The DOI matches its Crossref record.
Site-Specific, Sustained Release of Drugs to the Brain
Abstract
A dihydropyridine-pyridinium salt type of redox system is used in a general and flexible method for site-specific or sustained delivery (or both) of drugs to the brain. A biologically active compound linked to a lipoidal dihydropyridine carrier easily penetrates the blood-brain barrier. Oxidation of the carrier part in vivo to the ionic pyridinium salt prevents its elimination from the brain, while elimination from the general circulation is accelerated. Subsequent cleavage of the quaternary carrier-drug species results in sustained delivery of the drug in the brain and facile elimination of the carrier part.
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Citations
Cited by
Singh, R. K., Kumar, S., Prasad, D. N., & Bhardwaj, T. R. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.04.001 · Cited by 282
Targeting receptor-ligand chemistry for drug delivery across blood-brain barrier in brain diseases
Anthony, D. P., Hegde, M., Shetty, S. S., Rafic, T., Mutalik, S., & Rao, B. S. S. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119326 · Cited by 110
Murakami, T., Bodor, E., & Bodor, N. (2023) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2023.2203857 · Cited by 41
Self-citation
Metadata
- Authors
- Bodor, N., Farag, H. H., & Brewster, M. E.
- Venue
- Science
- Published
- 1981-12-18
- Volume
- 214
- Issue
- 4527
- Pages
- 1370-1372
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2018950212
- Cited by
- 181
- References
- 0
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Site-Specific, Sustained Release of Drugs to the Brain. https://app.cochat.ai/papers/10.1126/science.7313698
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- Bodor, N., Farag, H. H., & Brewster, M. E. (1981). Site-Specific, Sustained Release of Drugs to the Brain. Science. https://doi.org/10.1126/science.7313698
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
