The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
α 2 -Adrenoceptor-Mediated Hyperpolarization of Locus Coeruleus Neurons: Intracellular Studies in Vivo
Abstract
Intracellular recordings in vivo from noradrenergic neurons of the rat locus coeruleus showed that membrane potential was hyperpolarized by the administration of clonidine (an α 2 -adrenoceptor agonist) or after a burst of spikes evoked by intracellular pulses; both types of hyperpolarization were associated with a decrease in membrane input resistance, and both could be blocked by the α 2 -adrenoceptor antagonist piperoxane. These results suggest that a hyperpolarization of membrane potential mediated by an α 2 -adrenoceptor underlies both clonidine- and activation-induced inhibition of locus coeruleus cell firing.
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Cites
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Regulation of noradrenaline release by presynaptic receptor systems
Starke, K. (1977) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0050157 · Cited by 1,469
Presynaptic regulation of catecholamine release
Langer, S. Z. (1974) · Biochemical Pharmacology · doi:10.1016/0006-2952(74)90187-7 · Cited by 1,142
Svensson, T. H., Bunney, B. S., & Aghajanian, G. K. (1975) · Brain Research · doi:10.1016/0006-8993(75)90276-0 · Cited by 1,009
Self-citationFoote, S. L., Aston-Jones, G., & Bloom, F. E. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.3033 · Cited by 857
AGHAJANIAN, G. K. (1978) · Nature · doi:10.1038/276186a0 · Cited by 802
Self-citationA functional basis for classification of α-adrenergic receptors
Berthelsen, S., & Pettinger, W. A. (1977) · Life Sciences · doi:10.1016/0024-3205(77)90066-2 · Cited by 796
Catecholamine receptors on locus coeruleus neurons: Pharmacological characterization
Cedarbaum, J. M., & Aghajanian, G. K. (1977) · European Journal of Pharmacology · doi:10.1016/0014-2999(77)90312-0 · Cited by 712
Self-citationClonidine blocks acute opiate-withdrawal symptoms
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Cedarbaum, J. M., & Aghajanian, G. K. (1976) · Brain Research · doi:10.1016/0006-8993(76)90297-3 · Cited by 634
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Charmandari, E., Tsigos, C., & Chrousos, G. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.040403.120816 · Cited by 1,799
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Shalev, U., Grimm, J. W., & Shaham, Y. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.1 · Cited by 880
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STRATAKIS, C. A., & CHROUSOS, G. P. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44666.x · Cited by 533
Samuels, E., & Szabadi, E. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777193 · Cited by 454
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Metadata
- Authors
- Aghajanian, G. K., & VanderMaelen, C. P.
- Venue
- Science
- Published
- 1982-03-12
- Volume
- 215
- Issue
- 4538
- Pages
- 1394-1396
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985525186
- Cited by
- 431
- References
- 23
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Aghajanian, G. K., & VanderMaelen, C. P. (1982). α 2 -Adrenoceptor-Mediated Hyperpolarization of Locus Coeruleus Neurons: Intracellular Studies in Vivo. Science. https://doi.org/10.1126/science.6278591
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
