Brainstem catecholamine neurons are target sites for sex steroid hormones.
Abstract
Sex steroid hormones and catecholamines have physiological interactions in the brain. By the combined use of autoradiography and fluorescence histochemistry, steroid hormone target sites and catecholamine neurons were visualized simultaneously in the same tissue preparation. By this dual localization method, [3 H]estradiol and [3 H]dihydrotestosterone target sites were identified in nuclei of many catecholamine cell bodies in the brainstem, and catecholamine nerve terminals were observed near certain steroid hormone target neurons. These results suggest close anatomical interrelations between steroid hormone sites of action and catecholamine sites of production and action in the brain.
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Estrogen and progesterone receptors occur in nonreproductive tissues that regulate fluid, including the hypothalamus, cardiovascular system, and kidney tubules.
“Receptors for estrogens and progesterone are found in nonreproductive tissue involved in fluid regulation, such as the hypothalamus (10,21), the cardiovascular system (6,19), and the kidney tubules (6).”
From Sex Hormone Effects on Body Fluid Regulation (2008) · cites this paper as [10]
Estrogen receptors are present in hypothalamic nuclei of animals that produce AVP, and studies have found sex differences in AVP neuron activity and size in these nuclei.
“Estrogen receptors are present in the hypothalamic nuclei of animals known to produce AVP (10,21), and a number of studies have demonstrated sex differences in the AVP neuron activity and size in these nuclei (12).”
From Sex Hormone Effects on Body Fluid Regulation (2008) · cites this paper as [10]
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References 33 · Cited by 240
- Authors
- Heritage, A. S., Stumpf, W. E., Sar, M., & Grant, L. D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Science
- Published
- 1980-03-21
- Volume
- 207
- Issue
- 4437
- Pages
- 1377-1379
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977595194
- Cited by
- 240
- References
- 33
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- sex hormones, catecholamines, brainstem, estradiol, dihydrotestosterone, catecholaminergic neurons, dual localization
- MeSH terms
- Adrenalectomy, Animals, Brain, Castration, Catecholamines, Diencephalon, Estradiol, Female, Male, Mesencephalon, Microscopy, Fluorescence, Dihydrotestosterone, Rats
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