Association Between Bipolar Disorder and Monoamine Oxidase A Gene Polymorphisms: Results of a Multicenter Study
Abstract
OBJECTIVE: Although genetic factors have been implicated in the etiology of bipolar disorder, no specific gene has been conclusively identified. Given the link between abnormalities in serotonergic neurotransmission and bipolar disorder, a candidate gene association approach was applied to study the involvement of the monoamine oxidase A (MAOA) gene, which codes for a catabolic enzyme of serotonin, in the susceptibility to bipolar disorder. METHOD: In France and Switzerland, 272 patients with bipolar disorder and 122 healthy subjects were typed for three polymorphic markers of the MAOA gene: the MAOA-CA repeat, the MAOA restriction fragment length polymorphism (RFLP), and a repeat directly adjacent to the variable number of tandem repeats (VNTR) locus. RESULTS: A significant difference in the distribution of the alleles for the MAOA-CA repeat was observed between the female bipolar patients and comparison group. CONCLUSIONS: The results obtained in the French and Swiss population confirm findings from two studies conducted in the United Kingdom.
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Direct implications were demonstrated for the monoamine oxidase A, 5-hydroxytryptamine transporter, and catechol-O-methyltransferase genes in BD.
“In this way, direct implications were demonstrated for the monoamine oxidase A, 5-hydroxytryptamine transporter, and catechol-O-methyltransferase genes [217–220].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [218]
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- Authors
- Preisig, M., Bellivier, F., Fenton, B. T., Baud, P., Berney, A., Courtet, P., Hardy, P., Golaz, J., Leboyer, M., Mallet, J., Matthey, M.-L., Mouthon, D., Neidhart, E., Nosten-Bertrand, M., Stadelmann-Dubuis, E., Guimon, J., Ferrero, F., Buresi, C., & Malafosse, A.
- Affiliations
- University of Lausanne (CH)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2000-06-01
- Volume
- 157
- Issue
- 6
- Pages
- 948-955
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2116710493
- Cited by
- 137
- References
- 39
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 8
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- bipolar disorder, monoamine oxidase A, restriction fragment length polymorphism, variable number tandem repeats, serotonergic neurotransmission, genetic susceptibility, candidate gene association, sex differences
- MeSH terms
- Adult, Alleles, Bipolar Disorder, Female, Genetic Markers, Genotype, Humans, Male, Middle Aged, Monoamine Oxidase, Polymorphism, Genetic, Psychiatric Status Rating Scales, Polymorphism, Restriction Fragment Length, Sex Factors, Polymerase Chain Reaction, Tandem Repeat Sequences
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