The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hemin Lyses Malaria Parasites
Abstract
Malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin IX chloride (hemin) or by a chloroquine-hemin complex in amounts that could be produced by release of less than 0.1 percent of the heme in erythrocytic hemoglobin. This effect of hemin may explain the protection against malaria provided by thalassemia and other conditions causing intracellular denaturation of hemoglobin. The toxicity of the chloroquine-hemin complex may explain the selective antimalarial action of chloroquine.
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Citations
Cites
Mechanism of hemolysis induced by ferriprotoporphyrin IX
Chou, A. C., & Fitch, C. D. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110302 · Cited by 168
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Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941
Quinoline Antimalarials Mechanisms of Action and Resistance and Prospects for New Agents
Foley, M. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00012-6 · Cited by 592
Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
Pamplona, A., Ferreira, A., Balla, J., Jeney, V., Balla, G., Epiphanio, S., Chora, Â., Rodrigues, C. D., Gregoire, I. P., Cunha-Rodrigues, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1586 · Cited by 560
Therapeutic and Medicinal Uses of Terpenes
Cox-Georgian, D., Ramadoss, N., Dona, C., & Basu, C. (2019) · Medicinal Plants · doi:10.1007/978-3-030-31269-5_15 · Cited by 429
Membrane Transport in the Malaria-Infected Erythrocyte
Kirk, K. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.495 · Cited by 405
Metadata
- Authors
- Orjih, A. U., Banyal, H. S., Chevli, R., & Fitch, C. D.
- Venue
- Science
- Published
- 1981-11-06
- Volume
- 214
- Issue
- 4521
- Pages
- 667-669
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2003590875
- Cited by
- 204
- References
- 1
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Orjih, A. U., Banyal, H. S., Chevli, R., & Fitch, C. D. (1981). Hemin Lyses Malaria Parasites. Science. https://doi.org/10.1126/science.7027441
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
