Cited by 159Memory and Neural MechanismsNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

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Opiate Antagonists Improve Spatial Memory

Gallagher, Michela, King, Richard A., Young, Nancy B.·1983·Science

DOI 10.1126/science.6879198

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Abstract

Rats trained on an eight-arm radial maze were challenged by placing the maze in new spatial environments. Administration of opiate antagonists, either naloxone or diprenorphine, after exposure to the new environments significantly improved subsequent performance. The effect of naloxone on spatial memory was attenuated when drug administration occurred 2 hours after maze exposure.

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Authors: Gallagher, M., King, R. A., & Young, N. B.
Affiliations: University of North Carolina at Chapel Hill (US)
ORCID: Gallagher, Michela
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1983-09-02
Volume: 221
Issue: 4614
Pages: 975-976
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.6879198
OpenAlex: W2068964932
Cited by: 159
References: 18
Citations by year: 2021: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 3
FWCI: 8.21
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k02mh000406-10)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: opioid antagonists, spatial memory, naloxone, diprenorphine, eight-arm radial maze, spatial environment, memory enhancement, opioid receptors
MeSH terms: Animals, Behavior, Animal, Male, Memory, Naloxone, Spatial Behavior, Rats

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Opiate Antagonists Improve Spatial Memory

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