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Translational Efficiency of Transfer RNA's: Uses of an Extended Anticodon
Abstract
Transfer RNA's are probably very strongly selected for translational efficiency. In this article, the argument is presented that the coding performance of the triplet anticodon is enhanced by selection of a matching anticodon loop and stem sequence. The anticodon plus these nearby sequence features (the extended anticodon) therefore contains more coding information than the anticodon alone and can perform more efficiently and accurately at the ribosome. This idea successfully accounts for the relative efficiencies of many transfer RNA's.
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Citations
Cites
The influence of codon context on genetic code translation
Bossi, L., & Roth, J. R. (1980) · Nature · doi:10.1038/286123a0 · Cited by 284
Cited by
A General Method for Site-specific Incorporation of Unnatural Amino Acids into Proteins
Noren, C. J., Anthony-Cahill, S. J., Griffith, M. C., & Schultz, P. G. (1989) · Science · doi:10.1126/science.2649980 · Cited by 1,019
tRNA’s Wobble Decoding of the Genome: 40 Years of Modification
Agris, P. F., Vendeix, F. A. P., & Graham, W. D. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.11.046 · Cited by 543
Natural expansion of the genetic code
Ambrogelly, A., Palioura, S., & Söll, D. (2007) · Nature Chemical Biology · doi:10.1038/nchembio847 · Cited by 361
Björk, G. R., & Hagervall, T. G. (2005) · EcoSal Plus · doi:10.1128/ecosalplus.4.6.2 · Cited by 340
An integrated, structure- and energy-based view of the genetic code
Grosjean, H., & Westhof, E. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw608 · Cited by 278
Metadata
- Authors
- Yarus, M.
- Venue
- Science
- Published
- 1982-11-12
- Volume
- 218
- Issue
- 4573
- Pages
- 646-652
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022838319
- Cited by
- 188
- References
- 1
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
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