The DOI matches its Crossref record.
Human Aldehyde Dehydrogenase: Mechanism of Inhibition of Disulfiram
Abstract
Disulfiram labeled with carbon-14 reacts specifically with human liver aldehyde dehydrogenase E1 with loss of catalytic activity and no incorporation of label. Carbon-14-labeled diethyldithiocarbamate is formed and the number of enzyme sulfhydryl groups decreases from 34 to 30 during this process. Activity is recovered by 2-mercaptoethanol but not by glutathione, the physiological reducing agent.
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Citations
Cited by
Volkow, N. D., & Blanco, C. (2023) · World psychiatry · doi:10.1002/wps.21073 · Cited by 503
A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites
Johansson, B. (1992) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1992.tb03310.x · Cited by 349
Mullarky, E., Lucki, N. C., Beheshti Zavareh, R., Anglin, J. L., Gomes, A. P., Nicolay, B. N., Wong, J. C. Y., Christen, S., Takahashi, H., Singh, P. K., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521548113 · Cited by 333
High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system.
McCaffery, P., & Dräger, U. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7772 · Cited by 266
Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder
Burnette, E. M., Nieto, S. J., Grodin, E. N., Meredith, L. R., Hurley, B., Miotto, K., Gillis, A. J., & Ray, L. A. (2022) · Drugs · doi:10.1007/s40265-021-01670-3 · Cited by 169
Metadata
- Authors
- Vallari, R. C., & Pietruszko, R.
- Venue
- Science
- Published
- 1982-05-07
- Volume
- 216
- Issue
- 4546
- Pages
- 637-639
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2014622954
- Cited by
- 234
- References
- 0
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vallari, R. C., & Pietruszko, R. (1982). Human Aldehyde Dehydrogenase: Mechanism of Inhibition of Disulfiram. Science. https://doi.org/10.1126/science.7071604
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
