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Cited by 253

The DOI matches its Crossref record.

Analysis of Melatonin in Human Plasma by Gas Chromatography Negative Chemical Ionization Mass Spectrometry

Lewy, Alfred J., Markey, S. P.·1978·Science
DOI 10.1126/science.675255
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Abstract

Three techniques have been used to measure human plasma melatonin: bioassay, radioimmunoassay, and gas chromatography-mass spectrometry (GC-MS). GC-MS is theoretically capable of the greatest specificity, but in general suffers from insufficient sensitivity. Negative chemical ionization, a new technique, provides a 150-fold increase in GC-MS sensitivity for electron-capturing compounds. Negative chemical ionization GC-MS permits routine measurement in human plasma of melatonin at a concentration as low as 1 picogram per milliliter.

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Metadata

Authors
Lewy, A. J., & Markey, S. P.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1978-08-25
Volume
201
Issue
4357
Pages
741-743
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.675255
OpenAlex
W2058236355
Cited by
253
References
0
FWCI
7.27
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Analysis of Melatonin in Human Plasma by Gas Chromatography Negative Chemical Ionization Mass Spectrometry. https://app.cochat.ai/papers/10.1126/science.675255
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Lewy, A. J., & Markey, S. P. (1978). Analysis of Melatonin in Human Plasma by Gas Chromatography Negative Chemical Ionization Mass Spectrometry. Science. https://doi.org/10.1126/science.675255

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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