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Imaging Dopamine Receptors in the Human Brain by Positron Tomography
Abstract
Neurotransmitter receptors may be involved in a number of neuropsychiatric disease states. The ligand 3- N -[ 11 C]methylspiperone, which preferentially binds to dopamine receptors in vivo, was used to image the receptors by positron emission tomography scanning in baboons and in humans. This technique holds promise for noninvasive clinical studies of dopamine receptors in humans.
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Citations
Cited by
Pulido, R., Bravo, L., & Saura-Calixto, F. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9913458 · Cited by 2,110
Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review
Laruelle, M. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200003000-00001 · Cited by 944
Imaging endogenous dopamine competition with [11C]raclopride in the human brain
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Schlyer, D., Hitzemann, R., Lieberman, J., Angrist, B., Pappas, N., MacGregor, R., et al. (1994) · Synapse · doi:10.1002/syn.890160402 · Cited by 379
Günther, T., Tulipano, G., Dournaud, P., Bousquet, C., Csaba, Z., Kreienkamp, H.-J., Lupp, A., Korbonits, M., Castaño, J. P., Wester, H.-J., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015388 · Cited by 253
Variability in D2‐dopamine receptor density and affinity: A PET study with [11C]raclopride in man
Farde, L., Hall, H., Pauli, S., & Halldin, C. (1995) · Synapse · doi:10.1002/syn.890200303 · Cited by 175
Metadata
- Authors
- Wagner, H. N., Burns, H. D., Dannals, R. F., Wong, D. F., Langstrom, B., Duelfer, T., Frost, J. J., Ravert, H. T., Links, J. M., Rosenbloom, S. B., Lukas, S. E., Kramer, A. V., & Kuhar, M. J.
- Venue
- Science
- Published
- 1983-09-23
- Volume
- 221
- Issue
- 4617
- Pages
- 1264-1266
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976630512
- Cited by
- 741
- References
- 0
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Imaging Dopamine Receptors in the Human Brain by Positron Tomography. https://app.cochat.ai/papers/10.1126/science.6604315
- The paper
- Wagner, H. N., Burns, H. D., Dannals, R. F., Wong, D. F., Langstrom, B., Duelfer, T., Frost, J. J., Ravert, H. T., Links, J. M., Rosenbloom, S. B., Lukas, S. E., Kramer, A. V., & Kuhar, M. J. (1983). Imaging Dopamine Receptors in the Human Brain by Positron Tomography. Science. https://doi.org/10.1126/science.6604315
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