Cited by 418Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and related disorders

The Dim Light Melatonin Onset as a Marker for Orcadian Phase Position

Lewy, Alfred J., Sack, Robert L.·1989·Chronobiology International

Abstract

Masking is known to affect a variety of circadian rhythms, making it difficult to use them as reliable markers of circadian phase position. Melatonin may be unique in that it appears to be masked only by (bright) light. Sleep and activity do not appear to influence the melatonin rhythm. By measuring the onset of melatonin production, a clearly demarcated event, we can reliably assess circadian phase position, provided blood is sampled under dim light (the dim light melatonin onset, or DLMO). The DLMO has been useful in assessing the phase-shifting properties of bright light and in phase typing patients with chronobiologic disorders, such as winter depression.

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Crossref · 10.3109/07420528909059144

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31 of 31 references verified0 citation errors · 0 not checkable

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  • Many physiological systems that are regulated by circadian rhythms are also known to influence circadian function.

    “In support of this theory, many physiological systems that are regulated by circadian rhythms are also known to influence circadian function.”

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Authors
Lewy, A. J., & Sack, R. L.
Affiliations
Oregon Health & Science University (US)
Venue
Chronobiology International
Published
1989-01
Volume
6
Issue
1
Pages
93-102
ISSN
  • 0742-0528 (ISSN-L)
  • 1525-6073
OpenAlex
W1989645977
Cited by
418
References
31
Citations by year
2026: 9 · 2025: 13 · 2024: 9 · 2023: 13 · 2022: 21 · 2021: 12 · 2020: 24 · 2019: 20 · 2018: 14 · 2017: 16 · 2016: 15 · 2015: 14 · 2014: 12 · 2013: 19 · 2012: 8
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • Chronobiology International (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH00703, MH43016)
  • National Center for Research Resources (CRR00334)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
dim light melatonin onset, melatonin, masking, bright light exposure, phase shifting, seasonal affective disorder
MeSH terms
Animals, Circadian Rhythm, Depression, Humans, Hydrocortisone, Light, Melatonin, Seasons, Sleep, Biomarkers

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