Variability in D2‐dopamine receptor density and affinity: A PET study with [11C]raclopride in man
Abstract
The variability of D 2‐dopamine receptor binding parameters in man was determined using Positron Emission Tomography (PET) and [11 C]raclopride. A saturation analysis based on five PET‐experiments was performed in each of ten men and ten women. The mean density of D 2‐dopamine receptors (B max) was 28 ± 6.9 pmol/ml (mean ± S.D.) and the apparent affinity (K dapp)9.1 ± 1.9 pmol/ml. The Hill coefficient was in all subjects close to unity (n H: 0.999 ± 0.020), thereby indicating binding to a homogeneous class of receptors. No significant differences between males and females were found in B max or K dapp. The interindividual difference in B max was statistically significant (α = 0.01). The difference in K dapp was not significant. Upregulation of the receptor density (B max) has been widely discussed as a mechanism for increased dopaminergic neurotransmission in schizophrenia. This study indicates that receptor density varies considerably in a group of healthy subjects. © 1995 Wiley‐Liss, Inc.
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The relationship between wrist temperature and extrapyramidal disease is likely modulated by the high degree of inter-individual variability in dopamine D2 receptor density, which, with its role in central thermoregulation, may lead to the high association of wrist temperature for susceptibility to extrapyramidal disease.
“This relationship is likely modulated by the high degree of inter-individual variability in dopamine D2 receptor density37, which, with its role in central thermoregulation, may lead to the high association of wrist temperature for susceptibility to extrapyramidal disease.”
From Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank (2023) · cites this paper as [37]
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Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank
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- Authors
- Farde, L., Hall, H., Pauli, S., & Halldin, C.
- Affiliations
- Karolinska University Hospital (SE)
- Venue
- Synapse
- Publisher
- Wiley
- Published
- 1995-07
- Volume
- 20
- Issue
- 3
- Pages
- 200-208
- ISSN
- 0887-4476 (ISSN-L)
- 1098-2396
- OpenAlex
- W2090291844
- Cited by
- 175
- References
- 36
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 9 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 2 · 2012: 11
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Synapse (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- National Institutes of Health (2r01mh041205-09a1)
- National Medical Research Council
- National Institute of Mental Health (MH41205-08)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- dopamine D2 receptor, receptor density, receptor binding affinity, [11C]raclopride, interindividual variability, saturation analysis, Hill coefficient, sex differences, healthy volunteers, schizophrenia, receptor up-regulation
- MeSH terms
- Adult, Aging, Brain, Brain Chemistry, Female, Humans, Image Processing, Computer-Assisted, Male, Methylation, Salicylamides, Sex Characteristics, Tomography, Emission-Computed, Receptors, Dopamine D2, Dopamine Antagonists, Raclopride
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