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Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in Vitro
Abstract
Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.
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Cited by
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Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Williams, J. T., Christie, M. J., & Manzoni, O. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.299 · Cited by 848
The Physiological Role of Adenosine In The Central Nervous System
Dunwiddie, T. V. (1985) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)60556-5 · Cited by 623
The opiomelanotropinergic neuronal and endocrine systems
O'Donohue, T. L., & Dorsa, D. M. (1982) · Peptides · doi:10.1016/0196-9781(82)90098-5 · Cited by 536
Aghajanian, G. K., & VanderMaelen, C. P. (1982) · Science · doi:10.1126/science.6278591 · Cited by 431
Metadata
- Authors
- Pepper, C. M., & Henderson, G.
- Venue
- Science
- Published
- 1980-07-18
- Volume
- 209
- Issue
- 4454
- Pages
- 394-396
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971474470
- Cited by
- 226
- References
- 0
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pepper, C. M., & Henderson, G. (1980). Opiates and Opioid Peptides Hyperpolarize Locus Coeruleus Neurons in Vitro. Science. https://doi.org/10.1126/science.7384811
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
