Targeting receptor-ligand chemistry for drug delivery across blood-brain barrier in brain diseases

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010

Ostrom, Q. T., Gittleman, H. R., Farah, P., Ondracek, A., Chen, Y., Wolinsky, Y., Stroup, N. E., Kruchko, C. A., & Barnholtz‐Sloan, J. S. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not151 · Cited by 12,049 · see citing works

α-Synuclein in Lewy bodies

Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382 · see citing works

Alzheimer's disease: the amyloid cascade hypothesis

Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works

Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Feigin, V. L., Nichols, E., Alam, T., Bannick, M. S., Beghi, E., Blake, N., Culpepper, W. J., Dorsey, E. R., Elbaz, A., Ellenbogen, R. G., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30499-x · Cited by 5,644 · see citing works

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works

Pericytes regulate the blood–brain barrier

Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843 · see citing works

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

Gilbert, M. R., Dignam, J. J., Armstrong, T. S., Wefel, J. S., Blumenthal, D. T., Vogelbaum, M. A., Colman, H., Chakravarti, A., Pugh, S., Won, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1308573 · Cited by 2,834 · see citing works

The blood-brain barrier: Bottleneck in brain drug development

Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798 · see citing works

The blood-brain barrier/neurovascular unit in health and disease

Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661 · see citing works

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works

The blood–brain barrier: an overview

Ballabh, P., Braun, A., & Nedergaard, M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.016 · Cited by 2,276 · see citing works

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011–2015

Ostrom, Q. T., Gittleman, H. R., Truitt, G., Boscia, A. L., Kruchko, C., & Barnholtz‐Sloan, J. S. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy131 · Cited by 2,163 · see citing works

The blood–brain barrier and blood–tumour barrier in brain tumours and metastases

Arvanitis, C., Ferraro, G. B., & Jain, R. K. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0205-x · Cited by 1,841 · see citing works

Targeted drug delivery via the folate receptor

Sudimack, J. J., & Lee, R. J. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00062-9 · Cited by 1,477 · see citing works

Nanoparticle-based theranostic agents

Xie, J., Lee, S., & Chen, X. S. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.07.009 · Cited by 1,423 · see citing works

Convection-enhanced delivery of macromolecules in the brain.

Bobo, R. H., Laske, D. W., Akbaşak, A., Morrison, P. F., Dedrick, R. L., & Oldfield, E. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2076 · Cited by 1,414 · see citing works

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397 · see citing works

Blood–brain barrier delivery

Pardridge, W. M. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2006.10.013 · Cited by 1,191 · see citing works

Astrocyte-endothelial Interactions and Blood-Brain Barrier Permeability*

Abbott, N. J. (2002) · Journal of Anatomy · doi:10.1046/j.1469-7580.2002.00064.x · Cited by 1,168 · see citing works

ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y. D., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., et al. (2012) · Science · doi:10.1126/science.1217697 · Cited by 1,050 · see citing works

Endocytic mechanisms for targeted drug delivery☆

Bareford, L. M., & Swaan, P. W. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.06.008 · Cited by 1,035 · see citing works

Modern methods for delivery of drugs across the blood–brain barrier

Chen, Y., & Liu, L. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.010 · Cited by 1,005 · see citing works

Current Strategies for Brain Drug Delivery

Dong, X. (2018) · Theranostics · doi:10.7150/thno.21254 · Cited by 954 · see citing works

Liposomal Drug Delivery Systems: An Update Review

Samad, A., Sultana, Y., & Aqil, M. (2007) · Current Drug Delivery · doi:10.2174/156720107782151269 · Cited by 909 · see citing works

Functional morphology of the blood–brain barrier in health and disease

Liebner, S., Dijkhuizen, R. M., Reiss, Y., Plate, K. H., Agalliu, D., & Constantin, G. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1815-1 · Cited by 872 · see citing works

Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases

Gabathuler, R. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.028 · Cited by 804 · see citing works

Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier.

Kreuter, J., Shamenkov, D., Petrov, V., Ramge, P., Cychutek, K., Koch-Brandt, C., & Alyautdin, R. (2002) · Journal of drug targeting · doi:10.1080/10611860290031877 · Cited by 801 · see citing works

Passage of cytokines across the blood–brain barrier

Banks, W. A., Kastin, A. J., & Broadwell, R. D. (1996) · Neuroimmunomodulation · doi:10.1159/000097202 · Cited by 778 · see citing works

The Blood-Brain Barrier and Cancer: Transporters, Treatment, and Trojan Horses

Deeken, J. F., & Löscher, W. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2854 · Cited by 723 · see citing works

Base excision repair of oxidative DNA damage and association with cancer and aging

Maynard, S., Schurman, S. H., Harboe, C., de Souza-Pinto, N. C., & Bohr, V. A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn250 · Cited by 685 · see citing works

CNS Delivery Via Adsorptive Transcytosis

Hervé, F., Ghinea, N., & Scherrmann, J.-M. (2008) · The AAPS Journal · doi:10.1208/s12248-008-9055-2 · Cited by 676 · see citing works

The influence of cytokines on the integrity of the blood-brain barrier in vitro

de Vries, H. E., Blom-Roosemalen, M. C. M., van Oosten, M., de Boer, A. G., van Berkel, T. J. C., Breimer, D. D., & Kuiper, J. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00148-4 · Cited by 666 · see citing works

The blood-brain barrier: an engineering perspective

Wong, A. D., Ye, M., Levy, A. F., Rothstein, J. D., Bergles, D. E., & Searson, P. C. (2013) · Frontiers in Neuroengineering · doi:10.3389/fneng.2013.00007 · Cited by 662 · see citing works

Brain drug delivery of small molecules using immunoliposomes

Huwyler, J., Wu, D., & Pardridge, W. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14164 · Cited by 656 · see citing works

Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation

Luissint, A.-C., Artus, C., Glacial, F., Ganeshamoorthy, K., & Couraud, P.-O. (2012) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-9-23 · Cited by 654 · see citing works

Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier

Lockman, P. R., Mumper, R. J., Khan, M. A., & Allen, D. D. (2002) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120001481 · Cited by 592 · see citing works

Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood–brain barrier (BBB)

Ulbrich, K., Hekmatara, T., Herbert, E., & Kreuter, J. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.08.021 · Cited by 591 · see citing works

Polymeric nanoparticles for drug delivery to the central nervous system

Patel, T., Zhou, J., Piepmeier, J. M., & Saltzman, W. M. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.12.006 · Cited by 569 · see citing works

A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier

Dehouck, B., Fénart, L., Dehouck, M., Pierce, A., Torpier, G., & Cecchelli, R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.4.877 · Cited by 568 · see citing works

Blood–Brain Barrier Transport of Therapeutics via Receptor-Mediation

Jones, A. R., & Shusta, E. V. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9379-0 · Cited by 549 · see citing works

Glial influence on the blood brain barrier

Alvarez, J. I., Katayama, T., & Prat, A. (2013) · Glia · doi:10.1002/glia.22575 · Cited by 542 · see citing works

Utilizing the folate receptor for active targeting of cancer nanotherapeutics

Zwicke, G. L., Mansoori, G. A., & Jeffery, C. J. (2012) · Nano Reviews · doi:10.3402/nano.v3i0.18496 · Cited by 538 · see citing works

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

Wiley, D. T., Webster, P. C., Gale, A., & Davis, M. E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307152110 · Cited by 521 · see citing works

Progress and perspectives on targeting nanoparticles for brain drug delivery

Gao, H. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.05.013 · Cited by 505 · see citing works

Getting into the Brain

Patel, B. M., Goyal, B. R., Bhadada, S. V., Bhatt, J. S., & Amin, A. F. (2008) · CNS Drugs · doi:10.2165/0023210-200923010-00003 · Cited by 466 · see citing works

Identification and Design of Peptides as a New Drug Delivery System for the Brain

Demeule, M., Régina, A., Ché, C., Poirier, J., Nguyen, T., Gabathuler, R., Castaigne, J., & Béliveau, R. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.131318 · Cited by 464 · see citing works

An update on the diagnosis and treatment of Parkinson disease

Rizek, P., Kumar, N., & Jog, M. (2016) · Canadian Medical Association Journal · doi:10.1503/cmaj.151179 · Cited by 455 · see citing works

Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

Cabezas, R., Ávila, M. F., González, J., El-Bachá, R. D. S., Báez-Jurado, E., García‐Segura, L. M., Jurado-Coronel, J. C., Capani, F., Cardona‐Gómez, G. P., & Barreto, G. E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00211 · Cited by 453 · see citing works

Drug Targeting to the Brain

Pardridge, W. M. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9324-2 · Cited by 450 · see citing works

Folate-receptor-targeted delivery of doxorubicin nano-aggregates stabilized by doxorubicin–PEG–folate conjugate

Yoo, H. S., & Park, T. G. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.017 · Cited by 443 · see citing works

Neurological Diseases in Relation to the Blood–Brain Barrier

Rosenberg, G. A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.197 · Cited by 442 · see citing works

Epidemiology of Brain Tumors

Ohgaki, H. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-492-0_14 · Cited by 423 · see citing works

Frontotemporal dementia

Olney, N. T., Spina, S., & Miller, B. L. (2017) · Neurologic Clinics · doi:10.1016/j.ncl.2017.01.008 · Cited by 419 · see citing works

Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier

Lajoie, J. M., & Shusta, E. V. (2015) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124852 · Cited by 399 · see citing works

Human Blood—Brain Barrier Insulin Receptor

Pardridge, W. M., Eisenberg, J., & Yang, J. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb07167.x · Cited by 399 · see citing works

Transferrin and Transferrin Receptor Function in Brain Barrier Systems

Moos, T., & Morgan, E. H. (2000) · Cellular and Molecular Neurobiology · doi:10.1023/a:1006948027674 · Cited by 394 · see citing works

Dementia with Lewy bodies: an update and outlook

Outeiro, T. F., Koss, D. J., Erskine, D., Walker, L., Kurzawa-Akanbi, M., Burn, D., Donaghy, P., Morris, C., Taylor, J.-P., Thomas, A., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0306-8 · Cited by 381 · see citing works

Folate-mediated targeting: from diagnostics to drug and gene delivery

Leamon, C. P., & Low, P. S. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(00)01594-4 · Cited by 377 · see citing works

Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels.

Golden, P. L., Maccagnan, T. J., & Pardridge, W. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119125 · Cited by 369 · see citing works

Scavenger Receptor Structure and Function in Health and Disease

Abdul‐Zani, I., Stephen, S. L., Mughal, N. A., Russell, D., Homer‐Vanniasinkam, S., Wheatcroft, S. B., & Ponnambalam, S. (2015) · Cells · doi:10.3390/cells4020178 · Cited by 363 · see citing works

Transporter-Mediated Permeation of Drugs Across the Blood–Brain Barrier

Tamai, I., & Tsuji, A. (2000) · Journal of Pharmaceutical Sciences · doi:10.1002/1520-6017(200011)89:11 · Cited by 363 · see citing works

Human blood-brain barrier transferrin receptor

Pardridge, W. M., Eisenberg, J., & Yang, J. (1987) · Metabolism · doi:10.1016/0026-0495(87)90099-0 · Cited by 356 · see citing works

Drug Targeting to the Brain

de Boer, A. G., & Gaillard, P. J. (2006) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105237 · Cited by 355 · see citing works

Lactoferrin-conjugated PEG–PLA nanoparticles with improved brain delivery: In vitro and in vivo evaluations

Hu, K., Li, J., Shen, Y., Lü, W., Gao, X., Zhang, Q., & Jiang, X. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.10.016 · Cited by 354 · see citing works

Pin1, a new player in the fate of HIF-1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer’s disease risk factor

Lonati, E., Brambilla, A., Milani, C., Masserini, M., Palestini, P., & Bulbarelli, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00001 · Cited by 347 · see citing works

Current Pharmacotherapy for Alzheimer's Disease

Lleó, A., Greenberg, S. M., & Growdon, J. H. (2005) · Annual Review of Medicine · doi:10.1146/annurev.med.57.121304.131442 · Cited by 346 · see citing works

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion.

Blasberg, R. G., Patlak, C. S., & Fenstermacher, J. D. (1975) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30311-3 · Cited by 344 · see citing works

Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease

Fleisher, A., Raman, R., Siemers, E., Becerra, L. M., Clark, C. M., Dean, R. A., Farlow, M. R., Galvin, J. E., Peskind, E. R., Quinn, J. F., et al. (2008) · Archives of Neurology · doi:10.1001/archneur.65.8.1031 · Cited by 332 · see citing works

Drug treatment of epilepsy in adults

Schmidt, D., & Schachter, S. C. (2014) · BMJ · doi:10.1136/bmj.g254 · Cited by 327 · see citing works

Insulin-Binding Sites in the Rat Brain: In Vivo Localization to the Circumventricular Organs by Quantitative Radioautography*

van Houten, M., Posner, B. I., Kopriwa, B. M., & Brawer, J. R. (1979) · Endocrinology · doi:10.1210/endo-105-3-666 · Cited by 321 · see citing works

Strategies for transporting nanoparticles across the blood–brain barrier

Zhang, T.-T., Li, W., Meng, G., Wang, P., & Liao, W. (2016) · Biomaterials Science · doi:10.1039/c5bm00383k · Cited by 308 · see citing works

Ionizing radiation and the risk of brain and central nervous system tumors: a systematic review

Braganza, M. Z., Kitahara, C. M., de González, A. B., Inskip, P. D., Johnson, K. J., & Rajaraman, P. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos208 · Cited by 306 · see citing works

Dementia

Duong, S., Patel, T., & Chang, F. (2017) · Canadian Pharmacists Journal / Revue des Pharmaciens du Canada · doi:10.1177/1715163517690745 · Cited by 304 · see citing works

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization

Sánchez‐López, E., Ettcheto, M., Egea, M. A., Espina, M., Cano, A. C., Calpena, A. C., Camins, A., Carmona-Ule, N., Silva, A. M., Souto, E. B., et al. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0356-z · Cited by 297 · see citing works

Targeting Rat Anti-Mouse Transferrin Receptor Monoclonal Antibodies through Blood-Brain Barrier in Mouse

Lee, H., Engelhardt, B., Lesley, J., Bickel, U., & Pardridge, W. M. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35388-1 · Cited by 287 · see citing works

Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

Liu, Y., Huang, R., Han, L., Ke, W., Shao, K., Ye, L., Lou, J., & Jiang, C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.051 · Cited by 281 · see citing works

Arginine-glycine-aspartic acid (RGD)-peptide binds to both tumor and tumor-endothelial cells in vivo.

Zitzmann, S., Ehemann, V., & Schwab, M. (2002) · PubMed · Cited by 265 · see citing works

Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain

Kreuter, J., Hekmatara, T., Dreis, S., Vogel, T., Gelperina, S. E., & Langer, K. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.12.012 · Cited by 263 · see citing works

Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: Preparation, characterization and efficacy in Parkinson's disease

Hu, K., Shi, Y., Jiang, W., Han, J., Huang, S., & Jiang, X. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.05.062 · Cited by 261 · see citing works

Selection of phage‐displayed llama single‐domain antibodies that transmigrate across human blood‐brain barrier endothelium

Muruganandam, A., Tanha, J., Narang, S. A., & Stanimirovic, D. B. (2001) · The FASEB Journal · doi:10.1096/fj.01-0343fje · Cited by 261 · see citing works

Targeting the insulin receptor: nanoparticles for drug delivery across the blood–brain barrier (BBB)

Ulbrich, K., Knobloch, T., & Kreuter, J. (2011) · Journal of Drug Targeting · doi:10.3109/10611861003734001 · Cited by 259 · see citing works

Targeted Molecular Therapy of GBM

Mischel, P. S., & Cloughesy, T. F. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00006.x · Cited by 245 · see citing works

Lewy Body Dementias

Gomperts, S. N. (2016) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000309 · Cited by 241 · see citing works

Targeted delivery of proteins across the blood–brain barrier

Spencer, B. J., & Verma, I. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702170104 · Cited by 239 · see citing works

Transferrin conjugated nontoxic carbon dots for doxorubicin delivery to target pediatric brain tumor cells

Li, S., Amat, D., Peng, Z., Vanni, S., Raskin, S. I., Angulo, G. D., Othman, A. M., Graham, R. M., & Leblanc, R. M. (2016) · Nanoscale · doi:10.1039/c6nr05055g · Cited by 228 · see citing works

High transcytosis of melanotransferrin (P97) across the blood–brain barrier

Demeule, M., Poirier, J., Jodoin, J., Bertrand, Y., Desrosiers, R. R., Dagenais, C., Nguyen, T., Lanthier, J., Gabathuler, R., Kennard, M. L., et al. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01201.x · Cited by 222 · see citing works

The blood–brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells

Abulrob, A., Sprong, H., Henegouwen, P. M. P. V. B. E., & Stanimirovic, D. B. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03463.x · Cited by 216 · see citing works

Transport Across the Primate Blood-Brain Barrier of a Genetically Engineered Chimeric Monoclonal Antibody to the Human Insulin Receptor

Coloma, M. J., Lee, H., Kurihara, A., Landaw, E. M., Boado, R. J., Morrison, S. L., & Pardridge, W. M. (2000) · Pharmaceutical Research · doi:10.1023/a:1007592720793 · Cited by 207 · see citing works

Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson’s disease treatment

Bi, C., Wang, A., Chu, Y., Liu, S., Mu, H., Liu, W., Wu, Z., Sun, K., & Li, Y. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s120939 · Cited by 203 · see citing works

Will the original glucose transporter isoform please stand up!

Carruthers, A., Zutter, J. K. D., Ganguly, A., & Devaskar, S. U. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00496.2009 · Cited by 202 · see citing works

Decreased transport of leptin across the blood–brain barrier in rats lacking the short form of the leptin receptor☆

Kastin, A. J., Pan, W., Maness, L. M., Koletsky, R. J., & Ernsberger, P. R. (1999) · Peptides · doi:10.1016/s0196-9781(99)00156-4 · Cited by 199 · see citing works

Temozolomide in malignant gliomas: current use and future targets

Villano, J. L., Seery, T. E., & Bressler, L. R. (2009) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-009-1050-5 · Cited by 198 · see citing works

Clinical Evidence Supporting Early Treatment Of Patients With Spinal Muscular Atrophy: Current Perspectives

Dangouloff, T., & Servais, L. (2019) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s172291 · Cited by 198 · see citing works

Tissue Plasminogen Activator (tPA) and Matrix Metalloproteinases in the Pathogenesis of Stroke: Therapeutic Strategies

Rao, A. M., & Hatcher, J. F. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708784936608 · Cited by 196 · see citing works

Co-delivery of doxorubicin and erlotinib through liposomal nanoparticles for glioblastoma tumor regression using an in vitro brain tumor model

Lakkadwala, S., & Singh, J. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.09.047 · Cited by 194 · see citing works

Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice

Liu, Y., An, S., Li, J., Kuang, Y., He, X., Guo, Y., Ma, H., Zhang, Y., Ji, B., & Jiang, C. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.060 · Cited by 190 · see citing works

Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain

van Rooy, I., Mastrobattista, E., Storm, G., Hennink, W. E., & Schiffelers, R. M. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.014 · Cited by 188 · see citing works

Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat

Cheng, D., Cao, N., Chen, J., Yu, X., & Shuai, X. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.057 · Cited by 184 · see citing works

Frontotemporal dementia: latest evidence and clinical implications

Young, J. J., Lavakumar, M., Tampi, D. J., Balachandran, S., & Tampi, R. R. (2017) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125317739818 · Cited by 183 · see citing works

Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review

Li, J., Zhao, J., Tan, T., Liu, M., Zeng, Z., Zeng, Y., Zhang, L., Fu, C., Chen, D., & Xie, T. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s243223 · Cited by 182 · see citing works

Site-Specific, Sustained Release of Drugs to the Brain

Bodor, N. S., Farag, H. H. A., & Brewster, M. E. (1981) · Science · doi:10.1126/science.7313698 · Cited by 181 · see citing works

A D ‐Peptide Ligand of Nicotine Acetylcholine Receptors for Brain‐Targeted Drug Delivery

Wei, X., Zhan, C., Shen, Q., Fu, W., Xie, C., Gao, J., Peng, C., Zheng, P., & Lu, W. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201411226 · Cited by 181 · see citing works

Efflux transport systems for drugs at the blood–brain barrier and blood–cerebrospinal fluid barrier (Part 1)

Kusuhara, H., & Sugiyama, Y. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(00)01632-9 · Cited by 177 · see citing works

Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-β in Lewis rats

Yang, J.-S., Xu, L., Xiao, B., Hedlund, G., & Link, H. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.02.016 · Cited by 175 · see citing works

Nanotechnology for neurodegenerative disorders

Re, F., Gregori, M., & Masserini, M. (2012) · Maturitas · doi:10.1016/j.maturitas.2011.12.015 · Cited by 174 · see citing works

Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (bbb).

Kreuter, J. (2013) · Journal of Microencapsulation · doi:10.3109/02652048.2012.692491 · Cited by 172 · see citing works

Biopharmaceutical drug targeting to the brain

Pardridge, W. M. (2010) · Journal of drug targeting · doi:10.3109/10611860903548354 · Cited by 172 · see citing works

A leptin derived 30-amino-acid peptide modified pegylated poly-l-lysine dendrigraft for brain targeted gene delivery

Liu, Y., Li, J., Shao, K., Huang, R., Ye, L., Lou, J., & Jiang, C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.011 · Cited by 172 · see citing works

Tolcapone improves motor function in parkinsonian patients with the"wearing-off" phenomenon: A double-blind, placebo-controlled, multicenter trial

Rajput, A. H., Martin, W. R. W., Saint‐Hilaire, M., Dorflinger, E. E., & Pedder, S. C. J. (1997) · Neurology · doi:10.1212/wnl.49.4.1066 · Cited by 168 · see citing works

Overcoming blood brain barrier with a dual purpose Temozolomide loaded Lactoferrin nanoparticles for combating glioma (SERP-17-12433)

Kumari, S., Saad, M. A., Kumar, J. M., Kondapi, A. K., & Rao, N. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-06888-4 · Cited by 164 · see citing works

Herbal Drugs: Ethnomedicine to Modern Medicine

Ramawat, K. G. (2008) · Springer eBooks · doi:10.1007/978-3-540-79116-4 · Cited by 164 · see citing works

Glial influences on BBB functions and molecular players in immune cell trafficking

Lécuyer, M., Kébir, H., & Prat, A. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.004 · Cited by 163 · see citing works

Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier

Pan, W., Kastin, A. J., Zankel, T. R., van Kerkhof, P., Terasaki, T., & Bu, G. (2004) · Journal of Cell Science · doi:10.1242/jcs.01381 · Cited by 153 · see citing works

Drug targeting with nanoparticles

Kreuter, J. (1994) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03188928 · Cited by 153 · see citing works

Micelle‐Based Brain‐Targeted Drug Delivery Enabled by a Nicotine Acetylcholine Receptor Ligand

Zhan, C., Li, B., Hu, L., Wei, X., Feng, L., Fu, W., & Lu, W. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201100875 · Cited by 152 · see citing works

Delivery of Biologics Across the Blood–Brain Barrier with Molecular Trojan Horse Technology

Pardridge, W. M. (2017) · BioDrugs · doi:10.1007/s40259-017-0248-z · Cited by 152 · see citing works

Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a

Tiwary, S., Morales, J. E., Kwiatkowski, S. C., Lang, F. F., Rao, G., & McCarty, J. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-26636-6 · Cited by 150 · see citing works

Mobile phone radiation causes brain tumors and should be classified as a probable human carcinogen (2A) (Review)

Morgan, L. L., Miller, A. B., Sasco, A. J., & Davis, D. L. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.2908 · Cited by 150 · see citing works

Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL‐associated vitamin E

Goti, D., Hrzenjak, A., Levak‐Frank, S., Frank, S., van der Westhuyzen, D. R., Malle, E., & Sattler, W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00100.x · Cited by 149 · see citing works

A brain targeting functionalized liposomes of the dopamine derivative N -3,4-bis(pivaloyloxy)-dopamine for treatment of Parkinson's disease

Qu, M., Lin, Q., He, S., Wang, L., Fu, Y. S., Zhang, Z., & Zhang, L. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.03.019 · Cited by 138 · see citing works

Brain tumor-targeted therapy by systemic delivery of siRNA with Transferrin receptor-mediated core-shell nanoparticles

Wei, L., Guo, X., Yang, T., Yu, M., Chen, D., & Wang, J. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.06.127 · Cited by 133 · see citing works

Tolcapone improves motor function in parkinsonian patients with the"wearing-off" phenomenon

Rajput, A. H., Martin, W. R. W., Saint‐Hilaire, M., Dorflinger, E. E., & Pedder, S. C. J. (1998) · Neurology · doi:10.1212/wnl.50.5_suppl_5.s54 · Cited by 132 · see citing works

Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology

Moura, R. P., Martins, C., Pinto, S. F. T., Sousa, F., & Sarmento, B. F. C. C. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1583205 · Cited by 127 · see citing works

Astrocytes Integrate Behavioral State and Vascular Signals during Functional Hyperemia

Tran, C. H. T., Peringod, G., & Gordon, G. R. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.045 · Cited by 126 · see citing works

Efficacy of interleukin-13 receptor–targeted liposomal doxorubicin in the intracranial brain tumor model

Madhankumar, A. B., Slagle‐Webb, B., Wang, X., Yang, Q. X., Antonetti, D. A., Miller, P. A., Sheehan, J. M., & Connor, J. R. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0853 · Cited by 124 · see citing works

Precision Nanomedicine in Neurodegenerative Diseases

Goldsmith, M., Abramovitz, L., & Peer, D. (2014) · ACS Nano · doi:10.1021/nn501292z · Cited by 124 · see citing works

Role of Epigenetics in Alzheimer ‘S and Parkinson‘S Disease

Kwok, J. B. (2010) · Epigenomics · doi:10.2217/epi.10.43 · Cited by 119 · see citing works

Correction: Corrigendum: The Phosphorylation Profile of Myosin Binding Protein-C Slow is Dynamically Regulated in Slow-Twitch Muscles in Health and Disease

Ackermann, M. A., Kerr, J. P., King, B., Ward, C. W., & Kontrogianni‐Konstantopoulos, A. (2018) · Scientific Reports · doi:10.1038/srep46969 · Cited by 116 · see citing works

Challenges in drug delivery to tumors of the central nervous system: An overview of pharmacological and surgical considerations

Serwer, L., & James, C. D. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.004 · Cited by 114 · see citing works

HMG-CoA reductase inhibitor therapy and stroke risk reduction: an analysis of clinical trials data

Crouse, J. R., Byington, R. P., & Furberg, C. D. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00014-8 · Cited by 111 · see citing works

Co-delivery of TRAIL gene enhances the anti-glioblastoma effect of paclitaxel in vitro and in vivo

Zhan, C., Wei, X., Qian, J., Feng, L., Zhu, J., & Lu, W. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.02.022 · Cited by 110 · see citing works

Delivery of β-Galactosidase to Mouse Brain via the Blood-Brain Barrier Transferrin Receptor

Zhang, Y., & Pardridge, W. M. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.082974 · Cited by 110 · see citing works

Therapeutic and Diagnostic Applications of Nanoparticles

Youns, M., Hoheisel, J. D., & Efferth, T. (2011) · Current Drug Targets · doi:10.2174/138945011794815257 · Cited by 107 · see citing works

Role of P‐Glycoprotein in the Blood‐Brain Transport of Colchicine and Vinblastine

Drion, N., Lemaire, M., Lefauconnier, J.-M., & Scherrmann, J. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67041688.x · Cited by 104 · see citing works

A novel doxorubicin loaded folic acid conjugated PAMAM modified with borneol, a nature dual-functional product of reducing PAMAM toxicity and boosting BBB penetration

Xu, X., Li, J., Han, S., Tao, C., Fang, L., Sun, Y., Zhu, J., Liang, Z., & Li, F. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.02.015 · Cited by 102 · see citing works

Self-Assembly of Gold Nanoparticles Shows Microenvironment-Mediated Dynamic Switching and Enhanced Brain Tumor Targeting

Feng, Q., Shen, Y., Fu, Y., Muroski, M. E., Zhang, P., Wang, Q., Xu, C., Lesniak, M. S., Li, G., & Cheng, Y. (2017) · Theranostics · doi:10.7150/thno.18985 · Cited by 99 · see citing works

Differential receptor-mediated drug targeting to the diseased brain

Rip, J., Schenk, G., & de Boer, A. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240902806383 · Cited by 98 · see citing works

Designing the nanobiointerface of fluorescent nanodiamonds: highly selective targeting of glioma cancer cells

Šlegerová, J., Hajek, M., Řehoř, I., Sedlák, F., Štursa, J., Hrubý, M., & Cígler, P. (2014) · Nanoscale · doi:10.1039/c4nr02776k · Cited by 97 · see citing works

Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients

Chan, A., Weilbach, F. X., Toyka, K. V., & Gold, R. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02653.x · Cited by 97 · see citing works

Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model

Juthani, R. G., Madajewski, B., Yoo, B., Zhang, L., Chen, P.-M., Chen, F., Turker, M. Z., Ma, K., Overholtzer, M., Longo, V. A., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1834 · Cited by 96 · see citing works

CA1-specific N -methyl- d -aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task

Rondi‐Reig, L., Libbey, M., Eichenbaum, H., & Tonegawa, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041620798 · Cited by 92 · see citing works

Risk of Brain Tumor Induction from Pediatric Head CT Procedures: A Systematic Literature Review

Sheppard, J. P., Nguyen, T., Alkhalid, Y., Beckett, J. S., Salamon, N., & Yang, I. (2018) · Brain Tumor Research and Treatment · doi:10.14791/btrt.2018.6.e4 · Cited by 90 · see citing works

The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier

Boado, R. J., & Pardridge, W. M. (2011) · Journal of Drug Delivery · doi:10.1155/2011/296151 · Cited by 83 · see citing works

Comparative Physiology of the Blood-Brain Barrier

Abbott, N. J. (1992) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-76894-1_15 · Cited by 83 · see citing works

Diphtheria toxin receptor-targeted brain drug delivery

Gaillard, P. J., Brink, A., & de Boer, A. G. (2005) · International Congress Series · doi:10.1016/j.ics.2005.02.022 · Cited by 79 · see citing works

Modulation of transferrin receptor expression and function by anti-transferrin receptor antibodies and antibody fragments

Lesley, J., Schulte, R. J., & Woods, J. W. (1989) · Experimental Cell Research · doi:10.1016/0014-4827(89)90293-0 · Cited by 77 · see citing works

The ABC of the Blood-Brain Barrier - Regulation of Drug Efflux Pumps

Mahringer, A., Ott, M., Reimold, I., Reichel, V., & Fricker, G. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211797440221 · Cited by 72 · see citing works

In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes

Candela, P., Saint‐Pol, J., Kuntz, M., Boucau, M., Lamartinière, Y., Gosselet, F., & Fénart, L. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.047 · Cited by 71 · see citing works

Biodistribution of TAT or QLPVM coupled to receptor targeted liposomes for delivery of anticancer therapeutics to brain in vitro and in vivo

Lakkadwala, S., Rodrigues, B. D. S., Sun, C., & Singh, J. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102112 · Cited by 71 · see citing works

Treatment of Invasive Brain Tumors Using a Chain-like Nanoparticle

Peiris, P. M., Abramowski, A., Mcginnity, J., Doolittle, E., Toy, R., Gopalakrishnan, R., Shah, S., Bauer, L., Ghaghada, K. B., Hoimes, C. J., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-1540 · Cited by 69 · see citing works

Lactoferrin-modified nanoparticles could mediate efficient gene delivery to the brain in vivo

Huang, R., Ke, W., Han, L., Liu, Y., Shao, K., Jiang, C., & Pei, Y. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.12.008 · Cited by 69 · see citing works

Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases

Bélanger, K., Iqbal, U. H., Tanha, J., MacKenzie, R., Moreno, M., & Stanimirovic, D. B. (2019) · Antibodies · doi:10.3390/antib8020027 · Cited by 69 · see citing works

O2 exchange between blood and brain tissues studied with 18O2 indicator-dilution technique

Grieb, P., Forster, R. E., Strome, D. R., Goodwin, C. W., & Pape, P. C. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.58.6.1929 · Cited by 68 · see citing works

Loop 2 of Ophiophagus hannah Toxin b Binds with Neuronal Nicotinic Acetylcholine Receptors and Enhances Intracranial Drug Delivery

Zhan, C., Yan, Z., Xie, C., & Lu, W. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100238j · Cited by 68 · see citing works

Brain Targeted Drug Delivery System

(2018) · Elsevier eBooks · doi:10.1016/c2017-0-00836-4 · Cited by 62 · see citing works

Leptin-derived peptide, a targeting ligand for mouse brain-derived endothelial cells via macropinocytosis

Tamaru, M., Akita, H., Fujiwara, T., Kajimoto, K., & Harashima, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.024 · Cited by 61 · see citing works

Solid lipid nanoparticles carrying chemotherapeutic drug across the blood–brain barrier through insulin receptor-mediated pathway

Kuo, Y., & Shih-Huang, C.-Y. (2013) · Journal of drug targeting · doi:10.3109/1061186x.2013.812094 · Cited by 59 · see citing works

Perspectives on brain-targeting drug delivery systems.

Guo, L., Ren, J., & Jiang, X. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112803341770 · Cited by 57 · see citing works

Immunocytochemical distribution of transferrin and its receptor in the developing chicken nervous system

Oh, T. H., Markelonis, G. J., ROYAL, G., & Bregman, B. S. (1986) · Developmental Brain Research · doi:10.1016/0165-3806(86)90111-2 · Cited by 57 · see citing works

Bifunctional Aptamer–Doxorubicin Conjugate Crosses the Blood–Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells

MacDonald, J. P., Denoyer, D., Henri, J., Jamieson, A., Burvenich, I. J. G., Pouliot, N., & Shigdar, S. L. (2020) · Nucleic Acid Therapeutics · doi:10.1089/nat.2019.0807 · Cited by 56 · see citing works

Brain aging and Parkinson’s disease: New therapeutic approaches using drug delivery systems

Rodríguez‐Nogales, C., Garbayo, E., Carmona‐Abellán, M., Luquín, M. R., & Blanco‐Prieto, M. J. (2015) · Maturitas · doi:10.1016/j.maturitas.2015.11.009 · Cited by 54 · see citing works

Synthetic Polymer Nanoparticles Functionalized with Different Ligands for Receptor-Mediated Transcytosis across the Blood–Brain Barrier

Lu, Q., Cai, X., Zhang, X., Li, S., Song, Y., Du, D., Dutta, P., & Lin, Y. (2018) · ACS Applied Bio Materials · doi:10.1021/acsabm.8b00502 · Cited by 54 · see citing works

A polymeric temozolomide nanocomposite against orthotopic glioblastoma xenograft: tumor-specific homing directed by nestin

Prabhu, S., Goda, J. S., Mutalik, S., Mohanty, B. S., Chaudhari, P., Rai, S., Udupa, N., & Rao, B. S. S. (2017) · Nanoscale · doi:10.1039/c7nr00305f · Cited by 54 · see citing works

Can Leptin-Derived Sequence-Modified Nanoparticles Be Suitable Tools for Brain Delivery?

Tosi, G., Badiali, L., Ruozi, B., Vergoni, A. V., Bondioli, L., Ferrari, A., Rivasi, F., Forni, F., & Vandelli, M. A. (2011) · Nanomedicine · doi:10.2217/nnm.11.98 · Cited by 52 · see citing works

Comparison of CRM197, diphtheria toxoid and tetanus toxoid as protein carriers for meningococcal glycoconjugate vaccines

Tontini, M., Berti, F., Romano, M. R., Proietti, D., Zambonelli, C., Bottomley, M. J., Gregorio, E. D., Giudice, G. D., Rappuoli, R., Costantino, P., et al. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.07.078 · Cited by 52 · see citing works

Clinical presentation and epidemiology of brain tumors firstly diagnosed in adults in the Emergency Department: a 10-year, single center retrospective study

Comelli, I., Lippi, G., Campana, V., Servadei, F., & Cervellin, G. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.06.12 · Cited by 52 · see citing works

Targeted brain delivery of itraconazole via RVG29 anchored nanoparticles

Chen, W., Zhan, C., Gu, B., Meng, Q., Wang, H., Lu, W., & Hou, H. (2010) · Journal of drug targeting · doi:10.3109/1061186x.2010.492523 · Cited by 51 · see citing works

Diphtheria Toxin Mutant CRM197-Mediated Transcytosis across Blood–Brain Barrier In Vitro

Wang, P., Xue, Y., Shang, X., & Liu, Y. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9496-x · Cited by 49 · see citing works

Dual targeting of folate receptor-expressing glioma tumor-associated macrophages and epithelial cells in the brain using a carbon nanosphere–cationic folate nanoconjugate

Elechalawar, C. K., Bhattacharya, D., Ahmed, M. T., Ravuri, H. G., Sridharan, K., Chaturbedy, P., Sinha, S. H., Jaggarapu, M. M. C. S., Narayan, K. P., Chakravarty, S., et al. (2019) · Nanoscale Advances · doi:10.1039/c9na00056a · Cited by 48 · see citing works

Exploiting Bacterial Pathways for BBB Crossing with PLGA Nanoparticles Modified with a Mutated Form of Diphtheria Toxin (CRM197):In VivoExperiments

Tosi, G., Vilella, A., Veratti, P., Belletti, D., Pederzoli, F., Ruozi, B., Vandelli, M. A., Zoli, M., & Forni, F. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00446 · Cited by 48 · see citing works

A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model

Thom, G., Tian, M.-M., Hatcher, J. P., Melero, N. R., Burrell, M. R., Gurrell, I. K., Vitalis, T. Z., Abraham, T., Jefferies, W. A., Webster, C. I., et al. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18772998 · Cited by 47 · see citing works

Delivery of Temozolomide and N3-Propargyl Analog to Brain Tumors Using an Apoferritin Nanocage

Bouzinab, K., Summers, H. S., Stevens, M. F. G., Moody, C. J., Thomas, N. R., Gershkovich, P., Weston, N., Ashford, M. B., Bradshaw, T. D., & Turyanska, L. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c01514 · Cited by 47 · see citing works

Tumor cell targeted delivery by specific peptide-modified mesoporous silica nanoparticles

Wang, Y., Shi, W., Song, W., Wang, L., Liu, X., Chen, J., & Huang, R. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm32398b · Cited by 46 · see citing works

Development of a potential protein vector (NeuroTrans) to deliver drugs across the blood–brain barrier

Gabathuler, R., Arthur, G., Kennard, M. L., Chen, Q., Tsai, S., Yang, J., Schoorl, W., Vitalis, T., & Jefferies, W. A. (2005) · International Congress Series · doi:10.1016/j.ics.2005.02.021 · Cited by 46 · see citing works

Folate Receptor α-Modified Nanoparticles for Targeting of the Central Nervous System

Kuplennik, N., Lang, K., Steinfeld, R., & Sosnik, A. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b14659 · Cited by 45 · see citing works

Heparin-Binding Epidermal Growth Factor-like Growth Factor/Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis

Vinante, F., & Rigo, A. (2013) · Toxins · doi:10.3390/toxins5061180 · Cited by 43 · see citing works

Structure-function relationships of curaremimetic neurotoxin loop 2 and of a structurally similar segment of rabies virus glycoprotein in their interaction with the nicotinic acetylcholine receptor

Lentz, T. L. (1991) · Biochemistry · doi:10.1021/bi00109a020 · Cited by 41 · see citing works

CRM197-Induced Blood–Brain Barrier Permeability Increase is Mediated by Upregulation of Caveolin-1 Protein

Wang, P., Liu, Y., Shang, X., & Xue, Y. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9471-5 · Cited by 35 · see citing works

New non-oral drug delivery systems for Parkinson's disease treatment

Md, S., Haque, S., Sahni, J. K., Baboota, S., & Ali, J. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.556616 · Cited by 33 · see citing works

Phage display as a tool to discover blood–brain barrier ( BBB )‐shuttle peptides: panning against a human BBB cellular model

Díaz‐Perlas, C., Sánchez‐Navarro, M., Oller‐Salvia, B., Moreno, M. R., Teixidò, M., & Giralt, E. (2016) · Biopolymers · doi:10.1002/bip.22928 · Cited by 33 · see citing works

Physiology of the Blood–Brain Barrier and Mechanisms of Transport Across the BBB

Lalatsa, A., & Butt, A. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812218-1.00003-8 · Cited by 31 · see citing works

The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis—Therapeutic Opportunities in Hemolytic Conditions

Kristiansson, A., Gram, M., Flygare, J., Hansson, S. R., Åkerström, B., & Storry, J. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197234 · Cited by 31 · see citing works

Drug treatment of Parkinson's disease

Korczyn, A. D. (2004) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2004.6.3/akorczyn · Cited by 31 · see citing works

The SR-B1 Receptor as a Potential Target for Treating Glioblastoma

Berney, E., Sabnis, N. A., Panchoo, M., Raut, S., Dickerman, R. D., & Lacko, A. G. (2019) · Journal of Oncology · doi:10.1155/2019/1805841 · Cited by 30 · see citing works

Duodopa pump treatment in patients with advanced Parkinson's disease.

Karlsborg, M., Korbo, L., Regeur, L., & Glad, A. (2010) · PubMed · Cited by 30 · see citing works

Nicotinic acetylcholine receptors

Wonnacott, S., Bermúdez, I., Millar, N. S., & Tzartos, S. J. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14209 · Cited by 30 · see citing works

2B-Trans™ Technology: Targeted Drug Delivery Across the Blood-Brain Barrier

Gaillard, P. J., & de Boer, A. G. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-210-6_8 · Cited by 28 · see citing works

Overcoming the blood–brain barrier for glioma-targeted therapy based on an interleukin-6 receptor-mediated micelle system

Shi, W., Cui, X., Shi, J., Chen, J., & Wang, Y. (2017) · RSC Advances · doi:10.1039/c7ra03208k · Cited by 27 · see citing works

Application of dual targeting drug delivery system for the improvement of anti-glioma efficacy of doxorubicin

Sun, Z., Yan, X., Liu, Y., Huang, L., Kong, C., Qu, X., Wang, M., Gao, R., & Qin, H. (2017) · Oncotarget · doi:10.18632/oncotarget.19221 · Cited by 27 · see citing works

Recombinant expressing angiopep-2 fused anti-VEGF single chain Fab (scFab) could cross blood–brain barrier and target glioma

Ji, X., Wang, H., Chen, Y., Zhou, J., & Liu, Y. (2019) · AMB Express · doi:10.1186/s13568-019-0869-3 · Cited by 25 · see citing works

Cardiolipin-incorporated liposomes with surface CRM197 for enhancing neuronal survival against neurotoxicity

Kuo, Y., & Liu, Y. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.07.003 · Cited by 21 · see citing works

Insulin-coated gold nanoparticles as an effective approach for bypassing the blood-brain barrier

Betzer, O., Shilo, M., Motiei, M., & Popovtzer, R. (2019) · Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications · doi:10.1117/12.2510353 · Cited by 21 · see citing works

Allosterism of Nicotinic Acetylcholine Receptors: Therapeutic Potential for Neuroinflammation Underlying Brain Trauma and Degenerative Disorders

Mitra, S., Khatri, S., Maulik, M., Bult‐Ito, A., & Schulte, M. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144918 · Cited by 20 · see citing works

Targeting the Inflammatory Response in Secondary Stroke Prevention: A Role for Combining Aspirin and Extended-release Dipyridamole

Weyrich, A. S., Skalabrin, E. J., & Kraiss, L. W. (2009) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31814b17bf · Cited by 18 · see citing works

Use of a Noninvasive Brain-Penetrating Peptide-Drug Conjugate Strategy to Improve the Delivery of Opioid Pain Relief Medications to the Brain

Eiselt, É., Otis, V., Belleville, K., Yang, G., Larocque, A., Régina, A., Demeule, M., Sarret, P., & Gendron, L. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.263566 · Cited by 18 · see citing works

Brain Drug Targeting: The Future of Brain Drug Development.: Pardridge W M. Cambridge University Press, 2001, 65.00. ISBN 0 521 80077 3

Kamphorst, W., de Boer, A. G., & Gaillard, P. J. (2002) · Journal of Clinical Pathology · doi:10.1136/jcp.55.2.158-a · Cited by 14 · see citing works

Receptor-mediated transportation through BBB

Zhang, Z., & Zhan, C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814001-7.00005-6 · Cited by 14 · see citing works

Novel Leads from Herbal Drugs for Neurodegenerative Diseases

Bhatnagar, M. (2008) · Springer eBooks · doi:10.1007/978-3-540-79116-4_14 · Cited by 12 · see citing works

Single domain antibodies as blood–brain barrier delivery vectors

Abulrob, A., Zhang, J., Tanha, J., MacKenzie, R., & Stanimirovic, D. B. (2005) · International Congress Series · doi:10.1016/j.ics.2005.02.024 · Cited by 12 · see citing works

The blood–brain barrier: Structure, regulation and drug delivery

Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906 · see citing works

Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain through BBB

Satapathy, M. K., Yen, T.-L., Jan, J.-S., Tang, R.-D., Wang, J.-Y., Taliyan, R., & Yang, C.-H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081183 · Cited by 318 · see citing works

Drug Delivery Challenges in Brain Disorders across the Blood–Brain Barrier: Novel Methods and Future Considerations for Improved Therapy

Achar, A., Westcott, R., & Ghosh, C. (2021) · Biomedicines · doi:10.3390/biomedicines9121834 · Cited by 191 · see citing works

Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

Mitusova, K. A., Peltek, O. O., Karpov, T. E., Muslimov, A. R., Zyuzin, M. V., & Timin, A. S. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01610-7 · Cited by 186 · see citing works

Precision-engineered metal and metal-oxide nanoparticles for biomedical imaging and healthcare applications

Truong, T. T., Mondal, S. A., Doan, V. H. M., Tak, S., Choi, J., Oh, H., Nguyen, T. D., Misra, M., Lee, B., & Oh, J. (2024) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2024.103263 · Cited by 190 · see citing works

Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Zhang, L., Liu, Y., Huang, H., Xie, H., Zhang, B., Xia, W., & Guo, B. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114536 · Cited by 177 · see citing works

Surface-modified lipid nanocarriers for crossing the blood-brain barrier (BBB): A current overview of active targeting in brain diseases

Teixeira, M. I., Lopes, C. M., Amaral, M. H., & Costa, P. C. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.112999 · Cited by 155 · see citing works

Non-Invasive Drug Delivery across the Blood–Brain Barrier: A Prospective Analysis

Niazi, S. K. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112599 · Cited by 147 · see citing works

Advanced liposome and polymersome-based drug delivery systems: Considerations for physicochemical properties, targeting strategies and stimuli-sensitive approaches

Kansız, S., & Elçin, Y. M. (2023) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2023.102930 · Cited by 131 · see citing works

Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain

Wu, J. R., Hernández, Y. M., Miyasaki, K. F., & Kwon, E. J. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114820 · Cited by 103 · see citing works

Peptides as Pharmacological Carriers to the Brain: Promises, Shortcomings and Challenges

Parrasia, S., Szabó, I., Zoratti, M., & Biasutto, L. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00523 · Cited by 90 · see citing works

Advancements in Nanoemulsion-Based Drug Delivery Across Different Administration Routes

Chatzidaki, M. D., & Mitsou, E. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030337 · Cited by 74 · see citing works

Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management

Pei, J., Kumarasamy, R. V., Jayaraman, S., Kanniappan, G. V., Long, Q., & Palanisamy, C. P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102665 · Cited by 66 · see citing works

Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics

Markowicz-Piasecka, M., Markiewicz, A., Darłak, P., Sikora, J., Adla, S. K., Bagina, S., & Huttunen, K. M. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01228-5 · Cited by 68 · see citing works

Drug Delivery Across the Blood–Brain Barrier: A New Strategy for the Treatment of Neurological Diseases

Jiao, Y., Yang, L., Wang, R., Song, G., Fu, J., Wang, J., Gao, N., & Wang, H. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16121611 · Cited by 63 · see citing works

Engineered Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as New Generations of Blood–Brain Barrier Transmitters

Amiri, M., Jafari, S., Kurd, M., Mohamadpour, H., Khayati, M., Ghobadinezhad, F., Tavallaei, O., Derakhshankhah, H., Malvajerd, S. S., & Izadi, Z. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00540 · Cited by 61 · see citing works

Advancing neurological disorders therapies: Organic nanoparticles as a key to blood-brain barrier penetration

Razavi, Z. S., Alizadeh, S. S., Razavi, F. S., Souri, M., & Soltani, M. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125186 · Cited by 58 · see citing works

Targetability of the neurovascular unit in inflammatory diseases of the central nervous system

Smith, B. C., Tinkey, R. A., Shaw, B. C., & Williams, J. L. (2022) · Immunological Reviews · doi:10.1111/imr.13121 · Cited by 53 · see citing works

Transport of nanomedicines across the blood-brain barrier: Challenges and opportunities for imaging and therapy

van den Broek, S. L., Shalgunov, V., & Herth, M. M. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213125 · Cited by 53 · see citing works

Advances in nanotechnology versus stem cell therapy for the theranostics of Huntington's disease

Channa, G. M., Hassan, D., Zeeshan, M., Ruiz-Pulido, G., Ebrahimi, N., Mobashar, A., Pourmadadi, M., Rahdar, A., Sargazi, S., Fathi‐karkan, S., et al. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104774 · Cited by 53 · see citing works

Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier

Wei, Y., Xia, X., Li, H., & Gao, H. (2023) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2023.2245332 · Cited by 50 · see citing works

Brain-targeting drug delivery systems.

Liu, P.-X., & Jiang, C. (2022) · Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1818 · Cited by 40 · see citing works

Current Update on Transcellular Brain Drug Delivery

Pawar, B., Vasdev, N., Gupta, T., Mhatre, M., More, A., Anup, N., & Tekade, R. K. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122719 · Cited by 44 · see citing works

Transferrin-Enabled Blood–Brain Barrier Crossing Manganese-Based Nanozyme for Rebalancing the Reactive Oxygen Species Level in Ischemic Stroke

Zhao, Q., Du, W., Zhou, L., Wu, J., Zhang, X., Wei, X., Wang, S., Huang, Y., & Li, Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061122 · Cited by 43 · see citing works

Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease

Долгачева, Л. П., Зинченко, В. П., & Goncharov, N. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113043 · Cited by 41 · see citing works

A new frontier in neuropharmacology: Recent progress in natural products research for blood–brain barrier crossing

Ureña-Vacas, I., Belén, A. D. L. R. M., Serrano, D. R., & González‐Burgos, E. (2024) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2024.100235 · Cited by 41 · see citing works

Nanosystems for targeted drug Delivery: Innovations and challenges in overcoming the Blood-Brain barrier for neurodegenerative disease and cancer therapy

Rafati, N., Zarepour, A., Bigham, A., Khosravi, A., Naderi‐Manesh, H., Iravani, S., & Zarrabi, A. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124800 · Cited by 42 · see citing works

Advancing Brain Targeting: Cost-Effective Surface-Modified Nanoparticles for Faster Market Entry

Gomes, M., Ramalho, M. J., Loureiro, J. A., & Pereira, M. D. C. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17050661 · Cited by 38 · see citing works

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Ju, Y., Liu, X., Ye, X., Dai, M., Fang, B., Shen, X., & Liu, L. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c02097 · Cited by 34 · see citing works

Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases

Jiménez, A., Estudillo, E., Guzmán‐Ruiz, M. A., Herrera, N., Victoria-Acosta, G., Cortés-Malagón, E. M., & López-Ornelas, A. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030281 · Cited by 34 · see citing works

Influence of Surface Ligand Density and Particle Size on the Penetration of the Blood–Brain Barrier by Porous Silicon Nanoparticles

Zhang, W., Zhu, D., Tong, Z., Peng, B., Cheng, X., Esser, L., & Voelcker, N. H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092271 · Cited by 32 · see citing works

Ligands for oral delivery of peptides across the blood-brain-barrier

Gailani, M. A., Liu, M., & Wen, J. (2022) · Acta Materia Medica · doi:10.15212/amm-2021-0007 · Cited by 32 · see citing works

Solid Lipid Nanoparticles (SLNs): Advancements in Modification Strategies Toward Drug Delivery Vehicle

Alsayadi, G. M. H., Verma, A., Choudhary, Y. V., Sandal, P., Patel, P., Singh, D., Gupta, G. D., & Kurmi, B. D. (2022) · Pharmaceutical Nanotechnology · doi:10.2174/2211738511666221026163303 · Cited by 29 · see citing works

Non-Invasive Techniques of Nose to Brain Delivery Using Nanoparticulate Carriers: Hopes and Hurdles

Butola, M., & Nainwal, N. (2024) · AAPS PharmSciTech · doi:10.1208/s12249-024-02946-z · Cited by 28 · see citing works

Microenvironments‐Modulated Biomaterials Enhance Spinal Cord Injury Therapy

Li, Y., Zhang, Q., Liu, Z., Fu, C., & Ding, J. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202403900 · Cited by 25 · see citing works

Nano-Innovations in Cancer Therapy: The Unparalleled Potential of MXene Conjugates

Kulkarni, S., Soman, S., Navti, P. D., Roy, A. A., Nikam, A. N., Vineeth, P., Kulkarni, J., Shirur, K. S., Pandey, A. P., George, S. D., et al. (2024) · Materials · doi:10.3390/ma17061423 · Cited by 24 · see citing works

Pretargeted Imaging beyond the Blood–Brain Barrier—Utopia or Feasible?

van den Broek, S. L., Shalgunov, V., Vázquez, R. G., Beschörner, N., Bidesi, N., Nedergaard, M., Knudsen, G. M., Sehlin, D., Syvänen, S., & Herth, M. M. (2022) · Pharmaceuticals · doi:10.3390/ph15101191 · Cited by 24 · see citing works

Advanced nanoparticle engineering for precision therapeutics of brain diseases

Ismail, M., Liu, J., Wang, N., Zhang, D., Qin, C., Shi, B., & Zheng, M. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123138 · Cited by 23 · see citing works

Stem Cell-derived Extracellular Vesicles: A Promising Nano Delivery Platform to the Brain?

Guo, Y., Hu, D., Lian, L., Zhao, L., Li, M., Bao, H., & Xu, S. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10455-4 · Cited by 23 · see citing works

Brain-targeting redox-sensitive micelles for codelivery of TMZ and β-lapachone for glioblastoma therapy

Dai, Y., Min, Y., Lu, Z., Cheng, L., Ni, H., Yang, Y., & Zhou, W. (2024) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2024.102772 · Cited by 20 · see citing works

Benzo[b]fluoranthene (B[b]F) affects apoptosis, oxidative stress, mitochondrial membrane potential and expressions of blood-brain barrier markers in microvascular endothelial cells

Zhao, S., Bao, Q., Ma, G., Yao, Y., Xie, L., & Xiong, J. (2022) · Toxicology in Vitro · doi:10.1016/j.tiv.2022.105522 · Cited by 19 · see citing works

ROS Regulation in CNS Disorder Therapy: Unveiling the Dual Roles of Nanomedicine

Quan, Z., Wang, S., Xie, H., Zhang, J., Duan, R., Li, M., & Zhang, J. (2024) · Small · doi:10.1002/smll.202410031 · Cited by 18 · see citing works

Neurotherapeutics across blood–brain barrier: screening of BBB-permeable and CNS-active molecules for neurodegenerative disease

Kumar, D. M., & Talwar, P. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1616144 · Cited by 18 · see citing works

Potential applications of mesoporous silica nanoparticles for the treatment of neurological disorders

Bhatane, D., Pamshong, S. R., Sarnaik, S., Prabakaran, A., & Alexander, A. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104970 · Cited by 17 · see citing works

Comprehensive Analysis of Mouse Hippocampal Lysine Acetylome Mediated by Sea Cucumber Peptides Preventing Memory Impairment

Lu, Z., Xu, X., Li, D., Sun, N., & Lin, S. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05155 · Cited by 18 · see citing works

Overcoming the Blood-Brain Barrier for Drug Delivery to the Brain

Katz, J. S., Slika, H., Sattari, S. A., Malla, A. P., Xia, Y., Antar, A., Ran, K. R., & Tyler, B. (2025) · ACS Omega · doi:10.1021/acsomega.5c00364 · Cited by 17 · see citing works

Folic-Acid-Conjugated Poly (Lactic-Co-Glycolic Acid) Nanoparticles Loaded with Gallic Acid Induce Glioblastoma Cell Death by Reactive-Oxygen-Species-Induced Stress

Ramalho, M. J., Alves, B., Andrade, S., Lima, J. P., Loureiro, J. A., & Pereira, M. D. C. (2024) · Polymers · doi:10.3390/polym16152161 · Cited by 17 · see citing works

Recent progress on nanotechnologies for enhancing blood‐brain barrier permeability

Liu, Q., Chen, Z., Guiseppi‐Elie, A., Meng, F., & Luo, L. (2025) · Smart Molecules · doi:10.1002/smo.20240052 · Cited by 17 · see citing works

Surface-functionalized nanoparticles for targeted drug delivery across the blood-brain barrier: advances and challenges in neurodegenerative disease therapy

Pramoda, G., Verma, R. K., Kesharwani, P., & Shukla, R. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.127938 · Cited by 15 · see citing works

Emerging Perspectives on Prime Editor Delivery to the Brain

BenDavid, E., Ramezanian, S., Lu, Y., Rousseau, J., Schroeder, A., Lavertu, M., & Tremblay, J. P. (2024) · Pharmaceuticals · doi:10.3390/ph17060763 · Cited by 15 · see citing works

Overcoming the blood-brain barrier: targeted delivery strategies for gliomas

Du, X., Chen, C., Zeng, Y., & Lin, Z. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1705234 · Cited by 15 · see citing works

Advancing CNS Therapeutics: Enhancing Neurological Disorders with Nanoparticle-Based Gene and Enzyme Replacement Therapies

Liu, S., Li, H., Xi, S., Zhang, Y., & Sun, T. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s457393 · Cited by 15 · see citing works

“Baihui” ( DU20 )‐penetrating “Qubin” ( GB7 ) acupuncture on blood–brain barrier integrity in rat intracerebral hemorrhage models via the RhoA / ROCK II / MLC 2 signaling pathway

Zhang, C., Zheng, J., Yu, X., Kuang, B., Dai, X., Zheng, L., Yu, W., Teng, W., Cao, H., Li, M., et al. (2024) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12374 · Cited by 14 · see citing works

Folic Acid-Conjugated Brush Polymers Show Enhanced Blood–Brain Barrier Crossing in Static and Dynamic In Vitro Models Toward Brain Cancer Targeting Therapy

Mazrad, Z. A. I., Refaat, A., Morrow, J. P., Voelcker, N. H., Nicolazzo, J. A., Leiske, M. N., & Kempe, K. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01650 · Cited by 14 · see citing works

Innovative strategies for overcoming blood-brain barrier challenges in Alzheimer’s disease: A focus on green-synthesized metallic nanoparticles

Nagori, K., Nakhate, K. T., Yadav, D. K., Thakur, A., Ajazuddin, M., & Pradhan, M. (2024) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2024.113604 · Cited by 14 · see citing works

Neurovascular unit in ischemic stroke in older adults: a narrative review

Wang, C., Yang, Y., Xiong, T., & Li, S. (2025) · Aging advances. · doi:10.4103/agingadv.agingadv-d-24-00031 · Cited by 14 · see citing works

The battle of lipid-based nanocarriers against blood-brain barrier: a critical review

Abla, K. K., & Mehanna, M. M. (2023) · Journal of drug targeting · doi:10.1080/1061186x.2023.2247583 · Cited by 15 · see citing works

Ursolic acid nanoparticles for glioblastoma therapy

Li, Y., Zhao, L., Zhao, Q., Zhou, Y., Zhou, L., Song, P., Liu, B., Chen, Q., & Deng, G. (2023) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2023.102684 · Cited by 13 · see citing works

Polymeric nanotherapeutics: An emerging therapeutic approach for the management of neurodegenerative disorders

Chakraborty, P., Bhattacharyya, C., Sahu, R., Dua, T. K., Kandimalla, R. J. L., & Dewanjee, S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105267 · Cited by 11 · see citing works

Nanotechnology in Parkinson’s Disease: overcoming drug delivery challenges and enhancing therapeutic outcomes

Ali, I., Adil, M., Imran, M., Qureshi, S. A., Qureshi, S., Hasan, N., & Ahmad, F. J. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01799-8 · Cited by 11 · see citing works

Combined Strategies for Nanodrugs Noninvasively Overcoming the Blood–Brain Barrier and Actively Targeting Glioma Lesions

Liu, Y., Wu, H., & Liang, G. (2025) · Biomaterials Research · doi:10.34133/bmr.0133 · Cited by 10 · see citing works

Current Landscape and Future Prospects of Radiation Sensitizers for Malignant Brain Tumors: A Systematic Review

Beg, U., Snyder, B., Madhani, S. I., Hamidi, N., Padmanaban, V., Tuanquin, L. C., Kruser, T. J., Connor, J. R., & Mansouri, A. (2021) · World Neurosurgery · doi:10.1016/j.wneu.2021.04.134 · Cited by 10 · see citing works

Targeted Polymersomes Enable Enhanced Delivery to Peripheral Nerves Post-Injury

Trumbull, K., Fetten, S., Arnold, N., Marahrens, V., Montgomery, D., Myers, O., Twiss, J. L., & Larsen, J. (2025) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5c00072 · Cited by 9 · see citing works

Harnessing immunotherapy: cancer vaccines as novel therapeutic strategies for brain tumor

Kiel, K., Piranlioglu, R., Godlewski, J. A., & Bronisz, A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1588081 · Cited by 8 · see citing works

Development of nanomedicines for the treatment of Alzheimer’s disease: Raison d’être, strategies, challenges and regulatory aspects

Mazahir, F., Alam, M. I., & Yadav, A. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102318 · Cited by 9 · see citing works

Optimized lipopolymers with curcumin to enhance AZD5582 and GDC0152 activity and downregulate inhibitors of apoptosis proteins in glioblastoma multiforme

Kuo, Y., Yen, M.-H., De, S., Rajesh, R., & Tai, C.-K. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213639 · Cited by 8 · see citing works

Plant-based flavonoids and their nanoparticles: Latest arsenal against Alzheimer’s disease

Kumbhar, P., Kolekar, K. A., Vishwas, S., Kamble, V., Bashir, B., Patil, K. S., Bhagwat, D. A., Gupta, G., Prasher, P., Singh, M., et al. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01906-9 · Cited by 6 · see citing works

A comprehensive review on lipid-based nanoparticles via nose to brain targeting as a novel approach

Hameed, H., Faheem, S., Younas, K., Jamshaid, M., Ereej, N., Hameed, A., Munir, R., & Khokhar, R. (2024) · Journal of Microencapsulation · doi:10.1080/02652048.2024.2404414 · Cited by 7 · see citing works

Discovery of a Novel Dual Targeting Peptide for Human Glioma: From In Silico Simulation to Acting as Targeting Ligand

Aminabad, N. S., Saeedi, Y., Adiban, J., Nemati, M., Shaterabadi, D., Najafi, F., Rahbarghazi‬, R., Talebi, M., & Zarebkohan, A. (2024) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2024.033 · Cited by 5 · see citing works

Advances in solid-lipid nanoparticle chemistry as drug delivery vehicles

Garg, G., Garg, S., Patel, P., Gupta, G. D., & Kurmi, B. D. (2024) · International Journal of Polymeric Materials · doi:10.1080/00914037.2024.2344603 · Cited by 5 · see citing works

Drug delivery systems for neural tissue engineering

Güler, E., Polat, E. B., & Çam, M. E. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90554-1.00012-4 · Cited by 4 · see citing works

Drug Delivery to the Brain Using Endocytic Receptors as Carriers

Talwar, P., Saha, P., Anjana Mohan, A., Divya, S., & Ravanan, P. (2025) · The Receptors · doi:10.1007/978-3-031-81991-9_19 · Cited by 4 · see citing works

The Twofold Role of Osteogenic Small Molecules in Parkinson’s Disease Therapeutics: Crosstalk of Osteogenesis and Neurogenesis

Tavakol, S. (2022) · BioMed Research International · doi:10.1155/2022/3813541 · Cited by 4 · see citing works

A dynamic study of VEGF-A siDOX-EVs trafficking through the in-vitro insert co-culture blood-brain barrier model by digital holographic microscopy

Shamshiripour, P., Rahnama, M., Nikoobakht, M., Hajiahmadi, F., Moradi, A.-R., & Ahmadvand, D. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1292083 · Cited by 3 · see citing works

Identification of Variable Lymphocyte Receptors That Target the Human Blood–Brain Barrier

Katt, M. E., Waters, E. A., Gastfriend, B. D., Herrin, B. R., Cooper, M. D., & Shusta, E. V. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17091179 · Cited by 3 · see citing works

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Chen, C., Chen, X., Gao, Z., Sun, M., Yu, Y., Lv, F., wang, Q., & Zhang, J. (2026) · Advanced Science · doi:10.1002/advs.202521428 · Cited by 3 · see citing works

RNA ‐Based Therapies for Inherited Metabolic Disorders

Reddy, S. V., Gurung, S., Ghosh, R., Mills, P. B., Baruteau, J., & Zhou, H. (2026) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.70150 · Cited by 3 · see citing works

Blood–brain barrier and nanovesicles for brain-targeting drug delivery

Omidi, Y., Omidian, H., Kwon, Y., & Castejon, A. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91865-7.00007-9 · Cited by 3 · see citing works

Ultrasound combined blood‐brain barrier targeting brain delivery of four‐in‐one molecular aggregates for the enhancement of anesthetic efficacy and toxicity reduction via propofol‐etomidate synergistically inhibition GABA receptor

Zhang, S., Wang, Y., Zhu, M., Liu, B., Zhao, W., Zhang, S., Xia, J., Shi, L., Tang, P., Wang, F., et al. (2024) · Aggregate · doi:10.1002/agt2.573 · Cited by 3 · see citing works

Exploring New Structures of Kinase Inhibitors and Multitarget Strategies in Alzheimer's Disease Treatment

Tripathi, S., Sharma, Y., & Kumar, D. (2024) · Protein and Peptide Letters · doi:10.2174/0109298665348075241121071614 · Cited by 3 · see citing works

Molecular dynamics simulation of the brain-isolated single-domain antibody/nanobody from camels through in vivo phage display screening

Hasannejad-Asl, B., Hashemzadeh, H., Pooresmaeil, F., Dabiri, M., Pooresmaeil, M.-R., Ahmadvand, D., & Hosseini, A. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1414119 · Cited by 3 · see citing works

Carbohydrate biopolymer-based nanocomposites as strategic modality in addressing brain cancer

Satapathy, B. S., Mishra, A., & Nayak, A. K. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146482 · Cited by 2 · see citing works

Carboxymethyl chitosan for neurological drug delivery: Current trends and future prospects

Patel, R., Mevada, S., Shukla, S., Bhattacharya, S., Alsaidan, O. A., & Prajapati, B. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150488 · Cited by 2 · see citing works

Molecular determinants of K36 binding in SARS-CoV-2 main protease revealed by MD simulations and alanine mutagenesis

AbouYoussef, M. L., El‐Kelany, K. E., Gaber, S. A. A., & Aboelnga, M. M. (2026) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2026.2632174 · Cited by 2 · see citing works

In situ nasal gel loaded with Lactoferrin-Coated Brexpiprazole nanostructured lipid carriers for Schizophrenia: Cross-Species validation in Ketamine-Induced rat and zebrafish models

Parmar, J., Patel, N., Patel, A., Desai, N., & Shah, P. (2026) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2026.115131 · Cited by 2 · see citing works

Nanomaterials for Diagnosis and Treatment of Common Neurological Disorders

Kaur, G., Chirayimmel, A. J., Rana, P., Sharma, S., Bose, J. C., Rath, S. K., & Dwibedi, V. (2024) · Smart nanomaterials technology · doi:10.1007/978-981-97-0308-1_8 · Cited by 2 · see citing works

EXOSOMES AS MEDIATORS OF NEUROINFLAMMATION IN PARKINSON'S DISEASE: A REVIEW

Sheikh, M., Saiyyad, A., & Jirvankar, P. (2025) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2025v17i3.53756 · Cited by 2 · see citing works

Surface Active Ligands for Enhanced Brain Targeting of Nanoparticles

Prabakaran, A., Vashist, R., Sangave, S. D., & Alexander, A. (2024) · Springer eBooks · doi:10.1007/978-981-97-2859-6_9 · Cited by 2 · see citing works

Optical spectroscopy and nonlinearity of doxepin-loaded copper oxide nanoparticles

Yang, J., Liu, J., Fang, K., Ke, C., Zhang, W., Wang, H., & Tayebee, R. (2023) · Chemical Papers · doi:10.1007/s11696-023-02740-4 · Cited by 1 · see citing works

Nanomaterials as Drug Delivery Vehicles for Therapy of Parkinson's Disease

Chirayimmel, A. J., Kaur, G., Rana, P., Rath, S. K., Mandal, S. K., & Dwibedi, V. (2024) · Smart nanomaterials technology · doi:10.1007/978-981-97-0308-1_13 · Cited by 1 · see citing works

Review of Existing Method for Brain Delivery

Wang, Y., Li, Y., Li, W., & Yang, Y. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2024.19393 · Cited by 1 · see citing works

Formulation of folic acid-decorated β-cyclodextrin-based magnetic nanoparticles hybrid nanotherapeutic for targeted delivery of chlorogenic acid

Pathan, S. J., Bhinge, S. D., Mohite, S. K., Nangare, S., Bhutkar, M. A., Jadhav, N. R., Patil, S., Kumbhar, S. T., & Gurav, S. S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107536 · Cited by 1 · see citing works

Development and characterization of multifunctional dendrimeric nanoconjugates for delivery of rutin: in vitro characterization for potential neuroprotective application

Sonwani, A., Pathak, A., & Jain, K. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2576463 · Cited by 1 · see citing works

Liposomes as a Potential Carrier for Brain Delivery

Thakur, A. S., Vishwas, S., Badwaik, H., Paul, S. D., Sakure, K., & Nakhate, K. T. (2024) · Springer eBooks · doi:10.1007/978-981-97-2859-6_6 · Cited by 1 · see citing works

Nano-Enhanced Antibiotic Delivery for Skin Cancer Treatment: A Breakthrough in Nanomedicine

Alanazi, F., Abdulrahman, S., Asiri, O. A., Alasmry, M., Alshahrani, N. A., Aseri, S., Abdualrahim, M., Almuzaini, R., Alotaibi, R., Babalghaith, R., et al. (2025) · Pharmacy Practice · doi:10.18549/pharmpract.2025.2.3117 · Cited by 1 · see citing works

Ligand appended theranostic nanocarriers for targeted blood–brain barrier

Rawat, S., Pal, A., Choubey, R., Bajpai, J., & Bajpai, A. K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89953-6.00015-5

Targeted Therapy for Neurological Disorders Using Nanomaterial-Based Drug Delivery Vehicle

Sharma, M., Gupta, T., Gupta, N., Rawat, R., Badoniya, N., Pandey, E., & Sharma, S. (2024) · Smart nanomaterials technology · doi:10.1007/978-981-97-0308-1_7

Minimally invasive nasal depot (MIND) technique for direct BDNF AntagoNAT delivery to the brain

D'Sa, M. M., Patel, N., Savla, H. M., & Shaikh, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23841-3.00012-1

The blood–brain barrier: Gatekeeper and obstacle in neurodegenerative disorders

Bassiony, M., Ibrahem, M. A., Youssef, D. G., Elbadry, A. M. M., & Alaboudi, O. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00002-6

Nanoparticle-mediated drug delivery for neurodegenerative diseases

Parhi, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28822-7.00013-1

Thin film forming method

(2004) · Metal Finishing · doi:10.1016/s0026-0576(04)84716-0

Receptor-mediated transportation through BBB

Zhang, Z., & Zhan, C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814001-7.00005-6 · Cited by 14 · see citing works

Drug Delivery to the Brain Using Endocytic Receptors as Carriers

Talwar, P., Saha, P., Anjana Mohan, A., Divya, S., & Ravanan, P. (2025) · The Receptors · doi:10.1007/978-3-031-81991-9_19 · Cited by 4 · see citing works

Differential receptor-mediated drug targeting to the diseased brain

Rip, J., Schenk, G., & de Boer, A. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240902806383 · Cited by 98 · see citing works

Receptor-mediated delivery of drugs across the blood-brain barrier

Pieter, G. (2010) · Frontiers in Pharmacology · doi:10.3389/conf.fphar.2010.02.00025 · Cited by 14 · see citing works