowy, D. R. (1984) · Nature · doi:10.1038/310583a0 · Cited by 584 · see citing works
Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.
Gibbs, W. W., Sigal, I. S., Poe, M., & Scolnick, E. M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.18.5704 · Cited by 580 · see citing works
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations
Capon, D. J., Seeburg, P. H., McGrath, J. P., Hayflick, J. S., Edman, U., Levinson, A. D., & Goeddel, D. V. (1983) · Nature · doi:10.1038/304507a0 · Cited by 551 · see citing works
The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity
Sweet, R. W., Yokoyama, S., Kamata, T., Feramisco, J. R., Rosenberg, M. J., & Gross, M. S. (1984) · Nature · doi:10.1038/311273a0 · Cited by 532 · see citing works
Self-citation
Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.
Nakamura, T., & Ui, M. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83662-1 · Cited by 507 · see citing works
The concept of lipid domains in membranes.
Karnovsky, M. J., Kleinfeld, A. M., Hoover, R. L., & Klausner, R. D. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.94.1.1 · Cited by 470 · see citing works
Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line
Noda, M., Ko, M. S. H., Ogura, A., Liu, D. G., Amano, T., Takano, T., & Ikawa, Y. (1985) · Nature · doi:10.1038/318073a0 · Cited by 449 · see citing works
Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites
Fleischman, L. F., Chahwala, S. B., & Cantley, L. C. (1986) · Science · doi:10.1126/science.3001936 · Cited by 422 · see citing works
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin
Bokoch, G., & Gilman, A. G. (1984) · Cell · doi:10.1016/0092-8674(84)90008-4 · Cited by 422 · see citing works
Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21
Hagag, N. G., Halegoua, S., & Viola, M. V. (1986) · Nature · doi:10.1038/319680a0 · Cited by 419 · see citing works
Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry
Willingham, M. C., Pastan, I. H., Shih, T. Y., & Scolnick, E. M. (1980) · Cell · doi:10.1016/0092-8674(80)90091-4 · Cited by 398 · see citing works
Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.
Moolenaar, W. H., Tertoolen, L. G. J., & de Laat, S. W. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39690-4 · Cited by 392 · see citing works
Three human transforming genes are related to the viral ras oncogenes.
Shimizu, K., Goldfarb, M. P., Suard, Y. M. L., Perucho, M., Li, Y., Kamata, T., Feramisco, J. R., Stavnezer, E., Fogh, J. M., & Wigler, M. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.8.2112 · Cited by 389 · see citing works
Self-citation
Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells
Feramisco, J. R., Gross, M. S., Kamata, T., Rosenberg, M. J., & Sweet, R. W. (1984) · Cell · doi:10.1016/0092-8674(84)90531-2 · Cited by 389 · see citing works
Self-citation
PINOCYTOSIS IN FIBROBLASTS
Steinman, R. M., Silver, J., & Cohn, Z. A. (1974) · The Journal of Cell Biology · doi:10.1083/jcb.63.3.949 · Cited by 389 · see citing works
Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein
Stacey, D. W., & Kung, H. (1984) · Nature · doi:10.1038/310508a0 · Cited by 380 · see citing works
The Biosynthesis and Metabolism of Prostaglandins
Lands, W. E. M. (1979) · Annual Review of Physiology · doi:10.1146/annurev.ph.41.030179.003221 · Cited by 375 · see citing works
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1
Shimizu, K., Birnbaum, D., Ruley, M. A., Fasano, O., Suard, Y. M. L., Edlund, L., Taparowsky, E. J., Goldfarb, M. P., & Wigler, M. H. (1983) · Nature · doi:10.1038/304497a0 · Cited by 373 · see citing works
STUDIES ON THE MECHANISM OF ACTION OF A NEW Ca2+ ANTAGONIST, 8‐(N,N‐DIETHYLAMINO)OCTYL 3,4,5‐TRIMETHOXYBENZOATE HYDROCHLORIDE IN SMOOTH AND SKELETAL MUSCLES
Chiou, C. Y., & Malagodi, M. H. (1975) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1975.tb07359.x · Cited by 346 · see citing works
Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor.
Haigler, H. T., McKanna, J. A., & Cohen, S. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.83.1.82 · Cited by 330 · see citing works
Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses
Scolnick, E. M., Papageorge, A. G., & Shih, T. Y. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.10.5355 · Cited by 316 · see citing works
Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors.
Chinkers, M., McKanna, J. A., & Cohen, S. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.83.1.260 · Cited by 296 · see citing works
Formation of lysophosphatidylcholine by human platelets in response to thrombin. Support for the phospholipase A2 pathway for the liberation of arachidonic acid.
McKean, M. L., Smith, J. B., & Silver, M. J. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69832-7 · Cited by 217 · see citing works
Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins
Kamata, T., & Feramisco, J. R. (1984) · Nature · doi:10.1038/310147a0 · Cited by 194 · see citing works
Self-citation
Transfection of v- ras H DNA into MCF-7 Human Breast Cancer Cells Bypasses Dependence on Estrogen for Tumorigenicity
Kasid, A., Lippman, M. E., Papageorge, A. G., Lowy, D. R., & Gelmann, E. P. (1985) · Science · doi:10.1126/science.4039465 · Cited by 185 · see citing works
Surface functions during mitosis I: Phagocytosis, pinocytosis and mobility of surface-bound ConA
Berlin, R. D., Oliver, J. M., & Walter, R. J. (1978) · Cell · doi:10.1016/0092-8674(78)90002-8 · Cited by 184 · see citing works
Stimulus response coupling in the human neutrophil. I. Kinetic analysis of changes in calcium permeability.
Korchak, H. M., Rutherford, L. E., & Weissmann, G. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43010-9 · Cited by 174 · see citing works
Mediation of pinocytosis in cultured arterial smooth muscle and endothelial cells by platelet-derived growth factor
Davies, P., & Ross, R. (1978) · The Journal of Cell Biology · doi:10.1083/jcb.79.3.663 · Cited by 173 · see citing works
Influence of epidermal growth factor (EGF) on ruffling activity, pinocytosis and proliferation of cultivated human glia cells
Brunk, U. T., Schellens, J. H. M., & Westermark, B. (1976) · Experimental Cell Research · doi:10.1016/0014-4827(76)90266-4 · Cited by 166 · see citing works
The role of calcium in lymphocyte proliferation. (An interpretive review)
Lichtman, A., Segel, G., & Lichtman, M. A. (1983) · Blood · doi:10.1182/blood.v61.3.413.413 · Cited by 151 · see citing works
Rapid, sequential changes in surface morphology of PC12 pheochromocytoma cells in response to nerve growth factor
Connolly, J., Greene, L., Viscarello, R. R., & Riley, W. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.82.3.820 · Cited by 144 · see citing works
Ras p21 proteins with high or low GTPase activity can efficiently transform NIH3T3 cells
Lacal, J. C., Srivastava, S. K., Anderson, P. S., & Aaronson, S. A. (1986) · Cell · doi:10.1016/0092-8674(86)90270-9 · Cited by 111 · see citing works
The dependence on Ca2+ of phosphatidylinositol breakdown and enzyme secretion in rabbit neutrophils stimulated by formylmethionyl-leucylphenylalanine or ionomycin
Cockcroft, S., Bennett, J. P., & Gomperts, B. D. (1981) · Biochemical Journal · doi:10.1042/bj2000501 · Cited by 110 · see citing works
Purification and Characterization of Human H-ras Proteins Expressed in Escherichia coli
Gross, M. S., Sweet, R. W., Sathe, G. M., Yokoyama, S., Fasano, O., Goldfarb, M. P., Wigler, M. H., & Rosenberg, M. J. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.5.1015-1024.1985 · Cited by 105 · see citing works
[48] Fluorescent localization of contractile proteins in tissue culture cells
Wang, K., Feramisco, J. R., & Ash, J. F. (1982) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(82)85050-7 · Cited by 95 · see citing works
Self-citation
Role of stimulation of arachidonic acid release in the proliferative response of 3T3 mouse fibroblasts to platelet‐derived growth factor
Shier, W. T., & Durkin, J. P. (1982) · Journal of Cellular Physiology · doi:10.1002/jcp.1041120204 · Cited by 91 · see citing works
Insulin-induced formation of ruffling membranes of KB cells and its correlation with enhancement of amino acid transport.
Goshima, K., Masuda, A., & Owaribe, K. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.98.3.801 · Cited by 87 · see citing works
Membrane activity and topography of F-Met-Leu-Phe-Treated polymorphonuclear leukocytes. Acute and sustained responses to chemotactic peptide.
Davis, B. H., Walter, R. J., Pearson, C. B., Becker, E. L., & Oliver, J. M. (1982) · PubMed Central · Cited by 80 · see citing works
Efflux of 45CA2+ from human fibroblasts in response to serum or growth factors
Owen, N. E., & Villereal, M. L. (1983) · Journal of Cellular Physiology · doi:10.1002/jcp.1041170105 · Cited by 66 · see citing works
[33] Use of horseradish peroxidase and fluorescent dextrans to study fluid pinocytosis in leukocytes
Oliver, J. M., Berlin, R. D., & Davis, B. H. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)08100-3 · Cited by 52 · see citing works
Biochemical characterization of polypeptides encoded by mutated human Ha-ras1 genes.
Colby, W. W., Hayflick, J. S., Clark, S. G., & Levinson, A. D. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.2.730 · Cited by 42 · see citing works
Evidence for a role of phospholipase activity in the serum stimulation of Na+ influx in human fibroblasts.
Vicentini, L. M., Miller, R. J., & Villereal, M. L. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39814-9 · Cited by 36 · see citing works
Reversible pinocytosis in polymorphonuclear leukocytes.
Daukas, G., Lauffenburger, D. A., & Zigmond, S. H. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.6.1642 · Cited by 34 · see citing works
Surface functions during mitosis in rat basophilic leukemia cells.
Oliver, J. M., Seagrave, J., Pfeiffer, J. R., Feibig, M. L., & Deanin, G. G. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.6.2156 · Cited by 31 · see citing works
Membrane economics in endocytic systems
Duncan, R., & Pratten, M. K. (1977) · Journal of Theoretical Biology · doi:10.1016/0022-5193(77)90241-7 · Cited by 31 · see citing works
Heparin-treated, v-myc-transformed chicken heart mesenchymal cells assume a normal morphology but are hypersensitive to epidermal growth factor (EGF) and brain fibroblast growth factor (bFGF); cells transformed by the v-Ha-ras oncogene are refractory to EGF and bFGF but are hypersensitive to insulin-like growth factors.
Balk, S. D., Riley, T. M., Gunther, H. S., & Morisi, A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.17.5781 · Cited by 30 · see citing works
The stoichiometry of the Ca2+ pump in human erythrocyte vesicles: Modulation by Ca2+, Mg2+ and calmodulin
Akyempon, C. K., & Roufogalis, B. D. (1982) · Cell Calcium · doi:10.1016/0143-4160(82)90034-3 · Cited by 15 · see citing works

Flagged first, then by citations

Sorted by citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., & Hall, A. (1992) · Cell · doi:10.1016/0092-8674(92)90164-8 · Cited by 3,651 · see citing works
Small GTP-Binding Proteins
Takai, Y., Sasaki, T., & Matozaki, T. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.153 · Cited by 2,481 · see citing works
Role of platelet-derived growth factors in physiology and medicinePreprint
Andræ, J., Gallini, R., & Betsholtz, C. (2008) · Genes & Development · doi:10.1101/gad.1653708 · Cited by 2,444 · see citing works
From Krebs to clinic: glutamine metabolism to cancer therapy
Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119 · see citing works
Drugging the undruggable RAS: Mission Possible?
Cox, A. D., Fesik, S. W., Kimmelman, A. C., Luo, J., & Der, C. J. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4389 · Cited by 1,997 · see citing works
Rho and Rac Take Center Stage
Burridge, K., & Wennerberg, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00003-0 · Cited by 1,790 · see citing works
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., et al. (2013) · Nature · doi:10.1038/nature12138 · Cited by 1,683 · see citing works
Self-citation
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
Lowenstein, E. J., Daly, R. J., Batzer, A., Li, W., Margolis, B. L., Lammers, R., Ullrich, A., Skolnik, E. Y., Bar‐Sagi, D., & Schlessinger, J. (1992) · Cell · doi:10.1016/0092-8674(92)90167-b · Cited by 1,632 · see citing works
Self-citation
Genetics and biology of pancreatic ductal adenocarcinomaPreprint
Hezel, A. F., Kimmelman, A. C., Stanger, B. Z., Bardeesy, N. M., & DePinho, R. A. (2006) · Genes & Development · doi:10.1101/gad.1415606 · Cited by 1,570 · see citing works
Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
Minden, A., Lin, A., Claret, F.-X., Abo, A., & Karin, M. (1995) · Cell · doi:10.1016/s0092-8674(05)80019-4 · Cited by 1,481 · see citing works
Ras oncogenes: split personalities
Karnoub, A. E., & Weinberg, R. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2438 · Cited by 1,467 · see citing works
The hallmarks of cancer metabolism: still emerging
Pavlova, N. N., Zhu, J., & Thompson, C. B. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.01.007 · Cited by 1,418 · see citing works
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
Bucci, C., Parton, R. G., Mather, I. H., Stunnenberg, H. G., Simons, K., Hoflack, B., & Zerial, M. (1992) · Cell · doi:10.1016/0092-8674(92)90306-w · Cited by 1,370 · see citing works
Pancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works
Metabolic regulation of cell growth and proliferation
Zhu, J., & Thompson, C. B. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0123-5 · Cited by 1,106 · see citing works
Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras
Rodriguez‐Viciana, P., Warne, P. H., Khwaja, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M. D., Ridley, A. J., & Downward, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80226-3 · Cited by 1,063 · see citing works
The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts
Kozma, R., Ahmed, S., Best, A., & Lim, L. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.1942 · Cited by 1,021 · see citing works
Shaping cups into phagosomes and macropinosomes
Swanson, J. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2447 · Cited by 941 · see citing works
A ras-like protein is required for a post-Golgi event in yeast secretion
Salminen, A., & Novick, P. (1987) · Cell · doi:10.1016/0092-8674(87)90455-7 · Cited by 897 · see citing works
Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein
Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka, E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2211 · Cited by 893 · see citing works
Self-citation
KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer
Waters, A. M., & Der, C. J. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031435 · Cited by 875 · see citing works
Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton
Hall, A. (1994) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.10.110194.000335 · Cited by 823 · see citing works
Virus entry by macropinocytosis
Mercer, J., & Helenius, A. (2009) · Nature Cell Biology · doi:10.1038/ncb0509-510 · Cited by 814 · see citing works
S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells
Hardt, W., Chen, L., Schuebel, K. E., Bustelo, X. R., & Galán, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81442-7 · Cited by 811 · see citing works
Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP
Feig, L. A., & Cooper, G. M. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3235-3243.1988 · Cited by 799 · see citing works
Cytoskeleton—Plasma Membrane Interactions
Luna, E. J., & Hitt, A. L. (1992) · Science · doi:10.1126/science.1439807 · Cited by 786 · see citing works
Signal transduction via platelet-derived growth factor receptors
Heldin, C., Östman, A., & Rönnstrand, L. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(98)00015-8 · Cited by 740 · see citing works
Macropinocytosis
Swanson, J. A., & Watts, C. K. W. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)89101-1 · Cited by 735 · see citing works
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
Kamphorst, J. J., Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., & Rabinowitz, J. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307237110 · Cited by 726 · see citing works
Macropinocytosis: an endocytic pathway for internalising large gulps
Lim, J. P., & Gleeson, P. A. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.20 · Cited by 716 · see citing works
Defining Macropinocytosis
Kerr, M. C., & Teasdale, R. D. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00878.x · Cited by 685 · see citing works
The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery
Segev, N., Mulholland, J., & Botstein, D. (1988) · Cell · doi:10.1016/0092-8674(88)90433-3 · Cited by 689 · see citing works
KRAS: feeding pancreatic cancer proliferation
Bryant, K. L., Mancias, J. D., Kimmelman, A. C., & Der, C. J. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.12.004 · Cited by 675 · see citing works
Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine
Zhang, J., Pavlova, N. N., & Thompson, C. B. (2017) · The EMBO Journal · doi:10.15252/embj.201696151 · Cited by 651 · see citing works
A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast
Goud, B., Salminen, A., Walworth, N. C., & Novick, P. (1988) · Cell · doi:10.1016/0092-8674(88)90093-1 · Cited by 585 · see citing works
Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.
Lavoie, J. N., Hickey, E. D., Weber, L. A., & Landry, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80512-2 · Cited by 542 · see citing works
Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells
Ridley, A. J., Comoglio, P. M., & Hall, A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.1110 · Cited by 535 · see citing works
Genetics and biology of pancreatic ductal adenocarcinoma
Ying, H., Dey, P., Yao, W., Kimmelman, A. C., Draetta, G. F., Maitra, A., & DePinho, R. A. (2016) · Genes & Development · doi:10.1101/gad.275776.115 · Cited by 527 · see citing works
New aspects of amino acid metabolism in cancer
Vettore, L. A., Westbrook, R. L., & Tennant, D. A. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0620-5 · Cited by 503 · see citing works
Lipocortin and the mechanism of action of the glucocorticoids
Flower, R. J. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb11614.x · Cited by 494 · see citing works
mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient
Wyant, G., Abu-Remaileh, M., Wolfson, R. L., Chen, W. W., Freinkman, E., Danai, L. V., Heiden, M. V. V., & Sabatini, D. (2017) · Cell · doi:10.1016/j.cell.2017.09.046 · Cited by 434 · see citing works
The utilization of extracellular proteins as nutrients is suppressed by mTORC1
Palm, W., Park, Y., Wright, K., Pavlova, N. N., Tuveson, D. A., & Thompson, C. B. (2015) · Cell · doi:10.1016/j.cell.2015.06.017 · Cited by 457 · see citing works
rac, a novel ras-related family of proteins that are botulinum toxin substrates
Didsbury, J., Weber, R. F., Bokoch, G. M., Evans, T., & Snyderman, R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84716-6 · Cited by 575 · see citing works
Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells [published erratum appears in J Cell Biol 1990 Mar;110(3):859]
West, M. A. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.6.2731 · Cited by 451 · see citing works
Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria
Francis, C. L., Ryan, T. A., Jones, B. D., Smith, S. J., & Falkow, S. (1993) · Nature · doi:10.1038/364639a0 · Cited by 446 · see citing works
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.Preprint
Bruder, J. T., Heidecker, G., & Rapp, U. R. (1992) · Genes & Development · doi:10.1101/gad.6.4.545 · Cited by 444 · see citing works
Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
Fan, J., Kamphorst, J. J., Mathew, R., Chung, M. K., White, E., Shlomi, T., & Rabinowitz, J. D. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.65 · Cited by 428 · see citing works
Signaling to Rho GTPases
Kjøller, L., & Hall, A. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4674 · Cited by 405 · see citing works
Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer
Halbrook, C. J., & Lyssiotis, C. A. (2017) · Cancer Cell · doi:10.1016/j.ccell.2016.12.006 · Cited by 394 · see citing works
Endocytosis and CancerPreprint
Mellman, I., & Yarden, Y. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016949 · Cited by 391 · see citing works
NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer
Chio, I. I. C., Jafarnejad, S. M., Ponz-Sarvise, M., Park, Y., Rivera, K., Palm, W., Wilson, J., Sangar, V., Hao, Y., Öhlund, D., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.056 · Cited by 378 · see citing works
“, 2015), as in the case of Krasmutant cells (Bar-Sagi and Feramisco, 1986).”
Nutrient acquisition strategies of mammalian cells
Palm, W., & Thompson, C. B. (2017) · Nature · doi:10.1038/nature22379 · Cited by 388 · see citing works
A New Paradigm for Aptamer Therapeutic AS1411 Action: Uptake by Macropinocytosis and Its Stimulation by a Nucleolin-Dependent Mechanism
Reyes‐Reyes, E. M., Teng, Y., & Bates, P. J. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0920 · Cited by 389 · see citing works
The coated pit and macropinocytic pathways serve distinct endosome populations
Hewlett, L. J., Prescott, A., & Watts, C. K. W. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.5.689 · Cited by 380 · see citing works
Calcium-dependent phospholipid- (and membrane-) binding proteins
Klee, C. B. (1988) · Biochemistry · doi:10.1021/bi00418a001 · Cited by 374 · see citing works
Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS
Joneson, T., White, M. A., Wigler, M. H., & Bar‐Sagi, D. (1996) · Science · doi:10.1126/science.271.5250.810 · Cited by 371 · see citing works
Self-citation
A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion
Nobes, C. D., Lauritzen, I., Mattéi, M., Paris, S., Hall, A., & Chardin, P. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.1.187 · Cited by 358 · see citing works
Involvement of phosphoinositide 3‐kinase in insulin‐ or IGF‐1‐induced membrane ruffling.
Kotani, K., Yonezawa, K., Hara, K., Ueda, H., Kitamura, Y., Sakaue, H., Ando, A., Chavanieu, A., Calas, B., & Grigorescu, F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06515.x · Cited by 356 · see citing works
Mammalian non-pancreatic phospholipases A2
Kudo, I., Murakami, M., Hara, S., & Inoue, K. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90003-r · Cited by 351 · see citing works
Signal transduction in the mammalian cell during bacterial attachment and entry
Bliska, J. B., Galán, J. E., & Falkow, S. (1993) · Cell · doi:10.1016/0092-8674(93)90270-z · Cited by 346 · see citing works
Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation
Khosravi‐Far, R., White, M. A., Westwick, J. K., Solski, P. A., Chrzanowska‐Wodnicka, M., Aelst, L. V., Wigler, M. H., & Der, C. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3923 · Cited by 343 · see citing works
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
Lambert, J. M., Lambert, Q. T., Reuther, G. W., Malliri, A., Siderovski, D. P., Sondek, J., Collard, J. G., & Der, C. J. (2002) · Nature Cell Biology · doi:10.1038/ncb833 · Cited by 326 · see citing works
Targeted protein degradation: advances in drug discovery and clinical practice
Zhong, G., Chang, X., Xie, W., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02004-x · Cited by 326 · see citing works
Cellular ras activity and phospholipid metabolism
Yu, C. (1988) · Cell · doi:10.1016/0092-8674(88)90531-4 · Cited by 326 · see citing works
Dynamic fatty acylation of p21N‐ras.
Magee, A. I., Gutierrez-Gonzalez, L. A., McKay, I. A., Marshall, C. J., & Hall, A. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02656.x · Cited by 307 · see citing works
Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors
Gupta, A. K., & Curtis, A. S. G. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.09.095 · Cited by 302 · see citing works
Regulation of Phosphorylation Pathways by p21 GTPases
Lim, L., Manser, E. J., LEUNG, T. K. C., & Hall, C. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0171r.x · Cited by 302 · see citing works
Regulators and Effectors of ras Proteins
Bollag, G. E., & McCormick, F. P. (1991) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.07.110191.003125 · Cited by 302 · see citing works
Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases
Lanzetti, L., Palamidessi, A., Areces, L. B., Scita, G., & Fiore, P. P. D. (2004) · Nature · doi:10.1038/nature02542 · Cited by 300 · see citing works
Signal transduction from multiple Ras effectors
Katz, M. E., & McCormick, F. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80112-8 · Cited by 299 · see citing works
Regulation of Macropinocytosis by p21-activated Kinase-1
Dharmawardhane, S., Schürmann, A., Sells, M. A., Chernoff, J., Schmid, S. L., & Bokoch, G. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.10.3341 · Cited by 298 · see citing works
The endocytic activity of dendritic cells.
Steinman, R. M., & Swanson, J. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.2.283 · Cited by 297 · see citing works
Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition
Zondag, G. C. M., Evers, E. E., ten Klooster, J. P., Janssen, L., van der Kammen, R. A., & Collard, J. G. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.4.775 · Cited by 289 · see citing works
Rho GTPases in transformation and metastasis
Jaffe, A. B., & Hall, A. (2002) · Advances in cancer research · doi:10.1016/s0065-230x(02)84003-9 · Cited by 276 · see citing works
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas
Suwa, H., Ohshio, G., Imamura, T., Watanabe, G., Arii, S., Imamura, M., Narumiya, S., Hiai, H., & Fukumoto, M. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.23 · Cited by 275 · see citing works
Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes
Nakase, I., Kobayashi, N. B., Takatani‐Nakase, T., & Yoshida, T. (2015) · Scientific Reports · doi:10.1038/srep10300 · Cited by 271 · see citing works
The Extracellular Matrix and Pancreatic Cancer: A Complex Relationship
Weniger, M., Honselmann, K. C., & Liss, A. S. (2018) · Cancers · doi:10.3390/cancers10090316 · Cited by 271 · see citing works
Ras‐activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1
Tall, G. G., Barbieri, M. A., Stahl, P. D., & Horazdovsky, B. F. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00008-9 · Cited by 308 · see citing works
Contact with epithelial cells induces the formation of surface appendages on Salmonella typhimurium
Ginocchio, C. C., Olmsted, S. B., Wells, C. L., & Galán, J. E. (1994) · Cell · doi:10.1016/0092-8674(94)90510-x · Cited by 257 · see citing works
Methuosis
Maltese, W. A., & Overmeyer, J. H. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.02.028 · Cited by 254 · see citing works
Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells
Chi, S., Kitanaka, C., Noguchi, K., Mochizuki, T., Nagashima, Y., Shirouzu, M., Fujita, H., Yoshida, M., Chen, W., Asai, A., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202538 · Cited by 246 · see citing works
Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase.
Radhakrishna, H., Klausner, R. D., & Donaldson, J. G. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.4.935 · Cited by 239 · see citing works
Endocytosis in cancer and cancer therapy
Banushi, B., Joseph, S. R., Lum, B., Lee, J. J., & Simpson, F. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00574-6 · Cited by 245 · see citing works
Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer
Recouvreux, M. V., & Commisso, C. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00261 · Cited by 237 · see citing works
The Ways of Endocytosis
van Deurs, B., PETERSEN, O. W., Olsnes, S., & Sandvig, K. (1989) · International review of cytology · doi:10.1016/s0074-7696(08)61336-4 · Cited by 236 · see citing works
Constitutive Macropinocytosis in Oncogene-transformed Fibroblasts Depends on Sequential Permanent Activation of Phosphoinositide 3-Kinase and Phospholipase C
Amyere, M., Payrastre, B., Krause, U., Smissen, P. V. D., Veithen, A., & Courtoy, P. J. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.10.3453 · Cited by 233 · see citing works
Coxsackievirus Entry across Epithelial Tight Junctions Requires Occludin and the Small GTPases Rab34 and Rab5
Coyne, C. B., Shen, L., Turner, J. R., & Bergelson, J. M. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.07.003 · Cited by 232 · see citing works
Targeting Drug Chemo-Resistance in Cancer Using Natural Products
Talib, W. H., Alsayed, A. R., Barakat, M. M., Abu-Taha, M. I., & Mahmod, A. I. (2021) · Biomedicines · doi:10.3390/biomedicines9101353 · Cited by 268 · see citing works
Nutrient scavenging in cancer
Finicle, B. T., Jayashankar, V., & Edinger, A. L. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0048-x · Cited by 231 · see citing works
Active Ras Triggers Death in Glioblastoma Cells through Hyperstimulation of Macropinocytosis
Overmeyer, J. H., Kaul, A., Johnson, E. E., & Maltese, W. A. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-2036 · Cited by 229 · see citing works
The Rab5 Effector Rabankyrin-5 Regulates and Coordinates Different Endocytic Mechanisms
Schnatwinkel, C., Christoforidis, S., Lindsay, M. R., Uttenweiler‐Joseph, S., Wilm, M. S., Parton, R. G., & Zerial, M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020261 · Cited by 225 · see citing works
Metabolic Dependencies in RAS -Driven Cancers
Kimmelman, A. C. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2425 · Cited by 220 · see citing works
Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae.Preprint
Nikawa, J., Cameron, S., Toda, T., Ferguson, K. M., & Wigler, M. H. (1987) · Genes & Development · doi:10.1101/gad.1.9.931 · Cited by 225 · see citing works
Determining the macropinocytic index of cells through a quantitative image-based assay
Commisso, C., Flinn, R. J., & Bar‐Sagi, D. (2014) · Nature Protocols · doi:10.1038/nprot.2014.004 · Cited by 222 · see citing works
Self-citation
Evidence that Farnesyltransferase Inhibitors Suppress Ras Transformation by Interfering with Rho Activity
Lebowitz, P. F., Davide, J. P., & Prendergast, G. C. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6613 · Cited by 221 · see citing works
Ras p21 as a Potential Mediator of Insulin Action in Xenopus Oocytes
Korn, L. J., Siebel, C. W., McCormick, F. P., & Roth, R. A. (1987) · Science · doi:10.1126/science.3554510 · Cited by 221 · see citing works
A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.
Frost, J. A., Geppert, T. D., Cobb, M. H., & Feramisco, J. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3844 · Cited by 218 · see citing works
Self-citation
Semaphorin3a Enhances Endocytosis at Sites of Receptor–F-Actin Colocalization during Growth Cone Collapse
Fournier, A. E., Nakamura, F., Kawamoto, S., Goshima, Y., Kalb, R. G., & Strittmatter, S. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.2.411 · Cited by 215 · see citing works
Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer
Yao, W., Rose, J. L., Wang, W., Seth, S., Jiang, H., Taguchi, A., Liu, J., Yan, L., Kapoor, A., Hou, P., et al. (2019) · Nature · doi:10.1038/s41586-019-1062-1 · Cited by 214 · see citing works
On the principles of functional ordering in biological membranes
Kinnunen, P. K. J. (1991) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(91)90087-r · Cited by 211 · see citing works

Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells
Bar‐Sagi, D., McCormick, F. P., Milley, R. J., & Feramisco, J. R. (1987) · Journal of Cellular Physiology · doi:10.1002/jcp.1041330414 · Cited by 33 · see citing works
Self-citation
Microinjection of the ras oncogene protein into nonestablished rat embryo fibroblasts.
Sullivan, N. F., Sweet, R. W., Rosenberg, M. J., & Feramisco, J. R. (1986) · PubMed · Cited by 8 · see citing works
Self-citation
Uncoupling of Membrane Ruffling and Pinocytosis during Ras Signal Transduction
Li, G., D'Souza-Schorey, C., Barbieri, M. A., Cooper, J. A., & Stahl, P. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10337 · Cited by 85 · see citing works
Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells
Feramisco, J. R., Gross, M. S., Kamata, T., Rosenberg, M. J., & Sweet, R. W. (1984) · Cell · doi:10.1016/0092-8674(84)90531-2 · Cited by 389 · see citing works
Self-citation
Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS
Joneson, T., White, M. A., Wigler, M. H., & Bar‐Sagi, D. (1996) · Science · doi:10.1126/science.271.5250.810 · Cited by 371 · see citing works
Self-citation

Authors: Bar-Sagi, D., & Feramisco, J. R.
Affiliations: Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724
Cold Spring Harbor Laboratory (US)
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1986-09-05
Volume: 233
Issue: 4768
Pages: 1061-1068
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.3090687
OpenAlex: W1969560454
Cited by: 734
References: 60
Citations by year: 2026: 6 · 2025: 15 · 2024: 17 · 2023: 23 · 2022: 17 · 2021: 21 · 2020: 17 · 2019: 25 · 2018: 23 · 2017: 19 · 2016: 14 · 2015: 25 · 2014: 14 · 2013: 11 · 2012: 5
FWCI: 14.12
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA39811, CA07896)
National Institute of General Medical Sciences (GM 28277)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords: H-Ras, oncogenic Ras, ruffles, fluid-phase pinocytosis, quiescent fibroblasts, phospholipase A2, cell membrane dynamics, microinjection, tumor initiation
MeSH terms: Animals, Cell Cycle, Cell Membrane, Cells, Cultured, Culture Media, DNA, Humans, Microinjections, Oncogene Proteins, Viral, Phospholipases A, Phospholipids, Pinocytosis, Time Factors, GTP-Binding Proteins, Rats, Phospholipases A2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks