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Mus poschiavinus Y Chromosome in the C57BL/6J Murine Genome Causes Sex Reversal
Abstract
When the Y chromosome from Mus poschiavinus (Y POS ) is transferred onto the C57BL/6J genome, XY individuals develop as females with two ovaries, or as hermaphrodites. No XY individual develops normal testes. Although C57BL/6J-Y POS XY females are rarely fertile, most hermaphrodites with normal male genitalia sire offspring. Thus, the Mus poschiavinus Y chromosome carries a form of the Y-linked testis-determining locus different from that present in the C57BL/6J inbred strain. This gene interacts abnormally with autosomal or X-linked testis-determining loci of the C57BL/6J genome to prevent normal testicular differentiation. Divergence of the Y-linked testis-determining gene may be involved in mammalian speciation.
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Cited by
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Koubova, J., Menke, D. B., Zhou, Q., Capel, B., Griswold, M. D., & Page, D. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510813103 · Cited by 941
One tissue, two fates: molecular genetic events that underlie testis versus ovary development
Brennan, J., & Capel, B. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1381 · Cited by 549
Svingen, T., & Koopman, P. (2013) · Genes & Development · doi:10.1101/gad.228080.113 · Cited by 386
Sry: the master switch in mammalian sex determination
Kashimada, K., & Koopman, P. (2010) · Development · doi:10.1242/dev.048983 · Cited by 351
The biochemical role of SRY in sex determination
R. Harley, V., & N. Goodfellow, P. (1994) · Molecular Reproduction and Development · doi:10.1002/mrd.1080390211 · Cited by 114
Metadata
- Authors
- Eicher, E. M., Washburn, L. L., Whitney, J. B., & Morrow, K. E.
- Venue
- Science
- Published
- 1982-08-06
- Volume
- 217
- Issue
- 4559
- Pages
- 535-537
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976023763
- Cited by
- 289
- References
- 0
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mus poschiavinus Y Chromosome in the C57BL/6J Murine Genome Causes Sex Reversal. https://app.cochat.ai/papers/10.1126/science.7089579
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- Eicher, E. M., Washburn, L. L., Whitney, J. B., & Morrow, K. E. (1982). Mus poschiavinus Y Chromosome in the C57BL/6J Murine Genome Causes Sex Reversal. Science. https://doi.org/10.1126/science.7089579
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