The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Blood-Brain Glucose Transfer: Repression in Chronic Hyperglycemia
Abstract
Diabetic patients with increased plasma glucose concentrations may develop cerebral symptoms of hypoglycemia when their plasma glucose is rapidly lowered to normal concentrations. The symptoms may indicate insufficient transport of glucose from blood to brain. In rats with chronic hyperglycemia the maximum glucose transport capacity of the blood-brain barrier decreased from 400 to 290 micromoles per 100 grams per minute. When plasma glucose was lowered to normal values, the glucose transport rate into brain was 20 percent below normal. This suggests that repressive changes of the glucose transport mechanism occur in brain endothelial cells in response to increased plasma glucose.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In rats with chronic hyperglycemia, the maximum glucose transport capacity of the BBB decreased from 400 to 290 micromoles per 100 grams per minute, and the glucose transport rate in the brain decreased to 20 percent below normal when plasma glucose was lowered to normal values [3].”
From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [3]
In the citing paper
“On the other hand, repressive adaptation of glucose transport across the blood-brain-barrier (BBB) occurs in response to chronic hyperglycemia to prevent a rise in brain glucose content [3].”
From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [3]
Citations
Cites
Crone, C. (1963) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1963.tb02652.x · Cited by 1,157
Self-citationThe Concept of a Blood-Brain Barrier
(1980) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(80)90073-7 · Cited by 805
Transport of glucose from blood to brain.
Lund‐Andersen, H. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.2.305 · Cited by 474
Facilitated transfer of glucose from blood into brain tissue.
Crone, C. G. (1965) · The Journal of Physiology · doi:10.1113/jphysiol.1965.sp007748 · Cited by 439
Self-citationInduction processes in blood-brain transfer of ketone bodies during starvation
GJEDDE, A. H., & Crone, C. G. (1975) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1975.229.5.1165 · Cited by 239
Self-citationGJEDDE, A. H., Hansen, A. J., & Siemkowicz, E. (1980) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1980.tb06540.x · Cited by 177
Self-citationBeta-hydroxybutyrate transport in rat brain: developmental and dietary modulations
Moore, T., Lione, A., Sugden, M. C., & Regen, D. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.230.3.619 · Cited by 140
DeFronzo, R. A., Hendler, R., & Christensen, N. J. (1980) · Diabetes · doi:10.2337/diab.29.2.125 · Cited by 120
Pentobarbital Anesthesia Reduces Blood–Brain Glucose Transfer in the Rat
GJEDDE, A. H., & Rasmussen, M. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb09013.x · Cited by 119
Self-citationBradbury, M. W. B. (1979) · Trends in Neurosciences · doi:10.1016/0166-2236(79)90016-x · Cited by 81
Rapid steady‐state analysis of blood‐brain glucose transfer in rat
GJEDDE, A. H. (1980) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1980.tb06541.x · Cited by 78
Self-citationDahlquist, G., & Persson, B. (1976) · Pediatric Research · doi:10.1203/00006450-197611000-00002 · Cited by 76
DeFronzo, R. A., Andres, R., Bledsoe, T. A., Boden, G., Faloona, G. A., & Tobin, J. D. (1977) · Diabetes · doi:10.2337/diab.26.5.445 · Cited by 70
Insulin Receptor Status in Disease States of Man
Bar, R. S. (1977) · Archives of Internal Medicine · doi:10.1001/archinte.1977.03630160042011 · Cited by 67
Counterregulatory Hormonal Responses to Rapid Glucose Lowering in Diabetic Man
Lilavivathana, U., Brodows, R. G., Woolf, P. D., & Campbell, R. G. (1979) · Diabetes · doi:10.2337/diab.28.10.873 · Cited by 57
Bindslev, N. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012707 · Cited by 42
The transport of ketone bodies into the brain of the rat (in vivo)
Daniel, P. M., Love, E. R., Moorhouse, S. R., & PRATT, O. E. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90086-7 · Cited by 41
The metabolic response to glycemic control by the artificial pancreas in diabetic man
Zinman, B., Stokes, E. F., Albisser, A. M., Hanna, A. K., Minuk, H. L., Stein, A. N., Leibel, B. S., & Marliss, E. B. (1979) · Metabolism · doi:10.1016/0026-0495(79)90190-2 · Cited by 41
Metabolic rhythms in normal and diabetic man. Studies in insulin-treated diabetes.
Kg, A., Dornhorst, A., & As, R. (1975) · PubMed · Cited by 35
ESTIMATION OF THE KINETIC PARAMETERS OF UNIDIRECTIONAL TRANSPORT ACROSS THE BLOOD‐BRAIN BARRIER
Cunningham, V. J., & Sarna, G. S. (1979) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1979.tb05172.x · Cited by 29
Barnett, G., & Ličko, V. (1977) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(77)90003-7 · Cited by 15
PRINCIPLES OF GENERAL NEUROLOGY
Simpson, J. A. (1970) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.33.5.719-b · Cited by 11
Flagged first, then by citations
Research works printed but not linked: 4
- Crone, C., Capillary Permeability, Alfred Benzon Symposium 2: 447 (1970).
- GAMMELTOFT, S, INSULIN CHEM STRUCTU: 271 (1980).
- MCCALL, A.L., DIABETES 28: 381 (1979).
- WYKE, B.D., ELECTROENCEPHALOGRAPHIC STUDIES IN THE SYNDROME OF RELATIVE CEREBRAL HYPOGLYCAEMIA, ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY 11: 602 (1959).
Cited by
Sorted by citations
Siddiqui-Jain, A., Grand, C. L., Bearss, D. J., & Hurley, L. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182256799 · Cited by 2,274
Type 2 diabetes mellitus, cognitive impairment and dementia
Stewart, R., & Liolitsa, D. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00027.x · Cited by 562
Unger, R. H., & Grundy, S. M. (1985) · Diabetologia · doi:10.1007/bf00273856 · Cited by 452
Regulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells
Mann, G. E., Yudilevich, D. L., & Sobrevia, L. (2003) · Physiological Reviews · doi:10.1152/physrev.00022.2002 · Cited by 430
The Impact of Diabetes on the CNS
McCall, A. L. (1992) · Diabetes · doi:10.2337/diab.41.5.557 · Cited by 340
Metadata
- Authors
- Gjedde, A., & Crone, C.
- Affiliations
- University of Copenhagen (DK)
- ORCID
- Gjedde, Albert
- Venue
- Science
- Published
- 1981-10-23
- Volume
- 214
- Issue
- 4519
- Pages
- 456-457
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091625139
- Cited by
- 235
- References
- 22
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- chronic hyperglycemia, glucose transport, blood-brain barrier, brain endothelial cells, plasma glucose, rats
- MeSH terms
- Animals, Biological Transport, Blood-Brain Barrier, Brain, Diabetes Mellitus, Experimental, Glucose, Hyperglycemia, Insulin, Kinetics, Regional Blood Flow, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
