Cited by 235Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsIon Transport and Channel Regulation

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Blood-Brain Glucose Transfer: Repression in Chronic Hyperglycemia

Gjedde, Albert, Crone, Christian·1981·Science

DOI 10.1126/science.7027439

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Abstract

Diabetic patients with increased plasma glucose concentrations may develop cerebral symptoms of hypoglycemia when their plasma glucose is rapidly lowered to normal concentrations. The symptoms may indicate insufficient transport of glucose from blood to brain. In rats with chronic hyperglycemia the maximum glucose transport capacity of the blood-brain barrier decreased from 400 to 290 micromoles per 100 grams per minute. When plasma glucose was lowered to normal values, the glucose transport rate into brain was 20 percent below normal. This suggests that repressive changes of the glucose transport mechanism occur in brain endothelial cells in response to increased plasma glucose.

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Authors: Gjedde, A., & Crone, C.
Affiliations: University of Copenhagen (DK)
ORCID: Gjedde, Albert
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1981-10-23
Volume: 214
Issue: 4519
Pages: 456-457
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.7027439
OpenAlex: W2091625139
Cited by: 235
References: 22
Citations by year: 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 4
FWCI: 5.41
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: chronic hyperglycemia, glucose transport, blood-brain barrier, brain endothelial cells, plasma glucose, rats
MeSH terms: Animals, Biological Transport, Blood-Brain Barrier, Brain, Diabetes Mellitus, Experimental, Glucose, Hyperglycemia, Insulin, Kinetics, Regional Blood Flow, Rats

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Blood-Brain Glucose Transfer: Repression in Chronic Hyperglycemia

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