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Tritiated Imipramine Binding Sites Are Decreased in Platelets of Untreated Depressed Patients
Abstract
The high-affinity binding of tritiated imipramine to platelet membranes was compared in samples from 16 untreated depressed women and 21 age-matched controls of the same sex. The maximal binding in the depressed group was significantly lower than that of the controls, although the affinity constants were similar. These results suggest that binding of tritiated imipramine in human platelets may represent a biochemical index of depression, possibly reflecting similar changes in the brain.
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Citations
Cited by
The Relationship of Depression to Cardiovascular Disease: Epidemiology, Biology, and Treatment
Musselman, D. L., Evans, D. L., & Nemeroff, C. B. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.580 · Cited by 1,532
Malison, R. T., Price, L. H., Berman, R., van Dyck, C. H., Pelton, G. H., Carpenter, L., Sanacora, G., Owens, M. J., Nemeroff, C. B., Rajeevan, N., et al. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00272-8 · Cited by 496
Holmes, A., Li, Q., Murphy, D. L., Gold, E., & Crawley, J. N. (2003) · Genes, Brain and Behavior · doi:10.1046/j.1601-1848.2003.00050.x · Cited by 313
Preisig, M., Bellivier, F., Fenton, B. T., Baud, P., Berney, A., Courtet, P., Hardy, P., Golaz, J., Leboyer, M., Mallet, J., et al. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.6.948 · Cited by 137
Serotonergic gene expression and depression: implications for developing novel antidepressants
Lesch, K. P. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00351-7 · Cited by 93
Metadata
- Authors
- Briley, M. S., Langer, S. Z., Raisman, R., Sechter, D., & Zarifian, E.
- Venue
- Science
- Published
- 1980-07-11
- Volume
- 209
- Issue
- 4453
- Pages
- 303-305
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010928495
- Cited by
- 438
- References
- 0
- FWCI
- 21.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Tritiated Imipramine Binding Sites Are Decreased in Platelets of Untreated Depressed Patients. https://app.cochat.ai/papers/10.1126/science.7384806
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- Briley, M. S., Langer, S. Z., Raisman, R., Sechter, D., & Zarifian, E. (1980). Tritiated Imipramine Binding Sites Are Decreased in Platelets of Untreated Depressed Patients. Science. https://doi.org/10.1126/science.7384806
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
