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Ornithine Decarboxylase Is Important in Intestinal Mucosal Maturation and Recovery from Injury in Rats
Abstract
A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the newborn rat in the third week after birth. During this period, there is a rapid conversion of the mucosa from a fetal to a mature adult status. A similar increase in ornithine decarboxylase activity also accompanies the rapid recovery of the mucosa 1 week after an injury is induced by chemotherapy in adult rats. In vivo, α-difluoromethyl ornithine, a highly selective, enzyme-activated, irreversible inhibitor, suppresses these increases in mucosal ornithine decarboxylase and delays both intestinal mucosal maturation and recovery from injury. Thus increased ornithine decarboxylase activity, with the resultant increase in polyamine content, may play an essential role in intestinal mucosal maturation and regeneration in the rat.
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Cited by
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876
“4 Cell Metabolism 26, July 5, 2017 of SCFA-producing microbial species in the gut, and dietary changes that promote production of SCFAs by the microbiome can ameliorate symptoms (Frank et al., 2007; Kanauchi et al., 2002; Machiels et al., 2014; Sokol et al., 2009).”
BackgroundIntestinal Mucosal Amino Acid Catabolism
Wu, G. (1998) · The Journal of Nutrition · doi:10.1093/jn/128.8.1249 · Cited by 836
Impact of intestinal microbiota on intestinal luminal metabolome
Matsumoto, M., Kibe, R., Ooga, T., Aiba, Y., Kurihara, S., Sawaki, E., Koga, Y., & Benno, Y. (2012) · Scientific Reports · doi:10.1038/srep00233 · Cited by 334
Matsumoto, M., Kurihara, S., Kibe, R., Ashida, H., & Benno, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023652 · Cited by 290
Metadata
- Authors
- Lux, G. D., Marton, L. J., & Baylin, S. B.
- Venue
- Science
- Published
- 1980-10-10
- Volume
- 210
- Issue
- 4466
- Pages
- 195-198
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044178660
- Cited by
- 346
- References
- 0
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lux, G. D., Marton, L. J., & Baylin, S. B. (1980). Ornithine Decarboxylase Is Important in Intestinal Mucosal Maturation and Recovery from Injury in Rats. Science. https://doi.org/10.1126/science.6774420
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