Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?
Abstract
The sensitivity of mitochondrial DNA to damage by mutagens predisposes mitochondria to injury on exposure of cells to genotoxins or oxidative stress. Damage to the mitochondrial genome causing mutations or loss of mitochondrial gene products, or to some nuclear genes encoding mitochondrial membrane proteins, may accelerate release of reactive species of oxygen. Such aberrant mitochondria may contribute to cellular aging and promotion of cancer.
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Errors in mitochondrial gene expression may result in dysfunctional mitochondrial subunits.
“As the integrity of mitochondrial DNA is essential for mitochondrial function, errors in gene expression may in result in dysfunctional mitochondrial subunits [15].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [15]
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“Dysfunctional mitochondria are then thought to contribute to further ROS leakage, in a continuous vicious cycle of damage accumulation [18, 19].”
Background
- Authors
- Bandy, B., & Davison, A. J.
- Affiliations
- Simon Fraser University (CA)
- Corresponding author
- Bandy, Brian
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 1990
- Volume
- 8
- Issue
- 6
- Pages
- 523-539
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2048339025
- Cited by
- 550
- References
- 218
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 2 · 2022: 12 · 2021: 5 · 2020: 10 · 2019: 4 · 2018: 7 · 2017: 13 · 2016: 19 · 2015: 17 · 2014: 26 · 2013: 22 · 2012: 20
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial DNA mutations, oxidative stress, carcinogenesis, cellular aging, reactive oxygen species, genotoxins, mitochondrial membrane proteins, mitochondrial dysfunction
- MeSH terms
- Aging, Animals, DNA, Mitochondrial, Humans, Mitochondria, Mutation, Neoplasms, Oxygen
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