The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis
Abstract
A wide variety of toxic chemicals cause blebbing of the plasma membrane in isolated hepatocytes. These alterations in surface structure occur well before cell death. The formation of blebs appears to be directly related to changes in the concentration of extramitochondrial calcium ions. These changes probably reduce the ability of the hepatocyte cytoskeleton to maintain normal surface morphology. The concentration of soluble thiols, notably glutathione, appears to regulate the size of the extramitochondrial calcium ion pool. Disturbances in intracellular thiol and calcium ion homeostasis therefore seem to be responsible for the surface blebbing observed during toxic injury to isolated hepatocytes.
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Cites
Calmodulin Plays a Pivotal Role in Cellular Regulation
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A scheme for the colorimetric determination of microgram amounts of thiols
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Hormonal effects on calcium homeostasis in isolated hepatocytes.
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Bellomo, G., Jewell, S. A., Thor, H., & Orrenius, S. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.22.6842 · Cited by 302
Self-citationLötscher, H. R., Winterhalter, K. H., Carafoli, E., & Richter, C. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70565-1 · Cited by 223
A Correlation between Glutathione Levels and Cellular Damage in Isolated Hepatocytes
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Cited by
Glutathione: Toxicological Implications
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Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?
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Self-citationDalle-Donne, I. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00749-3 · Cited by 398
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Metadata
- Authors
- Jewell, S. A., Bellomo, G., Thor, H., Orrenius, S., & Smith, M. T.
- Venue
- Science
- Published
- 1982-09-24
- Volume
- 217
- Issue
- 4566
- Pages
- 1257-1259
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065997722
- Cited by
- 549
- References
- 12
- FWCI
- 28.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jewell, S. A., Bellomo, G., Thor, H., Orrenius, S., & Smith, M. T. (1982). Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis. Science. https://doi.org/10.1126/science.7112127
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
